The essential oil of Valeriana officinalis L. s.l.

Hazelhoff, B.; Smith, D.; Malingré, Th. M.; Hendriks, H.

doi:10.1007/bf02293248

Cited by 12 publications

(13 citation statements)

References 7 publications

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“…The screening method used is an elaboration of the test of CAMPBELL and RICHTER [11]. Several symptoms mentioned by hwm [12] increasing amounts of ether [10]. Purification of the oxygen fractions containing valerenal and valeranone took place by means of preparative TLC.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Screening of Valerenal and some other Components of Essential Oil of Valeriana officinalis

Hendriks

Bos

et al. 1981

Planta Med

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In order to clarify the pharmacological properties of some constituents of the essential oil of Valeriana officinalis L. s. 1. four pure compounds (valerenal, valerenic acid, valeranone and isoeugenyl-isovalerate), a hydrocarbon fraction, an oxygen fraction and the essential oil itself were submitted to a screening test. This test is an elaboration of the screening test of CAMPBELL and RICHTER [11] to which several symptoms mentioned by IRWIN [12] and some other features have been added. From the results of this so-called Syndrome test valerenal and valerenic acid, which show some structural correspondence with the valepotriates, are pharmacologically active at the lowest dose levels. Together with valeranone, both compounds are likely to play a significant role in the depressive action of the essential oil whereas the activity of isoeu-genyl-isovalerate is of relatively minor importance.

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Section: Introductionmentioning

confidence: 99%

Pharmacological Screening of Valerenal and some other Components of Essential Oil of Valeriana officinalis

Hendriks

Bos

et al. 1981

Planta Med

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“…General: 1 H and 13 C NMR spectra were recorded on a Bruker BioSpin GmbH system at 500 and 125 MHz, respectively. Solvents and chemicals used in the experiments were purchased from either Sigma-Aldrich (Taufkirchen, Germany) or Merck (Darmstadt, Germany).…”

Section: Methodsmentioning

confidence: 99%

Characterization of Szovitsia callicarpa Volatile Constituents Obtained by Micro- and Hydrodistillation

Demırcı

Küçükboyacı

Adıgüzel

et al. 2010

Natural Product Communications

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The volatile constituents of Szovitsia callicarpa Fisch. & C. A. Mey. were obtained from the fruits by microdistillation, due to the limited plant material availability. Initial GC-MS analyses of the obtained material showed an unidentified major constituent with a molecular ion peak at M+ 280. After hydrodistillation of the plant material, the resulting essential oil was also analyzed by GC and GC-MS, simultaneously. In total, twenty-two compounds, representing 98.6% of the microdistilled sample, were identified, whereas seventeen components were detected in the hydrodistilled oil, representing 98.5% of the total. The GC-MS analyses showed that the samples contained an unidentified major constituent, which was further purified from the hydrodistilled essential oil by micro-column chromatography. The structure was elucidated as α-kessyl acetate using 1H- and 13C-NMR spectroscopic and mass spectroscopic techniques. Other major constituents in the analytes were determined as longipinene, longicyclene and kessane. In addition, both samples, as well as the major compound α-kessyl acetate, were tested at 1 mg/mL concentration against the pathogen Candida tropicalis and for its free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH•) by TLC-bioauthographic techniques. Both preliminary assays at the tested concentration showed no activity.

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“…Valerian is known for its pharmacological properties, including nxiolytic, antidepressant, antispasmodic, sedative, and anti-HIV activities. [9][10][11][12][13] V. officinalis is still an object of research aimed at establishing the chemical and pharmacological basis of the activity demonstrated in previous studies. 14 Our previous studies on the chemical constituents of the roots of V. officinalis have led to the isolation of several iridoids and one novel mononorsesquitepenoid.…”

Section: Introductionmentioning

confidence: 99%