The essential role of lipids in Alzheimer's disease

The Effects of Hempseed Meal Intake and Linoleic Acid on Drosophila Models of Neurodegenerative Diseases and Hypercholesterolemia

“…HSM intake ameliorated the eye degeneration induced by Aβ42 As hempseed evidences strong antioxidant activity and PUFAs have been associated with a variety of neurodegenerative diseases including AD (Florent-Béchard et al, 2009) The files were reared in CTL media with linoleic acid, linolenic acid, campesterol, or γ-linolenic acid. All fly strains were maintained at 29°C.…”

“…In particular, PUFAs have been implicated in a variety of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) (Das and Vaddadi, 2004;Delattre et al, 2010;Florent-Béchard et al, 2009). In the various experimental models and the brains of human neurodegenerative disease patients, membrane loss of PUFAs was assessed, which has been recognized as a consequence of increased lipid peroxidation induced by elevated reactive oxygen species in these diseases (Das and Vaddadi, 2004;Youdim et al, 2000).…”

“…In the various experimental models and the brains of human neurodegenerative disease patients, membrane loss of PUFAs was assessed, which has been recognized as a consequence of increased lipid peroxidation induced by elevated reactive oxygen species in these diseases (Das and Vaddadi, 2004;Youdim et al, 2000). Accordingly, the moderate consumption of fish, a rich source of n-3 PUFAs, or treatment with PUFAs have all been reported to exert a beneficial effect on cognitive functions via a variety of molecular mechanisms and kinetic functions in human and animal models involving dyskinesia (Das and Vaddadi, 2004;Florent-Béchard et al, 2009). Moreover, docosahexaenoic acid (DHA), a major PUFA found in the brain, has been determined to reduce levels of Aβ in AD cellular models (Florent-Béchard et al, 2009) and to stimulate doparminergic turnover in a rat PD model (Delattre et al, 2010).…”

“…Accordingly, the moderate consumption of fish, a rich source of n-3 PUFAs, or treatment with PUFAs have all been reported to exert a beneficial effect on cognitive functions via a variety of molecular mechanisms and kinetic functions in human and animal models involving dyskinesia (Das and Vaddadi, 2004;Florent-Béchard et al, 2009). Moreover, docosahexaenoic acid (DHA), a major PUFA found in the brain, has been determined to reduce levels of Aβ in AD cellular models (Florent-Béchard et al, 2009) and to stimulate doparminergic turnover in a rat PD model (Delattre et al, 2010). Additionally, both PUFAs and phytosterols have been previously implicated in the prevention of cardiovascular diseases, owing to their ability to lower total cholesterol and low density lipoprotein-cholesterol levels in serum (Harris, 2008;Malini and Vanithakumari, 1990;Miettinen and Gylling, 2004;Patch et al, 2006).…”

“…Additionally, both PUFAs and phytosterols have been previously implicated in the prevention of cardiovascular diseases, owing to their ability to lower total cholesterol and low density lipoprotein-cholesterol levels in serum (Harris, 2008;Malini and Vanithakumari, 1990;Miettinen and Gylling, 2004;Patch et al, 2006). Although a great deal of evidence has been collected to suggest that PUFAs have beneficial effects on brain functions and the regulation of cholesterol, some other studies have raised questions regarding their effects (Florent et al, 2006;Florent-Béchard et al, 2009;Lee et al, 2009); currently, the molecular mechanisms underlying the activities of PUFAs remain to be clearly elucidated.…”