The establishment of the hemangioma model in nude mouse

Infantile Hemangioma

“…Although lesion growth in this model is modest, this is clearly a step in the right direction. Second, Peng et al 69 implanted freshly resected hemangioma tissue subcutaneously into nude mice and stimulated modest growth with weekly injections of estradiol. Although growth of the tumors in these mice was not shown to exhibit characteristic hemangioma features, such as GLUT1 expression or spontaneous regression, it may be that a combination of the 2 models might be as close a model for infantile hemangioma as one is likely to obtain in mice.…”

A Potential Role for Notch Signaling in the Pathogenesis and Regulation of Hemangiomas

“…39 However, these rely on using excised specimens and are involuted in a few months’ time, so the window of time for studies to be performed is limited because the implanted human hemangiomas became fibrotic. Other variations include the injection of estrogen into the mice to delay involution, 40 yet the role and contribution of estrogen to hemangiomas is poorly understood. 41,42 The most promising hemangioma has been reported from the laboratory of Dr Joyce Bischoff.…”

Infantile Hemangiomas: A Disease Model in the Study of Vascular Development, Aberrant Vasculogenesis and Angiogenesis

“…The authors of this paper claimed that this was a model for IH; however, these tumors did not involute. Another xenograft model of infantile hemangioma onto nude mice did recapitulate the involuting phase, but is not an ideal laboratory model in that it has not been demonstrated that these cells can be passaged through mice and therefore requires fresh human sample tissue for each experiment (Peng et al, 2005;Tang et al, 2007). Furthermore, neither of these models recapitulate the proliferative phase of IH, and the authors of these reports did not report evidence of GLUT1 positivity.…”