The estimated prevalence of osteoporosis in Bahrain: a multi-centered-based study

Hassan, Adla Bakri; Tayem, Yasin I.; Sadat-Ali, Mir; Almarabheh, Amer J.; Alawadhi, Abdulhameed; Butt, Ahsan J.; Jahrami, Haitham; Saleh, Jamal; Matar, Mai E.; Shaikh, Mansoor; Hasan, Salman k.; Karashi, Ali R.

doi:10.1186/s12891-023-07145-8

Cited by 5 publications

References 34 publications

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Nonlinear relationship between cardiometabolic index and bone mineral density in U.S. adults: the mediating role of percent body fat

Liu,

Dong,

Zhou

et al. 2024

Sci Rep

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Background: Both lipid metabolism and obesity are crucial factors in osteoporosis, influencing the relevance of the cardiometabolic index (CMI), a new body fat index incorporating obesity and lipid metrics. Our study aims to explore the relationship between CMI and lumbar spine bone mineral density (BMD) and the mediating role of body fat percentage. Methods: Utilizing the National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2018, we conducted a cross-sectional analysis. We employed multiple linear regression models, subgroup analyses, generalized additive models (GAM), smooth curve fitting, and mediation analysis to evaluate the linear and nonlinear relationships between CMI and lumbar spine BMD. Results: The study involved 5,124 participants with an average lumbar spine BMD of 1.03 ± 0.15 g/cm 2 . We identified a negative correlation between CMI and lumbar spine BMD (β = -0.015; 95% CI: -0.023, -0.008). Nonlinear associations were evident, with inflection points at CMI values of 1.12 and 2.86. Subgroup analyses showed consistent negative correlations across all categories without significant differences (p for interaction > 0.05). Moreover, body fat percentage negatively correlated with BMD (β = -0.005; 95% CI: -0.006, -0.004) and mediated 9.41% of the relationship between CMI and BMD. Conclusion: Increased CMI levels are associated with lower lumbar spine BMD, with body fat percentage significantly mediating this relationship. This underscores the importance of managing body composition in the context of bone health, highlighting CMI’s potential utility in osteoporosis risk assessment.

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Nonlinear relationship between cardiometabolic index and bone mineral density in U.S. adults: the mediating role of percent body fat

Liu,

Dong,

Zhou

et al. 2024

Sci Rep

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Prevalence and Risk Factors of Osteoporosis: a Cross-Sectional Study in a Tertiary Center

Ozmen,

Kurt,

Timur

et al. 2024

Preprint

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Background: Osteoporosis is a common disease of the skeletal system that increases the risk of fracture. The prevalence of osteoporosis has been increasing as the aging population increases, affecting more than 200 million people worldwide. This study aimed to shed light on the clinical impact of osteoporosis on women’s health and quality of life by evaluating the prevalence and risk factors for this disease among postmenopausal women, using a 10-year dataset from a tertiary center. Materials and Methods: This retrospective cohort study was conducted at Dokuz Eylul University, Department of Obstetrics and Gynecology, between 2010 and 2022. A total of 3289 postmenopausal women aged 50-60 years who were undergoing routine gynecological checkups were included in the study. Patients with a prior diagnosis, a history of medical conditions or who were taking medications affecting bone mineral density were excluded. Data on demographics, smoking status, diabetes status, body-mass index (BMI), parity, and fracture history were collected. Bone mineral density sores were classified as normal, osteopenia, or osteoporosis. Results: The prevalence of osteoporosis was 10.4%. The median age of the patients was 56.0 years. Smoking, diabetes, and a history of bone fractures were found to significantly increase the risk of osteoporosis. BMI was found to have a protective effect against osteoporosis. According to multivariate analysis, the risk of osteoporosis increased by 2.46 times in patients who smoke, 3.78 times in patients with diabetes, and 6.23 times in patients with a history of fractures. Conclusions:Awareness of modifiable risk factors such as smoking is crucial for preventing osteoporosis-related complications. Diabetes, even when it is not complicated, increases the risk of osteoporosis. Physical exercise, calcium, and vitamin D intake are important, especially during young adulthood, as they are the primary contributors to peak bone mass. Because ne fractures are more common in patients with osteopenia, early diagnosis and routine screening can mitigate future complications.

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Alendronate for Effective Treatment of Male Osteoporosis: An Insight

Al Lawati,

Al Busaidi,

Al Rawahi

et al. 2025

CPD

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Osteoporosis is a major global health problem. The increase in the incidence of osteoporosis in the elderly poses a challenge to treat and also results in an economic burden for the nation. Osteoporosis has been given more importance in females, and there is an urgent need to address this disease in males. Various drugs, such as nitrogen-containing bisphosphonates, RANK ligand inhibitors, parathormones, and alendronate, have been used for effective treatment of osteoporosis. Alendronate (alendronic acid), a nitrogen-containing bisphosphonate that inhibits bone resorption by osteoclasts, was synthesized during the 1970s. In the present review, we discuss the pharmacokinetics, mechanism of action, adverse effects, contraindications, and toxicity monitoring of alendronate. The drug may be effectively used for the treatment of male osteoporosis in order to increase bone mineral density and prevent fractures.

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The estimated prevalence of osteoporosis in Bahrain: a multi-centered-based study

Cited by 5 publications

References 34 publications

Nonlinear relationship between cardiometabolic index and bone mineral density in U.S. adults: the mediating role of percent body fat

Nonlinear relationship between cardiometabolic index and bone mineral density in U.S. adults: the mediating role of percent body fat

Prevalence and Risk Factors of Osteoporosis: a Cross-Sectional Study in a Tertiary Center

Alendronate for Effective Treatment of Male Osteoporosis: An Insight

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