The Estrogenic Substances

Doisy, Edward A.

doi:10.1001/jama.1941.62820060004011

Cited by 12 publications

(1 citation statement)

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“…Parkes & Bellerby (1926), harking back to Virgil, proposed 'oestrin' explicitly to accommodate the compound's estrusproducing property. Oestrin would eventually morph into estrone, providing the etymological stem for a generation of natural and synthetic estrus-producing steroids that were about to be discovered and synthesized (Doisy 1941).…”

Section: What's In a Name?mentioning

confidence: 99%

On gonads and gadflies: the estrus angle

Hillier

2017

Journal of Endocrinology

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The first sex steroid to be crystallized was the vertebrate ovarian hormone, estrone -a less potent metabolite of 17β-estradiol, which in mammals stimulates the female urge to mate (estrus). The gadfly (Greek oistros) lent its name to the process of estrus, as an insect that bites and torments in classical Greek mythology. With the purification and crystallization of a moult-inducing steroid (ecdysone) from insects, an interesting parallel emerged between mating and moulting in lower mammals and arthropods. Ecdysterone (potent ecdysone metabolite) has anabolic effects in mammalian muscle cells that can be blocked by selective estrogen receptor antagonists. Insects utilize ecdysteroids in similar ways that vertebrates use estrogens, including stimulation of oocyte growth and maturation. Ecdysteroids also modify precopulatory insect mating behaviour, further reinforcing the gonad-gadfly/mate-moult analogy.

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Section: What's In a Name?mentioning

confidence: 99%