2008
DOI: 10.1002/ar.20797
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The Estrous Cycle Modulates Small Leucine‐Rich Proteoglycans Expression in Mouse Uterine Tissues

Abstract: In the pregnant mouse uterus, small leucine-rich proteoglycans (SLRPs) are drastically remodeled within a few hours after fertilization, suggesting that ovarian hormone levels modulate their synthesis and degradation. In this study, we followed by immunoperoxidase approach, the presence of four members of the SLRP family (decorin, lumican, biglycan, and fibromodulin) in the uterine tissues along the estrous cycle of the mouse. All molecules except fibromodulin, which predominates in the myometrium, showed a st… Show more

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Cited by 26 publications
(32 citation statements)
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“…In the human endometrium, estrogen and progesterone receptors are also differently expressed in the basal and functional layers (Coppens et al 1993;Critchley et al 2001). These results reinforce previous studies from our group showing that the mouse endometrium presents a compartmentalization similar to that of the human endometrium (Oliveira et al 1995(Oliveira et al , 1998Zorn et al 1995;Greca et al 1998;Salgado et al 2009aSalgado et al , b, 2011Salgado et al , 2013Favaro et al 2014). While the superficial stroma (functional layer in humans) commits with decidualization, the deep stroma (basal layer) remains undifferentiated and contributes to reconstruct the endometrium after pregnancy (Abrahamsohn 1983; Kleinfeld and O'Shea 1983;Favaro et al 2014;Cao et al 2015).…”
Section: Discussionsupporting
confidence: 92%
“…In the human endometrium, estrogen and progesterone receptors are also differently expressed in the basal and functional layers (Coppens et al 1993;Critchley et al 2001). These results reinforce previous studies from our group showing that the mouse endometrium presents a compartmentalization similar to that of the human endometrium (Oliveira et al 1995(Oliveira et al , 1998Zorn et al 1995;Greca et al 1998;Salgado et al 2009aSalgado et al , b, 2011Salgado et al , 2013Favaro et al 2014). While the superficial stroma (functional layer in humans) commits with decidualization, the deep stroma (basal layer) remains undifferentiated and contributes to reconstruct the endometrium after pregnancy (Abrahamsohn 1983; Kleinfeld and O'Shea 1983;Favaro et al 2014;Cao et al 2015).…”
Section: Discussionsupporting
confidence: 92%
“…The difference, or lack thereof, in dosage and expression of BGN between male and female participants has not been fully explored, and may play a role in the altered risk of ACL injury in female participants. Ovarian hormone levels, particularly oestrogen, modulate the synthesis and degradation of SLRPs such as biglycan and decorin 49 50. Receptor sites for oestrogen and progesterone have been found in the ACL,51 52 and sex hormones are suggested to affect ACL structure and composition 51.…”
Section: Discussionmentioning
confidence: 99%
“…All steps were performed in a humid chamber in order to avoid dehydration of the sections. Antigen retrieval was carried out for all antibodies including the samples where the enzymatic treatment was performed, 10,2628 by immersing the slide in sodium citrate solution (10 mM, pH 6.0) for 15 min at 95°C. Non-specific staining was blocked by incubating the slide with Cas-Block solution (Zymed Laboratories, South San Francisco, CA, USA) for 10 min.…”
Section: Methodsmentioning
confidence: 99%