The ethnobotanical, phytochemical and pharmacological profile of the genus Pinellia

Ji, Xiao Hong; Huang, Bao‐Kang; Wang, Guowei; Zhang, Chunyan

doi:10.1016/j.fitote.2013.12.010

Cited by 63 publications

(37 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pinelliae Rhizoma, the tuber of Pinellia ternata (Thunb.) Breit., named “Banxia” in Chinese, is widely used in traditional medicine for the treatment of various ailments such as cough, vomiting, inflammation, epilepsy, cervical cancer and traumatic injury (Ji, Huang, Wang, & Zhang, ). Modern pharmacological studies have revealed that P. ternata tuber (PT) has multiple activities, including sedative–hypnotic (Wu et al, ), anticarcinogenic (Li et al, ), antiasthmatic (Kim et al, ), antiemetic (Kurata et al, ) and anti‐inflammatory (Lee et al, ) activities.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic analysis of raw Pinelliae Rhizoma and its alum‐processed products via UPLC–MS and their cytotoxicity

Sun

Zhang

Wang

et al. 2018

Biomedical Chromatography

View full text Add to dashboard Cite

Alum-processing is a traditional method to attenuate the toxicity of Pinelliae Rhizoma (tubers of Pinellia ternate, PT). The present study aimed at investigating the chemical and cytotoxic changes during alum processing. Metabolomic profiles of raw and alum-processed PT were studied based on ultra-performance liquid chromatography coupled with Orbitrap mass spectrometry. More than 80 chemicals in positive MS mode and 40 chemicals in negative MS mode, such as organic acids, amino acids, glucosides and nucleosides, were identified after multivariate statistical analysis, including principal component analysis and orthogonal partial least-square discriminant analysis. Almost all of the identified chemical markers were significantly decreased 10-to 100-fold after alum processing. Meanwhile, the correlations between the chemical markers were assimilated to a positive coefficient from disorderly distribution during the processing. Raw PT extracts could inhibit the proliferation of human carcinoma cells (HCT-116, HepG2, and A549) at the rate of 40.5, 24.8 and 31.6% more strongly than processed PT. It was concluded that the alum processing of PT could decrease the number of actively water-soluble principles at the same time as decreasing toxicity. Given the water-insoluble property of toxic calcium oxalate raphides in PT, we suggest that a more scientific processing method should be sought.

show abstract

Section: Introductionmentioning

confidence: 99%

Metabolomic analysis of raw Pinelliae Rhizoma and its alum‐processed products via UPLC–MS and their cytotoxicity

Sun

Zhang

Wang

et al. 2018

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…Many researchers have explored its organ toxicities, and found that PR could cause liver, kidney and heart toxicities. Intragastric administration of the water extract and the acid-water percolating liquid of PR could cause acute renal and liver damage and increase the activity of ALT and AST in mice 32 33 34 . In our experiments, we used the PR powder suspension to treat rats for 14 days, and found that raw PR caused heart damage.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processing

Tan

Tsui

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Pinelliae Rhizoma (PR) is a commonly used Chinese medicinal herb, but it has been frequently reported about its toxicity. According to the traditional Chinese medicine theory, processing can reduce the toxicity of the herbs. Here, we aim to determine if processing reduces the toxicity of raw PR, and to explore the underlying mechanisms of raw PR-induced toxicities and the toxicity-reducing effect of processing. Biochemical and histopathological approaches were used to evaluate the toxicities of raw and processed PR. Rat serum metabolites were analyzed by LC-TOF-MS. Ingenuity pathway analysis of the metabolomics data highlighted the biological pathways and network functions involved in raw PR-induced toxicities and the toxicity-reducing effect of processing, which were verified by molecular approaches. Results showed that raw PR caused cardiotoxicity, and processing reduced the toxicity. Inhibition of mTOR signaling and activation of the TGF-β pathway contributed to raw PR-induced cardiotoxicity, and free radical scavenging might be responsible for the toxicity-reducing effect of processing. Our data shed new light on the mechanisms of raw PR-induced cardiotoxicity and the toxicity-reducing effect of processing. This study provides scientific justifications for the traditional processing theory of PR, and should help in optimizing the processing protocol and clinical combinational application of PR.

show abstract

“…Our previous study has shown that [6]-Gingerol, a major component of ginger, could signi cantly ameliorate the cisplatin-induced pica in rats [8]. Pinellia species also have many biological activities including antiin ammatory, anticancer, insecticidal, antitussive, anticonvulsant and antiemetic activities [9]. The main active components of Pinellia include alkaloids, lectins, fatty acids, cerebrosides, phenylpropanoids, sterols and avonoids [9.…”

Section: Introductionmentioning

confidence: 99%

Effects of Xiao-Ban-Xia-Tang Formula on Cisplatin and 1-phenylbiguanide Hydrochloride Induced Emesis and Gut Microbiota in the Pica Model of Rats

Yang¹,

Feng²,

Chen³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: In this study, the effects of Xiao-Ban-Xia-Tang (XBXT) formula on cisplatin and 1-phenylbiguanide hydrochloride (1-PBG) induced acute and delayed emesis and gut microbiota were studied in the pica model of rats, compared with ondansetron. Methods: Two rat models of cisplatin and 1-PBG induced pica were established, the amount of kaolin intake was observed, and the effects of XBXT and ondansetron on the gut microbiota were further studied by 16S rDNA gene analysis. Results: The results showed that the total intake of kaolin of the rats injected with cisplatin and 1-PBG was significantly increased, and treatment of XBXT and ondansetron could significantly ameliorate the acute and delayed pica induced by cisplatin and 1-PBG. The 16S rDNA gene analysis has shown that the alpha diversity of the gut microbiota of the cisplatin and 1-PBG treated rats was significantly decreased compared with the control group, and ondansetron could further decrease the alpha diversity of the gut microbiota of the rats treated with cisplatin. Ondansetron significantly decreased the relative abundance of Firmicutes and increased the abundance of Bacteroidetes on phylum level in the cisplatin and 1-PBG treated rats, while XBXT only decreased Firmicutes in the cisplatin treated rats. Conclusions: XBXT was as effective as ondansetron in the treatment of acute and delayed pica induced by cisplatin and 1-PBG in rats. Ondansetron was more likely to cause gut microbiota dysbiosis than XBXT. Our study provided new avenues for the roles and mechanisms of XBXT on the prevention and treatment of CINV.

show abstract

The ethnobotanical, phytochemical and pharmacological profile of the genus Pinellia

Cited by 63 publications

References 31 publications

Metabolomic analysis of raw Pinelliae Rhizoma and its alum‐processed products via UPLC–MS and their cytotoxicity

Metabolomic analysis of raw Pinelliae Rhizoma and its alum‐processed products via UPLC–MS and their cytotoxicity

Metabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processing

Effects of Xiao-Ban-Xia-Tang Formula on Cisplatin and 1-phenylbiguanide Hydrochloride Induced Emesis and Gut Microbiota in the Pica Model of Rats

Contact Info

Product

Resources

About