The Ethnobotany and Chemistry of South African Meliaceae: A Review

Oyedeji-Amusa, M.O.; Sadgrove, Nicholas J.; Wyk, Ben‐Erik Van

doi:10.3390/plants10091796

Cited by 16 publications

(9 citation statements)

References 113 publications

(175 reference statements)

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“…The known Brazilian genus Trichilia was a huge potential for the production of new drugs and herbal medicines. Several species of Trichilia have been used in folk medicine in the treatment of diseases such as liver disorders, purgative, antiepileptic, antipyretic, antimalarial, physical and mental tonic, and aphrodisiac and sexual stimulants [ 161 , 162 ]. The Walsura genus is commonly used as folk medicine in Thailand with potent antioxidant activity [ 163 ].…”

Section: Ethnobotany and Medicinal Usesmentioning

confidence: 99%

Sesquiterpenoids from Meliaceae Family and Their Biological Activities

2023

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Sesquiterpenoids, an important class of natural products possessing three isoprene-derived units, are widely distributed across plants and have a variety of biological activities. All sesquiterpenoids are derived from farnesyl pyrophosphate (FPP), a biosynthesis precursor that can form various carbon skeletons. In order to provide a reference for further research and development of these compounds, this review focused on the increasing number of isolated and volatile sesquiterpenoids found to be produced by plants of the Meliaceae family between 1968 and 2023. The related articles were collected from SciFinder, Google Scholar, and PubMed. According to a literature review, several studies were started for more than 55 years on the plant’s stem barks, twigs, leaves, flowers, seeds, and pericarps, where approximately 413 sesquiterpenoid compounds from several groups such as eudesmane, aromadendrane, cadinane, guaiane, bisabolane, furanoeremophilane, humulene, germacrane, and oppositane-type were isolated and identified with some minor products. Additionally, the hypothetical route of sesquiterpenoids biosynthesis from this family was identified, and eudesmane-type was reported to be 27% of the total compounds. The antimicrobial, antidiabetic, antioxidant, antiplasmodial, antiviral, and cytotoxic activities of the isolated compounds and major volatile sesquiterpenoids constituent on essential oil were also evaluated. The result showed the fundamental of using the sesquiterpenoid compounds from the Meliaceae family in traditional medicine and the discovery of new drugs.

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Section: Ethnobotany and Medicinal Usesmentioning

confidence: 99%

Sesquiterpenoids from Meliaceae Family and Their Biological Activities

2023

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“…Traditionally, diferent parts of T. dregeana are used for the treatment of wounds [6][7][8], gonorrhea [9,10], syphilis [11], and warts [6] and as immunity booster [12] by diferent communities. Mainly the leaf of the plant is used to treat wounds even though the ways of preparations and applications are diferent among communities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Wound Healing and Anti‐Inflammatory Activities of 80% Methanol Crude Extract and Solvent Fractions of Trichilia dregeana Sond (Meliaceae) Leaves in Mice

Shewaye

Kahaliw

Belete

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Introduction. The leaves of Trichilia dregeana Sond are traditionally used to treat wounds. Even though there have been in vitro studies and claims supporting wound healing, there are no scientific data on in vivo wound healing and anti-inflammatory activities of the leaves of T. dregeana. Objective. This study aimed to evaluate wound healing and anti-inflammatory activity of 80% methanol crude extract and solvent fractions of T. dregeana in mice. Method. The leaves of T. dregeana were dried, ground, and macerated with 80% methanol three times successively. The crude extract was fractioned by water, ethyl acetate, and hexane separately. The acute dermal and oral toxicity tests were done by applying 2000 mg/kg of 10% (w/w) crude extract ointment (CEO) topically and 2000 mg/kg of crude extract orally, respectively. The wound healing activity of the crude extract was evaluated on excision, incision, and burn wound models while the fractions were evaluated only on excision wound model. The anti-inflammatory activity of the crude extract was evaluated on xylene-induced ear edema and cotton pellet granuloma tests. Result. Both acute dermal and oral toxicity tests were found to be safe after topical application of 2000 mg/kg of 10% (w/w) CEO and oral administration of 2000 mg/kg of crude extract suspension, respectively. Both 5% and 10% (w/w) CEO produced significant ( p < 0.001) wound contraction and period of epithelialization from day 4 onwards as compared to simple ointment (SO) on both excision and burn wounds. The tensile strength was increased significantly ( p < 0.001) for the CEO-treated mice as compared to both untreated and SO groups. The crude extract also showed anti-inflammatory activity at 100, 200, and 400 mg/kg by inhibiting ear edema, exudate, and granuloma formation as compared to the SO group. Conclusion. The increase in wound contraction, reduction in period of epithelialization, and increase in tensile strength support the traditional claims of T. dregeana for wound healing.

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“…Also, M. volkensii is being propagated via vegetative propagation owing to its complexity in germination and regeneration 11 . All Melia species are gaining momentum among researchers not only for their secondary metabolites 12,13 , but also for timber utility. Since researchers are working on different dimensions of the genus Melia, the present work is aimed at exploring how research on the genus has evolved.…”

Section: Introductionmentioning

confidence: 99%

Research trends of Melia in tropical plantation forestry

Sahoo

et al. 2023

Preprint

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The genus Melia is known for its secondary metabolite utility but there are vast differences among its species. One species of this genus, Melia azedarach is reported to be invasive and while another species, M. dubia, has diverse utility with complex germination and regeneration characteristics. Researchers are working on the different aspects of this genus, with an increasing number of scientific publications. We attempted to understand facets of the scientific literature on this genus using the topic modelling and science mapping approach. The literature corpus of the Web of Science database was explored using a single keyword – “Melia” which yielded 1523 publications (1946–2022) and after scrutiny 1263 publications were used in the study. Although nine species were mentioned in the publications, only three species are accepted: M. dubia, M. azedarach, and M. volkensii. This implies taxonomic uncertainty, with potential confusion in assigning scientific findings to particular species. This needs to be sorted out for a better assessment of the economic utility of the genus in many countries. More importantly, our results indicate that the research interests have shifted from the secondary metabolite constituents towards growth, biomass, wood properties, germination, plantation, and green synthesis. The shift in research focus toward wood properties of Melia sp. can impact the wood demand-supply at a global scale owing to its fast growth and the possibility of cultivation over a wider geographical range.

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The Ethnobotany and Chemistry of South African Meliaceae: A Review

Cited by 16 publications

References 113 publications

Sesquiterpenoids from Meliaceae Family and Their Biological Activities

Sesquiterpenoids from Meliaceae Family and Their Biological Activities

Evaluation of Wound Healing and Anti‐Inflammatory Activities of 80% Methanol Crude Extract and Solvent Fractions of Trichilia dregeana Sond (Meliaceae) Leaves in Mice

Research trends of Melia in tropical plantation forestry

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