The ethnopharmacological study of plant drugs used traditionally in Djibouti for malaria treatment

Elmi, Abdirahman; Said Mohamed, A.; Mérito, Ali; Charneau, Sébastien; Amina, Mohamed; Grellier, Philippe; Bouachrine, Mohammed; Lawson, Ata M.; Abdoul-Latif, Fatouma M.; Kordofani, Maha A.Y.

doi:10.1016/j.jep.2024.117839

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…However, in a situation of health emergency termed double-burden of disease [ 73 ] marginalized populations, in addition to combatting insurging life-style diseases, continue to fight neglected infectious diseases with botanical drugs [ 58 , 74 ]. Investigations of traditional treatments of rare and neglected parasitic and infectious diseases [ 75 – 78 ] deserve more attention by ethnobiologists and ethnopharmacologists because major pharmaceutical companies show little interest in developing medications for a segment of the population with limited purchasing power [ 79 ]. Clinical studies involving humans are beyond what single academic groups can do.…”

Section: Experimental Studies In the Context Of Ethnobiologymentioning

confidence: 99%

Are we romanticizing traditional knowledge? A plea for more experimental studies in ethnobiology

Leonti

2024

J Ethnobiology Ethnomedicine

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In answer to the debate question "Is ethnobiology romanticizing traditional practices, posing an urgent need for more experimental studies evaluating local knowledge systems?" I suggest to follow-up on field study results adopting an inclusive research agenda, and challenge descriptive data, theories, and hypotheses by means of experiments. Traditional and local knowledge are generally associated with positive societal values by ethnobiologists and, increasingly also by stakeholders. They are seen as a way for improving local livelihoods, biocultural diversity conservation and for promoting sustainable development. Therefore, it is argued that such knowledge needs to be documented, protected, conserved in situ, and investigated by hypothesis testing. Here I argue that a critical mindset is needed when assessing any kind of knowledge, whether it is modern, local, indigenous, or traditional.

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Section: Experimental Studies In the Context Of Ethnobiologymentioning

confidence: 99%

Are we romanticizing traditional knowledge? A plea for more experimental studies in ethnobiology

Leonti

2024

J Ethnobiology Ethnomedicine

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Antioxidant, Enzyme and Molecular Docking Tyrosinase Inhibitory Activities of Major Polyphenols in Boscia coriacea Graells, Grewia erythraea (Schweinf.) Chiov., Ochradenus baccatus Delile, and Orthosiphon pallidus Royle Ex Benth.

Elmi,

Zengin,

Said

et al. 2024

Chemistry & Biodiversity

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Boscia coriacea Graells (BC), Grewia erythraea (Schweinf.) Chiov. (GE), Ochradenus baccatus Delile(OB), and Orthosiphon pallidus Royle ex Benth. (OP) are medicinal plants used in Djibouti. They were evaluated to determine their total phenolic content (TPC), flavonoid content (TFC), and phytochemical profile using HPLC‐MS/MS. Additionally, their antioxidant capacity was assessed through five various methods. Enzymatic activities were also measured, focusing on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α‐amylase, α‐glucosidase, and tyrosinase. OP extract had the highest TPC and exhibited the best antioxidant capacity, while OB and BC extracts had the highest TFC. Twenty‐seven compounds were identified and quantified by LCMS. GE extract demonstrated the highest AChE activity, while OP extract had the highest BChE activity. BC was most active against α‐amylase and α‐glucosidase, and only GE and OP extracts showed tyrosinase inhibition Invitro. In silico analysis, the compounds were optimized and docked to the human tyrosinase‐related protein 1 using AutoDock Vina, with ADME to evaluate their suitability based on key therapeutic criteria. Chlorogenic, neochlorogenic, gallic acids and quercetin emerged as promising tyrosinase inhibitors. These plants can be a viable source in the prevention and treatment related to tyrosinase enzyme inhibition.

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Biodiversity, Traditional Uses, and Pharmacological Potential of Medicinal Plants of Mozambique

Razão,

Sánchez,

Naval

et al. 2024

Agriculture

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Mozambique possesses great biological diversity, with approximately 5500 plant species. Around 90% of its population uses natural resources for food and traditional medicine, being miombo forests serving as key providers for rural communities. The trade of medicinal plants also constitutes a significant economic activity for both rural and urban households. This study aims to review ethnobotanical and ethnopharmacological studies on medicinal plants in Mozambique and explore their agricultural and conservation potential. Articles published between 2010 and 2024 were included and identified 472 medicinal plant species, 400 of which were classified to species or genus level, spanning 277 genera and 93 botanical families. The most cited families include Leguminosae (61 species), Euphorbiaceae (20), and Combretaceae (17). Notable species are Momordica balsamina, Sclerocarya birrea, Annona senegalensis, and Cassia abbreviata. Sixteen in vitro studies explored medicinal plants’ antibacterial, antimycobacterial, antimicrobial, anticancer, and antimalarial properties. Prominent results were shown by Maerua edulis (tuberculosis), Tabernaemontana elegans (malaria), and Momordica balsamina (cancer). This work underscores the critical role of natural resources in Mozambique’s primary healthcare system and highlights their agricultural and economic potential. As the first comprehensive compilation of commonly used medicinal plants in the country, it calls for sustainable cultivation practices and further research to enhance their use and benefits.

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The ethnopharmacological study of plant drugs used traditionally in Djibouti for malaria treatment

Cited by 3 publications

References 31 publications

Are we romanticizing traditional knowledge? A plea for more experimental studies in ethnobiology

Are we romanticizing traditional knowledge? A plea for more experimental studies in ethnobiology

Antioxidant, Enzyme and Molecular Docking Tyrosinase Inhibitory Activities of Major Polyphenols in Boscia coriacea Graells, Grewia erythraea (Schweinf.) Chiov., Ochradenus baccatus Delile, and Orthosiphon pallidus Royle Ex Benth.

Biodiversity, Traditional Uses, and Pharmacological Potential of Medicinal Plants of Mozambique

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