The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of Rhaponticum uniflorum (Leuzea uniflora): A Comprehensive Review

Abstract

Rhaponticum uniflorum (L.) DC. (syn. Leuzea uniflora (L.) Holub) is a plant species of the Compositae (Asteraceae) family that is widely used in Asian traditional medicines in China, Siberia, and Mongolia as an anti-inflammatory and stimulant remedy. Currently, R. uniflorum is of scientific interest to chemists, biologists, and pharmacologists, and this review includes information from the scientific literature from 1991 to 2022. The study of the chemodiversity of R. uniflorum revealed the presence of 225 compounds, including sesquiterpenes, ecdysteroids, triterpenes, sterols, thiophenes, hydroxycinnamates, flavonoids, lignans, nucleosides and vitamins, alkanes, fatty acids, and carbohydrates. The most studied groups of substances are phenolics (76 compounds) and triterpenoids (69 compounds). Information on the methods of chromatographic analysis of selected compounds, as well as on the quantitative content of some components in various organs of R. uniflorum, is summarized in this work. It has been shown that the extracts and some compounds of R. uniflorum have a wide range of biological activities, including anti-inflammatory, antitumor, immunostimulatory, anxiolytic, stress-protective, actoprotective, antihypoxic, anabolic, hepatoprotective, inhibition of PPARγ receptors, anti-atherosclerotic, and hypolipidemic. Published research on the metabolites and bioactivity of R. uniflorum does not include clinical studies of extracts and pure compounds; therefore, an accurate study of this traditional medicinal plant is needed.

Hogweed Seed Oil: Physico–Chemical Characterization, LC-MS Profile, and Neuroprotective Activity of Heracleum dissectum Nanosuspension

“…Permanent focal cerebral ischemia caused by the right-sided thermocoagulation of the middle cerebral artery in rats reduces cerebral blood flow (1.25 sm/s vs. 4.10 sm/s in the sham-operated group; p < 0.05) and increases necrosis zone area to 41.52% ( Table 7 ). The application of a standardized extract of Ginkgo biloba (EGB761) demonstrated a positive effect characterized by increased cerebral blood flow (2.63 sm/s; p < 0.05) and reduction of necrosis zone area down to 21.60% ( p < 0.05), which is typical for the plant extracts with neuroprotective effects such as Ginkgo biloba [ 105 ], Rhaponticum uniflorum [ 106 ], Serratula centauroides [ 107 ], and Nepeta multifida [ 108 ]. The nanosuspension of HSO in doses of 0.1–1 mL/kg demonstrated a positive dose-dependent effect, which increased with dose.…”

Phenolic Compounds of Six Unexplored Asteraceae Species from Asia: Comparison of Wild and Cultivated Plants

“…Employing a similar globally used approach, scientists have successfully cultivated select Asteraceae species like Acmella oleracea [23], Ageratum conyzoides [24], Calendula officinalis [25], Tagetes minuta, T. patula, and T. erecta [26] for personal use. Furthermore, significant achievements in the cultivation of Siberian species include Artemisia frigida [27], Klasea centauroides [28], Parasenecio hastatus [29], and Rhaponticum uniflorum [30], all of which have found application in medicinal production.…”

Editorial for the Special Issue on Plant Polyphenols in the Immune and Inflammatory Responses

“…The authors mechanistically discussed the anti-SARS-CoV-2 and renoprotective activities of luteolin and highlighted its therapeutic potential for the treatment of AKI in COVID-19 patients. (3) "The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of Rhaponticum uniflorum (Leuzea uniflora): A Comprehensive Review"[27]. Dr. Olennikov analyzed the scientific literature from 1991 to 2022 on Rhaponticum uniflorum (L.) DC.(syn.…”