The Etiologic Relevance of 3-D Pathoanatomy of Adolescent Idiopathic Scoliosis

Schlösser, Tom P. C.; Brink, Rob C.; Castelein, René M.

doi:10.1590/s1808-185120171604183510

Cited by 5 publications

(2 citation statements)

References 68 publications

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“…11,30 Newer investigations have suggested that anterior overgrowth and overall scoliotic lordosis may be a more generalized deformity observed across all forms of scoliosis. 27,31 These correlation findings, in conjunction with the static local lordosis described previously, support a relationship between progression of coronal curvature and axial rotation, but not with sagittal kyphosis/lordosis.…”

Section: Deformitysupporting

confidence: 80%

“…This is of particular interest because the concept of asynchronous anterior overgrowth that produces the characteristic lordosis of the thoracic scoliotic spine had been previously suggested as an etiological driver of AIS deformity 11,30 . Newer investigations have suggested that anterior overgrowth and overall scoliotic lordosis may be a more generalized deformity observed across all forms of scoliosis 27,31 . These correlation findings, in conjunction with the static local lordosis described previously, support a relationship between progression of coronal curvature and axial rotation, but not with sagittal kyphosis/lordosis.…”

Section: Discussionsupporting

confidence: 57%

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Quantifying Typical Progression of Adolescent Idiopathic Scoliosis

Labrom,

Izatt,

Askin

et al. 2023

Spine

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Study Design. A prospective cohort study. Objective. Detail typical three-dimensional segmental deformities and their rates of change that occur within developing adolescent idiopathic scoliosis (AIS) spines over multiple timepoints. Summary of Background Data. AIS is a potentially progressive deforming condition that occurs in three dimensions of the scoliotic spine during periods of growth. However, there remains a gap for multiple timepoint segmental deformity analysis in AIS cohorts during development. Materials and Methods. Thirty-six female patients with Lenke 1 AIS curves underwent two to six sequential magnetic resonance images. Scans were reformatted to produce images in orthogonal dimensions. Wedging angles and rotatory values were measured for segmental elements within the major curve. Two-tailed, paired t tests compared morphologic differences between sequential scans. Rates of change were calculated for variables given the actual time between successive scans. Pearson correlation coefficients were determined for multidimensional deformity measurements. Results. Vertebral bodies were typically coronally convexly wedged, locally lordotic, convexly axially rotated, and demonstrated evidence of local mechanical torsion. Between the first and final scans, apical measures of coronal wedging and axial rotation were all greater in both vertebral and intervertebral disk morphology than nonapical regions (all reaching differences where P<0.05). No measures of sagittal deformity demonstrated a statistically significant change between scans. Cross-planar correlations were predominantly apparent between coronal and axial planes, with sagittal plane parameters rarely correlating across dimensions. Rates of segmental deformity changes between earlier scans were characterized by coronal plane convex wedging and convexly directed axial rotation. The major locally lordotic deformity changes that did occur in the sagittal plane were static between scans. Conclusions. This novel investigation documented a three-dimensional characterization of segmental elements of the growing AIS spine and reported these changes across multiple timepoints. Segmental elements are typically deformed from initial presentation, and subsequent changes occur in separate orthogonal planes at unique times.

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