The etiology and incidence of anaphylaxis in Rochester, Minnesota: A report from the Rochester Epidemiology Project

Decker, Wyatt W.; Campbell, Ronna L.; Manivannan, Veena; Luke, Anuradha; Sauver, Jennifer L. St.; Weaver, Amy L.; Bellolio, M. Fernanda; Bergstralh, Eric J.; Ganti, Latha; Li, James T.C.

doi:10.1016/j.jaci.2008.09.043

Cited by 359 publications

(332 citation statements)

References 14 publications

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“…Table 4 shows the sensitization pattern to common inhalant allergens observed in 481 patients (183 children and 298 adults), with no significant difference between children and adults. Discussion According to our data, the incidence of food anaphylaxis in the general population of Piemonte Region appears to be similar to the incidence reported in the literature, which range from 10.5 per 100,000 person year to 32 per 100,000 person year [14][15][16]. We cannot exclude underestimation of the true incidence of food anaphylaxis, in particular, milder forms.…”

Section: Resultssupporting

confidence: 82%

Incidence of food anaphylaxis in Piemonte region (Italy): data from registry of Center for Severe Allergic Reactions

et al. 2013

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There are wide differences in estimated incidence and prevalence of anaphylaxis because of the absence, until recently, of a universal consensus on the definition of anaphylaxis and the different source of collected data. We aimed to estimate the incidence of food anaphylaxis based on the database of Piemonte Region (Italy) Reference Center for Severe Allergic Reactions. All cases of severe food allergic reactions reported in 2010 were studied. Clinical data associated to the reports were evaluated according to National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network diagnostic criteria of anaphylaxis. 75 % of the 778 cases were classified as food anaphylaxis (incidence of 13/100,000 personyears, ranging from 9.9 in adults to 29/100,000 person-years in children). Nuts were the most frequent foods causing anaphylaxis. Milk and eggs were responsible for anaphylaxis more often in children, while peach, vegetables and crustaceans were in adults. Cardiovascular symptoms were more frequent in adults. Gastrointestinal involvement was more frequent in children. A high prevalence of respiratory allergic comorbidities was observed. Food is an important cause of anaphylaxis, particularly in subjects with respiratory allergic comorbidities. Children and adults differ in triggers and clinical presentation of anaphylaxis.Keywords: Anaphylaxis, Food allergy, Epidemiology, Allergy Introduction Population-based studies estimate the incidence of anaphylaxis in western countries to be in the range of 4-50 per 100,000 person-years [1, 2], with a true lifetime prevalence in the range of 0.05-2 % [3]. Foods are reported to be the most important trigger of anaphylaxis, being responsible for 33.2-56 % of all anaphylaxis cases [4]. The other two principal triggers of anaphylaxis are insect stings and drugs [1,5]. The relative contribution of each of these triggers to anaphylaxis may differ according to the study design, study population, or geographic area. The wide differences in the estimated incidences and prevalences of anaphylaxis are the direct result of the absence, until recently, of a universal consensus on the definition of anaphylaxis and the different source of collected data. For this reason in 2005 the National Institute of Allergy and Infectious Disease (NIAID) and the Food Allergy and Anaphylaxis Network (FAAN) developed a very useful preliminary definition, based on diagnostic criteria [6]. The symposium defined anaphylaxis as: "a serious allergic reaction that is rapid in onset and may cause death". Clinically, involvement of at least two organs (skin or mucosal tissue, cardiovascular apparatus, breathing apparatus, gastrointestinal tract) is required, or a sudden reduced blood pressure along with a temporal relationship (generally minutes) to a potential causative agent. A problematic issue with this definition, which may explain the under-reporting or misreporting of anaphylaxis cases, is the failure to agree among health care providers on the severity threshold for classi...

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Section: Resultssupporting

confidence: 82%

Incidence of food anaphylaxis in Piemonte region (Italy): data from registry of Center for Severe Allergic Reactions

et al. 2013

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“… The faster the onset of an anaphylactic reaction, the greater the likelihood that it will be severe [1][2][3][4][5][6].…”

Section: Speed Of Potentially Fatal Anaphylaxismentioning

confidence: 99%

Immunotherapy Monitoring Through Liposomes-An Altered Form of Bio-Sensing

Sk¹

2012

J Aller Ther

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“…The most severe reactions Table 1 Food is a frequent cause of anaphylaxis. Proportion of cases involving food as reported in the literature (12,(32)(33)(34) Study Location Thirteen of the reactions to food featured fatal anaphylaxis, eight of which have been described in detail (19). The causative foods were peanuts (four deaths), soy (four deaths), hazelnut (two deaths) and milk (two deaths) with one unknown cause (20).…”

Section: Swedenmentioning

confidence: 99%

Towards a European registry of severe allergic reactions: current status of national registries and future needs

Worm

Timmermans²,

Moneret-Vautrin

et al. 2010

Allergy

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Allergies are among the most common diseases and food allergy as a common cause of severe allergic reactions is estimated to affect between 2% and 4% of the population of industrialized countries, with a prevalence of up to 8% in children. The burden on those directly affected, as well as on their families, is being increasingly recognized (1). Ongoing research is likely to provide accurate and reliable information on the size of the population at risk, as well as the importance of different allergenic foods. Research is also generating information about the distribution of minimum eliciting doses within the allergic population for the more common allergenic foods.The present lack of data impairs estimation of the public health impact of allergic reactions in general and in particular reactions to foods. The effectiveness of allergen control measures and educational efforts for prevention are difficult to evaluate and prioritise. Absence of such information also affects the clinical management of allergic reactions, as experience with regard to treatment, circumstances and etiological agents is not collected systematically and effectively. The present article examines the systems that have been put in place in several European countries for recording severe allergic reactions. It then considers the type of information that such registries should hold to meet the needs of different stakeholders (clinical, public health, regulatory, industrial) and outlines a proposal for a pan-European registry of severe allergic reactions. Severe allergic reactions -a public health problem in EuropeAnaphylaxis is the most severe manifestation of an allergic reaction (2). It may occur following exposure to allergens from a variety of sources including foods, insect venom, drugs and others. An international symposium acknowledged AbstractThe incidence of severe allergic reactions is largely unknown and information about triggering allergens, aggravating factors, demography of patients and medical care is lacking. A European wide registry could provide a powerful tool to improve the management of severe allergic reactions from both a medical and a public health perspective. Analysis of existing registries regarding the type and quality of data being collected was used to develop a plan for a pan-European registry, including the type of system to be used and the range of data to be entered. Surveillance will provide evidence for the efficacy of risk management measures and may identify the emergence of new allergenic foods, and aid monitoring of novel foods, ingredients and technologies. Patients need a clear indication of factors that may increase their risk of having an adverse reaction, which such a registry can help compile. Based on the collected data, food businesses will be able to develop educational programmes for allergen risk assessment and allergen risk communication. Finally, and most importantly preventive measures can be developed and government agencies receive population based data which may be relevant for legisla...

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The etiology and incidence of anaphylaxis in Rochester, Minnesota: A report from the Rochester Epidemiology Project

Abstract: Background-Reported incidences of anaphylaxis range from 3.2 to 20 per 100,000 population. The incidence and trend over time has meaningful public health implications but has not been well characterized because of a lack of a standard definition and deficiencies in reporting of events.

Cited by 359 publications

References 14 publications

Incidence of food anaphylaxis in Piemonte region (Italy): data from registry of Center for Severe Allergic Reactions

Incidence of food anaphylaxis in Piemonte region (Italy): data from registry of Center for Severe Allergic Reactions

Immunotherapy Monitoring Through Liposomes-An Altered Form of Bio-Sensing

Towards a European registry of severe allergic reactions: current status of national registries and future needs

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