The Ets family of transcription factors

Wasylyk, Bohdan; Hahn, Soonjung L.; Giovane, Antoine

doi:10.1007/978-3-642-78757-7_2

Cited by 120 publications

(184 citation statements)

References 114 publications

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“…The results of the antisense inhicells, 7,8 cellular ETS-1 is expressed in immature hematopoietic cells of the erythroid lineage as well as in hematopoietic bition experiments argue that ETS-1 is essential for this response, and are also interesting considering the current tissues in the developing mouse, 30,31,58,59 and it has recently been reported that the MafB gene product binds to the DNA axiom that Ara-C induces an erythroid phenotype by inhibiting DNA replication, while hemin utilizes mechanisms binding domain of ETS-1 and inhibits erythroid differentiation of chicken hematopoietic progenitors. 60 It was suggested that which are different from those of Ara-C. [63][64][65][66][67] Our finding that ETS-1 expression contributes to the hemoglobinization in MafB is an interaction partner and repressor of ETS-1, and that is elevated expression inhibits erythroid differentiation.…”

Section: Discussionmentioning

confidence: 98%

ETS-1 induces increased expression of erythroid markers in the pluripotent erythroleukemic cell lines K562 and HEL

et al. 1997

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Members of the ETS gene family are known to be expressed in other members of the ETS gene family may have crucial roles hematopoietic tissues and cell lines, and there is increasing in specific aspects of hematopoietic cell development. evidence that ETS proteins may play a role in normal hemato-The c-ETS-1 gene, the cellular homolog to v-ets, is poietic cell development. We demonstrate that ETS-1 can conexpressed primarily as two major transcripts of 6.8 and 2.7 kb, virus with erythroleukemia and with the regulation of

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Section: Discussionmentioning

confidence: 98%

ETS-1 induces increased expression of erythroid markers in the pluripotent erythroleukemic cell lines K562 and HEL

et al. 1997

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“…Fli1 is a member of the Ets family of transcription factors that share a highly conserved Ets DNA binding domain and binds to Ets binding sites (EBS) that contain the core recognition motif GGA(A/T) (Brown and McKnight, 1992;Fisher et al, 1992;Mao et al, 1994;Shore and Sharrocks, 1995;Urness and Thummel, 1990;Wasylyk et al, 1993). Murine Fli1 was first identified as a proto-oncogene as a site for retroviral integration of Friend virus-induced erythroleukemias (Ben-David et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes

Nowling¹,

Fulton²,

Chike-Harris³

et al. 2008

Molecular Immunology

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Fli1 is an Ets family member that is essential for embryonic development. Increasing evidence suggests modulating Fli1 gene expression impacts lymphocyte development/function and is an important mediator in the autoimmune disease lupus. Fli1 is over-expressed in splenic lymphocytes in lupus prone mouse strains and in PBMCs of lupus patients. Presently, it is unknown how Fli1 gene expression is controlled in lymphocytes or how it becomes over-expressed in lupus. Therefore, we examined Fli1 regulation in a murine B cell line and T cell line and identified several cis-regulatory elements within a 230 bp region that contribute to Fli1 promoter activity. Ets factors Elf1, Tel and Fli1 bind in vitro to this region and increase endogenous Fli1 expression when over-expressed in a T cell line. In addition, we determined that a microsatellite located adjacent to the region containing these cis-regulatory elements is polymorphic in three lupus prone mouse strains and that the length of the microsatellite is inversely correlated with promoter activity in a T cell line. These results suggest that several Ets factors, including Fli1 itself, are involved in the transcriptional regulation of Fli1 in lymphocytes. Furthermore, the presence of a polymorphic microsatellite in the Fli1 promoter may contribute to increased Fli1 expression in T cells during lupus disease progression.

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“…Ets factors are known to play roles in skeletal development, haematopoiesis, neural synapse formation, immunomodulation, metastasis, cellular proliferation and differentiation, and apoptosis [12][13][14]. Some members of this family have also been implicated in tumorigenesis [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…Ets factors contain a conserved ETS DNA-binding (ETS) domain of 85 amino acids, which recognizes a core sequence of 5'-GGA(A/T)-3' in the ETS binding site (EBS) of target gene(s) [16][17][18][19][20]. Additional characteristics, such as the MAPK sites within PEA3 [21], the phosphorylation site within Ets-1 [22], or the Pointed (PNT) domain (a protein-binding domain) in Ets-1 [23], aid in target gene recognition and/or protein-protein interactions.…”

Section: Introductionmentioning

confidence: 99%

Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1

YANIW,

2005

Cell Res

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The role of Ese-2, an Ets family transcription factor, in gene regulation is not known. In this study, the interaction between Ese-2 and cytokeratin 18 (K18) intron 1 was characterized in lung epithelial cells. Reporter gene assays showed Ese-2 was able to upregulate K18 intron 1 enhanced reporter gene expression by approximately 2-fold. We found that full length Ese-2 did not bind DNA strongly, therefore truncated versions of the protein, containing the ETS domain or Pointed domain, were created and tested in electrophoresis mobility shift assays. Multiple interactions between the ETS domain and putative DNA binding sites within K18 intron 1 were observed, which led to the determination of a possible Ese-2 DNA binding consensus sequence. These experiments suggest that Ese-2 could play a role in the regulation of K18 expression in lung epithelial cells.

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The Ets family of transcription factors

Cited by 120 publications

References 114 publications

ETS-1 induces increased expression of erythroid markers in the pluripotent erythroleukemic cell lines K562 and HEL

ETS-1 induces increased expression of erythroid markers in the pluripotent erythroleukemic cell lines K562 and HEL

Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes

Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1

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