The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium

Stevens, Cody A.; Revaitis, Nicole T.; Caur, Rumkan; Yakoby, Nir

doi:10.1242/dev.189787

Cited by 5 publications

(1 citation statement)

References 65 publications

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“…In this way, there is sufficient Upd early on to fulfill the JAK-STAT signaling role in interfollicular stalk formation, while by stage 7, the amount of Upd is calibrated to generate a morphogen gradient at both poles (Besse and Pret, 2003;Borensztejn et al, 2013). Consequently, three adjacent somatic cell types, border cells (BCs), stretch cells, and centripetal cells, are specified at the anterior pole, while posterior cells adopt a different fate due to the combined outputs of JAK-STAT and EGFR signaling (Xi et al, 2003;Fregoso Lomas et al, 2016;Stevens et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway during Drosophila oogenesis

Mallart

Chalvet

Netter

et al. 2022

Front. Cell Dev. Biol.

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The JAK-STAT pathway is evolutionary conserved. The simplicity of this signaling in Drosophila, due to the limited redundancy between pathway components, makes it an ideal model for investigation. In the Drosophila follicular epithelium, highly stereotyped functions of JAK-STAT signaling have been well characterized, but how signaling activity is regulated precisely to allow the different outcomes is not well understood. In this tissue, the ligand is secreted by the polar cells positioned at each follicle extremity, thus generating a gradient of JAK-STAT activity in adjacent cells. One way to control the delivered quantity of ligand is by regulating the number of polar cells, which is reduced by apoptosis to exactly two at each pole by mid-oogenesis. Hence, JAK-STAT activity is described as symmetrical between follicle anterior and posterior regions. Here, we show that JAK-STAT signaling activity is actually highly dynamic, resulting in asymmetry between poles by mid-oogenesis. Interestingly, we found similar temporal dynamics at follicle poles in the accumulation of the adherens junction E-cadherin protein. Remarkably, E-cadherin and JAK-STAT signaling not only display patterning overlaps but also share functions during oogenesis. In particular, we show that E-cadherin, like JAK-STAT signaling, regulates polar cell apoptosis non-cell-autonomously from follicle cells. Finally, our work reveals that E-cadherin is required for optimal JAK-STAT activity throughout oogenesis and that E-cadherin and Stat92E, the transcription factor of the pathway, form part of a physical complex in follicle cells. Taken together, our study establishes E-cadherin as a new positive regulator of JAK-STAT signaling during oogenesis.

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Section: Introductionmentioning

confidence: 99%

E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway during Drosophila oogenesis

Mallart

Chalvet

Netter

et al. 2022

Front. Cell Dev. Biol.

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Stochastic phenotypes in RAS-dependent developmental diseases

et al. 2023

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A Unifying Framework for Understanding Biological Structures and Functions Across Levels of Biological Organization

Herman

Aiello

DeLong

et al. 2021

Integrative and Comparative Biology

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The relationship between structure and function is a major constituent of the rules of life. Structures and functions occur across all levels of biological organization. Current efforts to integrate conceptual frameworks and approaches to address new and old questions promise to allow a more holistic and robust understanding of how different biological functions are achieved across levels of biological organization. Here, we provide unifying and generalizable definitions of both structure and function that can be applied across all levels of biological organization. However, we find differences in the nature of structures at the organismal level and below as compared to above the level of the organism. We term these intrinsic and emergent structures, respectively. Intrinsic structures are directly under selection, contributing to the overall performance (fitness) of the individual organism. Emergent structures involve interactions among aggregations of organisms and are not directly under selection. Given this distinction, we argue that while the functions of many intrinsic structures remain unknown, functions of emergent structures are the result of the aggregate of processes of individual organisms. We then provide a detailed and unified framework of the structure-function relationship for intrinsic structures to explore how their unknown functions can be defined. We provide examples of how these scalable definitions applied to intrinsic structures provide a framework to address questions on structure-function relationships that can be approached simultaneously from all subdisciplines of biology. We propose that this will produce a more holistic and robust understanding of how different biological functions are achieved across levels of biological organization.

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The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium

Cited by 5 publications

References 65 publications

E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway during Drosophila oogenesis

E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway during Drosophila oogenesis

Stochastic phenotypes in RAS-dependent developmental diseases

A Unifying Framework for Understanding Biological Structures and Functions Across Levels of Biological Organization

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