In traditional male-dominated society women generally enjoy secondary status in familial and social hierarchy. The widespread condition of gender disparity may be attributed to a lack of gainful employment and fixed wages with a regular source of livelihood. The majority of women are left out of the ambit of the decision-making process due to their inferior social and economic conditions. The status of women can be raised and gender equality can be achieved through MSME which empowers women with upward movement in economic, social and political hierarchy. MSME facilitates women entrepreneurs to utilise their entrepreneurial skills and talent and to play leadership roles to improve the conditions of women folk. The present study focuses on the role of leading women entrepreneurs of Puri district Odisha towards the objective of empowering women. The data gathered through questionnaires, surveys, person to person interaction during field visits/workshops/seminars/presentations form the basis for developing this article. During interaction all points raised, views expressed by respondents, and suggestions gathered were recorded to organize this article. It has been observed MSME sectors have largely contributed to improving women's status through employment, skill upgradation, innovations, and encouraging participative and collaborative decisions. However, simplifying and streamlining activities related to registration, products, production, financing, training, and marketing would enhance further value addition by MSME. The insights earned during the study about ground realities, problem areas, and steps towards a solution will help the researchers, NGOs, SHGs, field agencies, donors, bankers, government institutions, corporate houses, and planners to fine-tune their approach towards women empowerment.