The eukaryotic initiation factor 4E (eIF4E) binding domain of eIF4GI enhances recruitment and discrimination among a subset of mRNAs containing structured 5’UTRs
Abstract:Protein translation is an energy demanding process in the cells and plays a vital role in regulation of gene expression. During canonical translation initiation, eukaryotic initiation factor 4G (eIF4GI) plays a central role in recruitment of various initiation factors to mRNA. During cellular stress conditions, canonical cap‐dependent translation is suppressed by triggering overexpression of 4E binding protein (4EBP) and increasing 4EBP mediated sequestration of eIF4E. Under this condition, a subset of cellula… Show more
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