The European human biomonitoring platform - Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals

López, Marta Esteban; Göen, Thomas; Mol, Hans; Nübler, Stefanie; Haji-Abbas-Zarrabi, Karin; Koch, Holger M.; Kasper-Sonnenberg, Monika; Dvořáková, Darina; Hajšlová, Jana; Antignac, Jean‐Philippe; Vaccher, Vincent; Elbers, I.J.W.; Thomsen, Cathrine; Vorkamp, Katrin; Díaz, Susana Pedraza; Kolossa-Gehring, Marike; Castaño, Argelia

doi:10.1016/j.ijheh.2021.113740

Cited by 88 publications

(49 citation statements)

References 22 publications

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“…Potential differences in HBM data from different countries may be ascribed to methodological procedures and population characteristics, as previously highlighted [30]. The BPA analytical method was validated within the proficiency tests organized by the Quality Assurance Unit in the HBM4EU project [20]; thus, any possible bias due to analytical determination can be ignored. With respect to population characteristics, in LIFE PERSUADED, data were evaluated not only by residing area, but also according to sex and age categories, and taking into account body weight and creatinine levels, which are associated with a child's age [22,31].…”

Section: Discussionmentioning

confidence: 99%

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Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project

Tait

Carli

Busani

et al. 2021

IJERPH

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A human biomonitoring (HBM) study on bisphenol A (BPA) in Italian children and adolescents was performed within the LIFE PERSUADED project, considering the residing areas, sex and age. The median urinary BPA level was 7.02 µg/L, with children living in the South of Italy or in urban areas having higher levels than those residing in the North or in rural areas. Children aged 4–6 years had higher BPA levels than those aged 7–10 and 11–14 years, but no differences were detected between sexes. The exposure in Italian children was higher compared to children from other countries, but lower than the HBM guidance value (135 µg/L). The estimated daily intake was 0.17 μg/kg body weight (bw) per day, about 24-fold below the temporary Tolerable Daily Intake of 4 μg/kg bw per day established by the European Food Safety Authority. However, this threshold was exceeded in 1.44% of the enrolled children, raising concern about the overall exposure of Italian young population.

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Section: Discussionmentioning

confidence: 99%

“…The analytical method was validated in a proficiency test organized by the HBM4EU Project within the Quality Assurance and Quality Control program, with good results. (https: //www.hbm4eu.eu/online-library/?mdocs-cat=mdocs-cat-20&mdocs-att=null# accessed on 20 October 2021) [20].…”

Section: Methodsmentioning

confidence: 99%

Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project

Tait

Carli

Busani

et al. 2021

IJERPH

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“…For this we will analyse chromium, cadmium, lead and mercury in urine and hair and chromium, cadmium and lead in blood (see Table 2 ). The analysis of cadmium in blood and urine and chromium in blood, serum and urine were supported in [ 32 ]. To explore primary and secondary sources and routes of exposure and for better interpretation of the biomonitoring outcome of inhalable and respirable dust, settled dust and hand wipes will be analysed for the above-mentioned metals.…”

Section: Methodsmentioning

confidence: 99%

HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol

Scheepers

Duca

Galea

et al. 2021

IJERPH

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Workers involved in the processing of electronic waste (e-waste) are potentially exposed to toxic chemicals. If exposure occurs, this may result in uptake and potential adverse health effects. Thus, exposure surveillance is an important requirement for health risk management and prevention of occupational disease. Human biomonitoring by measurement of specific biomarkers in body fluids is considered as an effective method of exposure surveillance. The aim of this study is to investigate the internal exposure of workers processing e-waste using a human biomonitoring approach, which will stimulate improved work practices and contribute to raising awareness of potential hazards. This exploratory study in occupational exposures in e-waste processing is part of the European Human Biomonitoring Initiative (HBM4EU). Here we present a study protocol using a cross sectional survey design to study worker’s exposures and compare these to the exposure of subjects preferably employed in the same company but with no known exposure to industrial recycling of e-waste. The present study protocol will be applied in six to eight European countries to ensure standardised data collection. The target population size is 300 exposed and 150 controls. Biomarkers of exposure for the following chemicals will be used: chromium, cadmium and lead in blood and urine; brominated flame retardants and polychlorobiphenyls in blood; mercury, organophosphate flame retardants and phthalates in urine, and chromium, cadmium, lead and mercury in hair. In addition, the following effect biomarkers will be studied: micronuclei, epigenetic, oxidative stress, inflammatory markers and telomere length in blood and metabolomics in urine. Occupational hygiene sampling methods (airborne and settled dust, silicon wristbands and handwipes) and contextual information will be collected to facilitate the interpretation of the biomarker results and discuss exposure mitigating interventions to further reduce exposures if needed. This study protocol can be adapted to future European-wide occupational studies.

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“…Additionally, the comparability and quality of the biomarker measurements performed within the joint HBM4EU survey is controlled at the EU level. Briefly, the biomarkers must be analysed in laboratories that successfully participated in the interlaboratory comparison investigation/external quality assurance scheme (ICI/EQUAS) organized as part of the HBM4EU initiative which is described by Esteban et al ( Esteban López, 2021 ). Participating analytical laboratories had to participate in at least two proficiency tests.…”

Section: Method: Aligning European Hbm Surveysmentioning

confidence: 99%

HBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity – The HBM4EU survey

Gilles

Govarts

Rambaud

et al. 2021

International Journal of Hygiene and Environmental Health

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As part of the Human Biomonitoring for Europe (HBM4EU) initiative a human biomonitoring (HBM) survey is conducted in 21 countries. This survey builds on existing HBM capacity in Europe by aligning national or regional HBM studies. The survey targets 3 age groups (i) children aged 6–11 years, (ii) teenagers aged 12–19 years and (iii) young adults aged 20–39 years and includes a total of 9493 participants (3151 children, 2953 teenagers and 3389 young adults). Depending on the age group, internal exposure to phthalates and substitute Hexamoll® DINCH, brominated and organophosphorus flame retardants, per-/poly-fluorinated compounds, cadmium, bisphenols and/or polycyclic aromatic hydrocarbons are assessed. The main goal of the programme is to obtain quality controlled and comparable HBM data of exposure to chemicals, prioritized under HBM4EU, with European wide coverage to inform the development of environment and health policies. This paper describes the framework of the HBM4EU survey and the approach that has been applied to align European HBM initiatives across Europe.

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The European human biomonitoring platform - Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals

Cited by 88 publications

References 22 publications

Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project

Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project

HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol

HBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity – The HBM4EU survey

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