The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): first EUROMACS Paediatric (Paedi-EUROMACS) report

By, Theo M M H de; Antonides, Christiaan F J; Schweiger, Martin; Śliwka, Joanna; Davies, Ben; Berger, Felix; Hübler, Michael; Özbaran, Mustafa; Maruszewski, Bohdan; Napoleone, Carlo Pace; Zimpfer, Daniel; Sandica, Eugen; Antretter, Herwig; Meyns, Bart; Miera, Oliver

doi:10.1093/ejcts/ezy298

Cited by 44 publications

(40 citation statements)

References 11 publications

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“…Twenty-nine centres contributed data to this second paediatric report, an increase of 20%. Device strategies as well as device characteristics have not changed considerably [1].…”

Section: Discussionmentioning

confidence: 99%

“…The methods to ensure data reliability were mentioned in the first Paedi-EUROMACS Report [1]. In summary, these include statistical consistency and plausibility checks, on-site audits and feedback reports and update status per patient for each participant.…”

Section: Data Quality Checks and Auditsmentioning

confidence: 99%

“…The quantity of data for paediatric patients who suffer from endstage heart failure treated with mechanical circulatory support (MCS) continues to grow. Because the number of patients implanted with a ventricular assist device (VAD) per centre remains relatively limited, the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) provides a platform to collect data from multiple centres across Europe [1]. Within its Quality Improvement Programme, the European Association for Cardio-Thoracic Surgery provides the structure for the collection and registration of both paediatric and adult data of patients who receive MCS.…”

Section: Introductionmentioning

confidence: 99%

“…Because an increasing number of patients are ongoing on durable VADs, this second EUROMACS paediatric report includes the data from the first report [1] and includes adverse events and end points after 31 December 2017.…”

Section: Introductionmentioning

confidence: 99%

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The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): second EUROMACS Paediatric (Paedi-EUROMACS) report

By¹,

Antonides

Schweiger

et al. 2020

European Journal of Cardio-Thoracic Surgery

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OBJECTIVES A second paediatric report has been generated from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). The purpose of EUROMACS, which is operated by the European Association for Cardio-Thoracic Surgery, is to gather data related to durable mechanical circulatory support for scientific purposes and to publish reports with respect to the course of mechanical circulatory support therapy. Since the first report issued, efforts to increase compliance and participation have been extended. Additionally, the data provided the opportunity to analyse patients of younger age and lower weight. METHODS Participating hospitals contributed pre-, peri- and long-term postoperative data on mechanical circulatory support implants to the registry. Data for all implants in paediatric patients (≤19 years of age) performed from 1 January 2000 to 1 July 2019 were analysed. This report includes updates of patient characteristics, implant frequency, outcome (including mortality rates, transplants and recovery rates) as well as adverse events including neurological dysfunction, device malfunction, major infection and bleeding. RESULTS Twenty-nine hospitals contributed 398 registered implants in 353 patients (150 female, 203 male) to the registry. The most frequent aetiology of heart failure was any form of cardiomyopathy (61%), followed by congenital heart disease and myocarditis (16.4% and 16.1%, respectively). Competing outcomes analysis revealed that a total of 80% survived to transplant or recovery or are ongoing; at the 2-year follow-up examination, 20% died while on support. At 12 months, 46.7% received transplants, 8.7% were weaned from their device and 18.5% died. The 3-month adverse events rate was 1.69 per patient-year for device malfunction including pump exchange, 0.48 for major bleeding, 0.64 for major infection and 0.78 for neurological events. CONCLUSIONS The overall survival rate was 81.5% at 12 months following ventricular assist device implant. The comparison of survival rates of the early and later eras shows no significant difference. A focus on specific subgroups showed that survival was less in patients of younger age (<1 year of age) (P = 0.01) and lower weight (<20 kg) (P = 0.015). Transplant rates at 6 months continue to be low (33.2%) The fact that the EUROMACS registry is embedded within the European Association for Cardio-Thoracic Surgery Quality Improvement Programme offers opportunities to focus on improving outcomes.

show abstract

“…Twenty-nine centres contributed data to this second paediatric report, an increase of 20%. Device strategies as well as device characteristics have not changed considerably [1].…”

Section: Discussionmentioning

confidence: 99%

Section: Data Quality Checks and Auditsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): second EUROMACS Paediatric (Paedi-EUROMACS) report

By¹,

Antonides

Schweiger

et al. 2020

European Journal of Cardio-Thoracic Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

“…According to current European and North American registry reports, approximately 50% of children with CF LVADs support undergo heart transplantation within 3 to 6 months of initiation of mechanical support. [2][3][4]6 This may explain and support the high success rate of outcomes associated with this MCS strategy.…”

mentioning

confidence: 67%