The evaluation of a biodegradable dental chip containing chlorhexidine in chitosan base as a targeted drug delivery in the management of chronic periodontitis in patients

Abstract

Chlorhexidine is one of the commonly used agents in the treatment of periodontitis. In the present study, a biodegradable dental chip of chitosan containing chlorhexidine was evaluated both in vitro and in vivo, as a targeted drug delivery system in patients of chronic periodontitis. Thirty patients having localized periodontal pockets Z5 mm were selected. At baseline, the experimental patients received full mouth scaling and root planing followed by placement of a chlorhexidine chip. The placebo group received plain chitosan chips, and conventional scaling and root planing were performed for the control group. Measurements of plaque, gingival index were recorded at 1, 2, 3, and 4 months. Probing depth and clinical attachment levels were recorded at the 3rd and 4th month. GCF and saliva samples were procured from the subjects to analyze the drug release at 0, 2, 4, 6, and 24 h and on days 2, 3, 5, 7, 9, 11, 13, 15, 30, 60, and 90. The study showed improvement in plaque index, gingival index, probing depth, and clinical attachment levels, but the chlorhexidine chip-treated group showed a significantly better improvement than placebo and control groups at the end of 120 days. Based on the results of the present in vivo study, we can conclude that the chlorhexidine-containing chitosan drug delivery system may be an adjunct in treating patients with chronic periodontitis. Drug Dev Res 70 : 395-401, 2009.

Formulation and Evaluation of a New Biodegradable Periodontal Chip Containing Thymoquinone in a Chitosan Base for the Management of Chronic Periodontitis

“…These studies reported mean PD decreases of 0.84 mm and 0.80 mm, respectively. Our results are also in agreement with studies performed by [6,15,24] using periodontal chips containing chlorhexidine as local delivery agents in the management of chronic periodontitis. These previous studies demonstrated that when a biodegradable chlorhexidine chip is used as an adjunct to conventional periodontal therapy critical enhancements are obtained in periodontal probing depths and attachment levels compared to the use of scaling and root planning alone.…”

“…After drying overnight at room temperature, the resultant film was cut into small rectangular chips 0.5 × 0.5 sq⋅cm in size and 0.16 ± 0.02 mm thick. These chips were then covered in aluminum foil and kept in sterile vials at room temperature [15].…”

In vitroevaluation of osteoprotegerin in chitosan for potential bone defect applications

“…Clinically, chitosan also has high potential in dental applications, and it has used to repair socket after dental extraction (Ezoddini-Ardakani, 2011). Other research also reported that biodegradable dental chip containing chlorhexidine or thymoquinone was applied for management of chronic periodontitis in patients (Al-Bayaty et al, 2013; Jothi et al, 2009). …”

Bioactive Glasses and their Applications in Dentistry

“…Antimicrobial agents are commonly used for various dental procedure such as endodontic 41,42 and periodontic treatments 43,44 . The use of BG can increase the pH of the aqueous solution and generate antimicrobial effects.…”