The evaluation of a new marker of transmyocardial repolarization parameters in ischemic stroke patients; T peak–T end (T p-e), T p-e/QTc

Abstract

The cardiovascular manifestations of acute ischemic stroke have been well known. Several electrocardiography (ECG) abnormalities have been reported in patients following acute stroke, including QT interval prolongation, ST segment deviation and T-wave changes. This study aimed to investigate the changes in transmyocardial repolarization parameters, in ischemic stroke patients. The study is a prospective, blind, and controlled clinical study. The patients without cardiac disease who received ischemic stroke diagnoses were included in the study. ECG was received from the patients in the first hour and 72 h. The P, QT, T , T dispersion, and the T /QT ratio were calculated. Moreover, fifty-five stroke patients and 35 control subjects were included to the study. All dispersion values and T/QT ratio in patients group were higher than those of control group (p < 0.05 for all values). When evaluated between ECGs' on first and third days, it was found that decreasing on all dispersion values and T /QT ratio in ECGs on third day than ECGs on first day (p < 0.05 for all values). QT, QT, and T dispersions values in patients who have insular lobe involvement were higher than those of patients who do not have insular lobe involvement (p< 0.001 for all values). In this study, we showed that acute stroke increases that P , QT, QT and new repolarization markers T and T/QT, during first 24 and 72 h in acute stroke patients without cardiovascular disease compared with the control group. The physicians should be aware about ventricular dysrhythmias in patients with ischemic stroke and these patients closely observed with cardiac monitoring, especially within first 24 h, and especially patients with insular lobe involvement.

Association of trans-myocardial repolarisation parameters with size of the diffusion limitation area in acute ischaemic stroke

“…We have already carried out a study in our own department. This, and other studies in the literature, have shown a prolonged range of transmyocardial repolarisation parameters that have been proven to be associated with ventricular arrhythmias and sudden cardiac death in stroke patients [13,20,21]. In addition, these parameters were evaluated not only for stroke, but also for stroke severity, type, localisation, and prognostic value.…”

Akut iskemik inmeli hastalarda repolarizasyon parametreleri ile inme şiddeti arasındaki ilişki

“…In this study, we found that, QTc, QTd, QTcd parameters are positively correlated with stroke severity. Emektar et al found that Tpe and Tpe/QTc parameters were significantly higher in acute ischemic stroke patients than control groups 25 . In our study, we found that Tpe and Tpe/QT parameters are positively correlated with stroke severity.…”

The cerebrovascular, neuroprotective and antiarrhythmic properties of the anxiolytic fabomotizole

“…Учитывая цереброваскулярную эффективность афобазола при сосудистой патологии мозга и сердца, а также взаимосвязь между цереброваскулярными расстройствами и нарушениями функции сердца [44][45][46][47][48] были изучены антиаритмические свойства препарата.…”