The Evaluation of Angiotensin-Converting Enzyme Inhibitors in Renal Elimination with Selected Molecular Descriptors

Abstract

Angiotensin-converting enzyme (ACE) inhibitors modulate the function of the renin-angiotensin-aldosterone system, and they are commonly prescribed antihypertensive drugs especially in patients with renal failure. In this study, the relationships between several molecular properties of eight ACE inhibitors (enalapril, quinapril, fosinopril, ramipril, benazepril, perindopril, moexipril, trandolapril) SAŽETAK Inhibitori enzima koji konvertuje angiotenzin (ACE) modifi kuju funkciju renin-angiotenzin-aldosteron sistema i predstavljaju često propisane lekova za sniženje pritiska, posebno kod pacijenata sa insufi cijencijom bubrega. U ovom radu, za osam odabranih ACE inhibitora (enalapril, kvinapril, fosinopril, ramipril, benazepril, perindopril, moeksipril, trandolapril)

A Study of Absorption and Selected Molecular Physicochemical Properties of Some Antipsychotic Drugs

“…In our prior researches, influence of several molecular physicochemical properties on absorption (13)(14)(15), plasma protein binding (16,17) as well as route of elimination (18)(19)(20) were investigated for number of antihypertensive drugs and significant dependence was established. Following in our recently published paper we studied relationship between antipsychotics molecular properties and their plasma protein binding degree (21).…”