The Evaluation of Antitussive Agents

Brunk, S. Fred

doi:10.1002/j.1552-4604.1973.tb00216.x

Cited by 1 publication

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“…Re cently, Picken and associates reported observations indicating 'although the mechanism is not clear, it is apparent that viral infections of the upper respiratory tract may be followed in normal men by prolonged changes in small airway dynamics' [36], implying the utility of critical measurements for the study of acute respiratory infections.…”

Section: Discussionmentioning

confidence: 99%

Respiratory and Cough Mechanics in Antitussive Trials

Cohen¹

1975

Respiration

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The relative responsitivy of nine expirographic and airway indices to antitussive therapy was studied in a randomized double-blind trial in which 60 adults without bronchopulmonary disorders, but suffering from common colds, were given oral doses of five drug formulations placebo during their initial 48 h of symptoms. Thoracic gas volume (V_tg), nasal (R_n), lower (R_a), total ([R_n + R_a]) and specific (sR_a) airway resistances were determined plethysmographically; forced vital capacity (FVC), forced expiratory volume for the first second (FEV_1.0) and maximal mid-expiratory flow rate (MMEFR) were recorded spirometrically. Cough pressure at peak flow furnished an index of cough (CI). The measurements were made at baseline and for 4 h after drug; medication was continued for two additional doses and the indices determined again the following morning. Abnormal control means were noted for R_n and [R_n + R_a] (90.8%), cough resistance (83.3%), MMEFR (58.3%), R_a and sR_a (30.0%), but less often for FEV_1.0, V_tg and FVC (6.6, 5.1 and 0.0%, respectively). Nasal and total airways flow resistance means were as sensitive to active therapy and in discriminating the relative worth of medication as direct CI values, R_a and sR_a were less reliable, and the three spirometric functions were the least responsive. This ranking was consistent with the common central airways location of subepithelial receptors responsible for cough and the associated reflex bronchoconstriction. The greatest changes in cough resistance followed treatment with the most significant activity in the nasal, as well as the lower tract, component of total airway resistance.

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Section: Discussionmentioning

confidence: 99%

Respiratory and Cough Mechanics in Antitussive Trials

Cohen¹

1975

Respiration

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The Evaluation of Antitussive Agents

Cited by 1 publication

References 6 publications

Respiratory and Cough Mechanics in Antitussive Trials

Respiratory and Cough Mechanics in Antitussive Trials

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