The Evaluation of Benzodiazepine-induced Dysphagia Using High-resolution Manometry

Abstract

We evaluated the pathophysiology of dysphagia considered to be induced by benzodiazepine using highresolution manometry (HRM). A 53-year-old man with Parkinson disease had had dysphagia for over 3 months. He had been taking several benzodiazepines for more than four years. Two weeks after discontinuation of the benzodiazepines, HRM revealed increased pharyngeal contractility and residual pressure at the upper esophageal sphincter. A video-fluoroscopic swallowing study showed improved pharyngeal bolus passage. Benzodiazepine-induced dysphagia may be due to the muscle relaxant effects on the swallowing muscles and attenuation of the barrier function which prevents reflux from the esophagus into the pharynx.

Drug induced Parkinson’s: A comprehensive review of the issues and measures required to tackle the same

“…PatientIn this reported case, a 53-year-old man with Parkinson's disease experienced dysphagia for over 3 months, which was attributed to the long-term use of benzodiazepines; however, discontinuation of these medications resulted in improved dysphagia and enhanced pharyngeal bolus passage, highlighting the potential for recovery after discontinuing benzodiazepines and the role of these drugs in inducing dysphagia [39].…”