The evaluation of dripping behaviors during the manufacturing process based on image processing method: Application to the Ginkgo biloba leaf dripping pills

Wang, Xiaoping; Qu, Haibin

doi:10.1016/j.eswa.2021.115897

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…Therefore, the laser detection system is suitable for on‐line analysis and monitoring the dripping process of dripping pills. Moreover, the developed laser detection system had advantages over the image processing method [18], showed higher efficiency, and required less storage space.…”

Section: Resultsmentioning

confidence: 99%

“…In industrial production lines, operators usually sample droplets from a drop head every ten minutes or half an hour and weigh them using an electronic balance to monitor the dripping process. However, there are few studies of sensor technology or PAT tools that can inspect the quality of the dripping pills [17], monitor and control the dripping process [18]. Therefore, more efficient detection systems should be constructed based on sensor technology or PAT tools to better understand, analyze, monitor, and control the preparation process in dripping pills manufacturing.…”

Section: Introductionmentioning

confidence: 99%

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Real‐time droplet size analysis using laser micrometer as a process analytical technology tool for continuous dripping process

Wang

Tian

Zhang

et al. 2022

Engineering in Life Sciences

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Process analysis and monitoring during the manufacturing of the dripping pills are essential. However, research on developing sensor-based technology or process analytical technology (PAT) tools to analyze and monitor the dripping process is minimal. The purpose of this work is to develop a fast and non-destructive laser detection system for quantitative visualization of droplets, which involves detecting the size of the droplet and calculating the weight of the dripping pills during the dripping process. Several factors influencing the detection performance of the detection system and the detection system capability for quantitation of the pill weight were explored. The laser detection system accurately detects the weight of the dripping pills with the coefficients of determination (R 2 ) higher than 0.99. It was also robust concerning the variation in critical process parameters and critical material attributes. Furthermore, the laser detection system was successfully applied to the production line of Ginkgo biloba leaf dripping pills to monitor the dripping pills weight. The proposed laser detection system can analyze and monitor the dripping process in dripping pill manufacturing with stable performance, high accuracy, and high efficiency.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Real‐time droplet size analysis using laser micrometer as a process analytical technology tool for continuous dripping process

Wang

Tian

Zhang

et al. 2022

Engineering in Life Sciences

Self Cite

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Investigation of Rheological Properties of Molten Materials for Dripping Pills Based on Imaging Monitoring

Tian,

Chen,

Zhao

et al. 2024

Phytochemical Analysis

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IntroductionRheological properties, as critical material attributes (CMAs) of solid dispersion drugs such as dripping pills, affect the melting, dispersion, and solidification. Therefore, characterization and assessments of rheological properties in the pharmaceutical process are important in enhancing drug stability and bioavailability.ObjectivesThe study aimed to develop a method for analyzing the rheology of molten materials, assessing their consistency and how rheological properties affect the dripping process and pills quality.Materials and MethodsThe rheological behavior of molten materials composed of Ginkgo biloba leaf extract (GBE) and polyethylene glycol (PEG) 4000 was characterized. Batch consistency of molten materials was evaluated. Image monitoring technology was utilized to capture and process images of the droplet formation process. We established the relationship between the rheological properties of molten materials and various attributes.ResultsThe quality consistency of molten materials was evaluated, with 12 batches showing similarity above 0.8. The MLR models showed strong correlations (R2 > 0.80) between rheological properties and evaluation attributes. The rheological properties, including consistency coefficient, flow index, and viscosity at 80°C, were identified as critical rheological properties of the molten materials. Rheological property differences of molten materials have an impact on the morphology of droplet and quality performance.ConclusionA rheological method was established, enabling quality consistency evaluation of molten materials in dripping pills. This study revealed the influence of rheological properties on droplet formation process and dripping pills quality, providing a reference for researches on material attributes control of other traditional Chinese medicine dripping pills.

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Image processing-based online analysis and feedback control system for droplet dripping process

Chen,

Tian,

Zhang

et al. 2024

International Journal of Pharmaceutics

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The evaluation of dripping behaviors during the manufacturing process based on image processing method: Application to the Ginkgo biloba leaf dripping pills

Cited by 4 publications

References 45 publications

Real‐time droplet size analysis using laser micrometer as a process analytical technology tool for continuous dripping process

Real‐time droplet size analysis using laser micrometer as a process analytical technology tool for continuous dripping process

Investigation of Rheological Properties of Molten Materials for Dripping Pills Based on Imaging Monitoring

Image processing-based online analysis and feedback control system for droplet dripping process

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