The evaluation of efficacy and tolerability of Hylan G-F 20 in bilateral thumb base osteoarthritis: 6 months follow-up

Abstract

The aims of this randomized controlled trial were to evaluate the efficacy of intra-articular Hylan G-F 20 on the pain, pinch strength, and functional status in patients with thumb base osteoarthritis (OA). Sixty-six hands of 33 female patients (mean age, 62.6 +/- 6.4 years) with bilateral clinical and radiological thumb base OA were included into this study. Hands of the same patient were divided to Hylan G-F 20 and saline-injection groups. VAS pain 100 mm, pinch strength (key, tripod and pulp to pulp pinch) and functionality (Dreiser functional index) were assessed at baseline, at sixth and 24th weeks. Statistically significant improvements were detected in function (p = 0.001), VAS pain (p = 0.002), and pinch strength (p = 0.004) at the 24th week in the Hylan G-F 20 group. However, only VAS pain scores decreased temporarily in control hands at the 6th week (p = 0.02). Although short-term placebo analgesic effect could not be ignored, intra-articular hylan was effective on pain, pinch strength, and function at the 24th week.

Intra-articular injections in thumb osteoarthritis: A systematic review and meta-analysis of randomized controlled trials

“…1). For 3 studies, the results described in the articles did not allow meta-analysis, but the studies are reported descriptively here (Table 1) [18][19][20]. After adding 1 report from congress abstracts, 9 reports were included ( Table 1).…”

“…Mandl's study [22] showed efficacy of hyaluronic acid (62 patients) on functional capacity and of placebo (62 patients) on pain at week 24 ( Table 2). Figen Ayhan's study [18] (not included in the metaanalysis) compared with baseline but not together 2 groups of 29 patients. It indicated lower pain and improvement of functional capacity at week 24 after one injection of hyaluronic acid.…”

“…[18][19][20][21][22][23][24][25][26]. Thus this meta-analysis included 428 patients; 168 (39.2%) treated by hyaluronic acid injections, 166 (38.8%) by corticosteroids injections and 94 (22.0%) by placebo.…”

Hand Osteoarthritis: An Update on Therapy

“…Significant improvements were detected in function, visual analog scale (VAS) pain, and pinch strength at 24 weeks in the Hylan G-F 20 group. 38 The placebo effect might partly explain the above results. To investigate that, as well as compare its effect with that of a corticosteroid injection, a prospective, double-blind RCT was conducted.…”

The 2014 guidelines for the management of osteoarthritis: Place of hyaluronic acid preparations

“…С 2006 г. в европей-ских странах одобрено введение препарата в плечо и голе-ностопный сустав. Есть данные о результатах введения ги-лана G-F 20 в височно-нижнечелюстной сустав [62], в пяст-но-запястный сустав большого пальца [63], в пястно-фалан-говые суставы [64]. В целом лечение гиланом G-F 20 хоро-шо переносится при введении в любой сустав, развития си-стемных нежелательных реакций (НР) не отмечено.…”