The evaluation of involvement of angiotensin II, its receptors, and androgen receptor in endometrial cancer

Matysiak, Zuzanna Elżbieta; Ochędalski, Tomasz; Piastowska-Ciesielska, Agnieszka Wanda

doi:10.3109/09513590.2014.958991

Cited by 14 publications

(17 citation statements)

References 69 publications

(79 reference statements)

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“…EC cases diagnosed with non-endometrioid type II lesions also presented with significantly higher levels of adrenal precursors and androgens but not estrogens, suggesting an influence of the tumor on the adrenal secretion and on peripheral conversion of adrenal precursors to androgens with no subsequent impact on aromatization. This is in agreement with recent studies sustaining that androgens may play an etiological role in Type II EC, independent of their conversion to estrogens [41][42][43]. Furthermore, certain risk factors such as cigarette smoking and alcohol intake might influence cancer risk by altering adrenal precursors and androgen levels [44].…”

Section: Discussionsupporting

confidence: 92%

Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery

Audet-Delage

Grégoire

Caron

et al. 2018

The Journal of Steroid Biochemistry and Molecular Biology

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Endometrial cancer (EC) is the most common gynecologic malignancy prevailing after menopause. Defining steroid profiles may help predict the risk of recurrence after hysterectomy, which remains limited due to the lack of reliable markers. Adrenal precursors, androgens, parent estrogens and catechol estrogen metabolites were measured by mass spectrometry (MS) in preoperative serums and those collected one month after hysterectomy from 246 newly diagnosed postmenopausal EC cases. We also examined the associations between steroid hormones and EC status by including 110 healthy postmenopausal women. Steroid concentrations were analyzed in relation to clinicopathological features, recurrence and overall survival (OS). The mean follow-up time was 65.5 months and 26 patients experienced relapse after surgery for a recurrence incidence of 10.6% (6.4% Type I and 29.5% Type II). Recurrence and OS were related to a more aggressive disease but not linked to body mass index. Preoperative levels of estriol (E) and estrone-sulfate (E-S) were inversely associated with recurrence in a multivariate logistic regression analysis (Hazard ratios (HRs) of 0.31, P=0.039 and 3.01, P=0.024; respectively). All circulating steroids declined considerably after surgery almost reaching those of healthy women, except 4-methoxy-E (4MeO-E) for which postoperative levels increased by 35% and were associated to a 68% decreased risk of recurrence (HR=0.32, P=0.015). Women diagnosed with both histological types of EC present significantly higher levels of steroids, in support of their mitogenic effects. The estrogen precursor E-S, the anticancer metabolite 4MeO-E, and E that exert mixed antagonist and agonist estrogenic activities and immunological effects, are potential independent prognostic factors.

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Section: Discussionsupporting

confidence: 92%

Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery

Audet-Delage

Grégoire

Caron

et al. 2018

The Journal of Steroid Biochemistry and Molecular Biology

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“…It was further concluded that T/C polymorphism may not directly be associated with the PCOS. The association may rely on the polymorphism when there is increased level of testosterone and insulin resistance [39].…”

Section: Aromatase and Pcosmentioning

confidence: 99%

Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article

Ajmal

Khan

Shaikh

2019

European Journal of Obstetrics & Gynecology and Reproductiv

176

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Polycystic ovary syndrome (PCOS) is a heterogeneous condition which is related to an endocrine reproductive disorder of females. It affects females of 18–44 age. The persistent hormonal disbalance leads to the complexities such as numerous cysts, an irregular menstrual cycle that ultimately leads to infertility among females. Many candidate genes have been identified to be one of the causes of PCOS. Different studies have been carried out to find the genetic correlation of PCOS. It is essential to carry out such studies that identify the clear cause of PCOS and its genetic association and hormonal disbalance. This review has highlighted different genes and their correlation with PCOS that leads to hormonal disbalance. Yet not in-depth but an attempt to study the genetic predisposition of PCOS.

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“…Accumulating evidence suggests that circulating ANGPTL8 is elevated in diabetes [ 73 – 85 , 104 ]. Diabetes is often associated with diabetic dyslipidaemia, characterized by hypertriglyceridaemia, lower HDL-C and postprandial lipaemia [ 105 ].…”

Section: Perspectivementioning

confidence: 99%

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking

2016

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Lipoprotein lipase (LPL) is a rate-limiting enzyme for hydrolysing circulating triglycerides (TG) into free fatty acids that are taken up by peripheral tissues. Postprandial LPL activity rises in white adipose tissue (WAT), but declines in the heart and skeletal muscle, thereby directing circulating TG to WAT for storage; the reverse is true during fasting. However, the mechanism for the tissue-specific regulation of LPL activity during the fed–fast cycle has been elusive. Recent identification of lipasin/angiopoietin-like 8 (Angptl8), a feeding-induced hepatokine, together with Angptl3 and Angptl4, provides intriguing, yet puzzling, insights, because all the three Angptl members are LPL inhibitors, and the deficiency (overexpression) of any one causes hypotriglyceridaemia (hypertriglyceridaemia). Then, why does nature need all of the three? Our recent data that Angptl8 negatively regulates LPL activity specifically in cardiac and skeletal muscles suggest an Angptl3-4-8 model: feeding induces Angptl8, activating the Angptl8–Angptl3 pathway, which inhibits LPL in cardiac and skeletal muscles, thereby making circulating TG available for uptake by WAT, in which LPL activity is elevated owing to diminished Angptl4; the reverse is true during fasting, which suppresses Angptl8 but induces Angptl4, thereby directing TG to muscles. The model suggests a general framework for how TG trafficking is regulated.

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The evaluation of involvement of angiotensin II, its receptors, and androgen receptor in endometrial cancer

Cited by 14 publications

References 69 publications

Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery

Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery

Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking

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