The evaluation of Paclitaxel effects on the Caco-2 cell line of colon cancer patients

Abstract

Background: Colon cancer is considered a malignant neoplasm. Paclitaxel is anti-carcinogenic chemotherapy that stimulates the apoptosis of cancer cells.Objective: This study aims to know the effect of paclitaxel on the level of Reactive oxygen species (ROS) on Caco-2 of colon cancer cells by the High-content screening technique.Methods: Normal and cancerous human colon cells (Caco-2cell lines) were cultured, then treated with paclitaxel at two different quantitative doses (100 µg/ml) and (200 µg/ml) for 1-7 days. The examination was carried out at the