The evaluation of peri‐implant sulcus fluid osteocalcin, osteopontin, and osteonectin levels in peri‐implant diseases

Cakal, Oya Turkoglu; Efeoğlu, Candan; Bozkurt, Emir

doi:10.1002/jper.17-0475

Cited by 13 publications

(13 citation statements)

References 25 publications

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“…Osteocalcin, osteopontin and osteonectin proteins are related to bone remodeling. There were no significant differences in PICF osteocalcin, osteopontin and osteonectin total amounts between healthy controls, peri-implant mucositis and peri-implantitis groups in one recent study [46].…”

Section: Bone Loss Markersmentioning

confidence: 87%

Peri-Implantitis Diagnosis and Prognosis Using Biomarkers in Peri-Implant Crevicular Fluid: A Narrative Review

2019

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Dental implant diseases, peri-implantitis (PI) and peri-implant mucositis (PIM), have shown wide prevalence in recent studies. Despite the prevalence, diagnosing peri-implant disease (PID) remains challenging as common diagnostic methods of periodontal probing and radiographs may be inaccurate. These methods only document pre-existing destruction rather than current disease activity. Furthermore, there is no current model to predict the progression of PID. Though a predictive model is lacking, biomarkers may offer some potential. Biomarkers are commonly used in medicine to objectively determine disease state, or responses to a therapeutic intervention. Gingival crevicular fluid (GCF) biomarkers have moderate diagnostic validity in periodontitis. Biomarkers in peri-implant crevicular fluid (PICF) also show promising results in regard to their diagnostic and prognostic value. The aim of this review is to summarize the current knowledge of PICF biomarkers in the diagnosis of PID and evaluate their validity to predict disease progression. This review found that PICF studies utilize different methods of sampling and interpretation with varying validity (sensitivity and specificity). A number of promising diagnostic techniques were identified. Commercially available chair-side tests for MMP-8 to diagnose periodontal disease and PID activity are now available. Future directions include proteomics and metabolomics for accurate, site-specific diagnosis and prediction of PID progression. Although more research is needed, this review concludes that the assessment of proinflammatory cytokines (IL-1β, TNFα, MMP-8) in the PICF may be of value to diagnose PI and PIM but current research remains insufficient to indicate whether biomarkers predict peri-implant disease progression.

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Section: Bone Loss Markersmentioning

confidence: 87%

Peri-Implantitis Diagnosis and Prognosis Using Biomarkers in Peri-Implant Crevicular Fluid: A Narrative Review

2019

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“…Since the number of implants for each group and the number of implants for each person were unequal, the study design was unbalanced. Accordingly, we included random person effect and fixed effect for group in the model when comparing pocket depth, PISF volume, and PISF LL-37 and proteinase levels between two groups, and this model was analyzed by using SAS 9.3 4 . Group, jaw, and interaction effect between group and jaw were also evaluated for PISF LL-37 and proteinase 3 levels.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 78 samples (44 samples with peri-implantitis and 34 samples without peri-implantitis) were provided from 16 patients. PISF sampling was performed at interproximal surfaces of the implants as described before [4].…”

Section: Non-peri-implantitis Groupmentioning

confidence: 99%

“…Acipinar et al has demonstrated that FGF-23 and vitamin D seem to affect peri-implant bone health [7]. Previously, it was shown that peri-implantitis did not give rise to an increase in osteocalcin, osteopontin, and osteonectin levels in PISF [4]. Hence, studies investigating the biomarkers that reflect the changes during peri-implant inflammation continue.…”

Section: Introductionmentioning

confidence: 99%

“…Peri-implant sulcus fluid (PISF) is similar to gingival crevicular fluid as it reflects the inflammatory response [ 2 , 3 ]. It has been stated that the exudate leaking from the peri-implant tissue into the peri-implant sulcus increases during the inflammatory process [ 4 ]. Up to date, various cytokines in peri-implant sulcus fluid (PISF) have been investigated in peri-implant disease [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?

2020

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Background: Inactive human cathelicidin antimicrobial peptide is present in neutrophils, and proteinase 3 activates this peptide by producing active LL-37 peptide. LL-37 acts as a defensive peptide in the oral tissues. In the present study, the aim was to evaluate LL-37 and proteinase 3 levels in peri-implant sulcus fluid (PISF) in implants with and without peri-implantitis. Methods: Patients who simultaneously had dental implants with peri-implantitis and without peri-implantitis were included in the study. Forty-four samples with peri-implantitis and 34 samples without peri-implantitis from 16 patients were obtained. Intraoral evaluations such as pocket depth, modified sulcus bleeding index, and modified plaque index were noted. Enzyme-linked immunosorbent assay was used for the evaluation of PISF LL-37 and proteinase 3 levels. Results: PISF volume was significantly increased in the implants with peri-implantitis than those without periimplantitis (p < 0.05). No difference was present between PISF LL-37 and proteinase 3 total amounts between the implants with and without peri-implantitis (p > 0.05). Pocket depths and PISF LL-37 and proteinase 3 levels were not correlated in the groups (p > 0.05). Conclusions: PISF volume might be increased in response to peri-implant bone destruction. However, peri-implant tissue destruction caused by peri-implantitis does not seem to affect PISF LL-37 and proteinase 3 levels.

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Biomarkers for Implant Dentistry Studies

McGowan,

Han,

Ivanovski

2023

Surgical Research in Implant Dentistry

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The evaluation of peri‐implant sulcus fluid osteocalcin, osteopontin, and osteonectin levels in peri‐implant diseases

Abstract: Soft tissue inflammation around dental implants does not cause a change in osteocalcin, osteopontin, and osteonectin levels in PISF. Also, peri-implantitis does not seem to give rise to an increase in PISF levels of osteocalcin, osteopontin, and osteonectin.

Cited by 13 publications

References 25 publications

Peri-Implantitis Diagnosis and Prognosis Using Biomarkers in Peri-Implant Crevicular Fluid: A Narrative Review

Peri-Implantitis Diagnosis and Prognosis Using Biomarkers in Peri-Implant Crevicular Fluid: A Narrative Review

Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?

Biomarkers for Implant Dentistry Studies

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