The evaluation of psychiatric drug therapy on oral lichen planus patients with psychiatric disorders

Abstract

http://www.medicinaoral.com/medoralfree01/v15i2/medoralv15i2p322.pdf AbstractObjectives: Current treatments of oral lichen planus are palliative, not curative. Because psychiatric disorders significantly influence the development and severity of oral lichen planus, the use of psychiatric drug therapy may be an adjunct in treatment. The purpose of this study was to determine the efficacy of drug therapy of psychiatric disorders in oral lichen planus. Study design: Our controlled clinical study consisted of forty-six patients with oral lichen planus and psychiatric disorders who were randomly divided into two groups. Both groups were given topical corticosteroids and the study group received additional psychiatric drug therapy. Patients were monitored for a period of 6 months. Response to treatment was evaluated in each group and was compared with the other group using Mann-Whitney tests. We evaluated the correlation between psychiatric disorders and the recovery of oral lesions using Spearman's correlation coefficient analysis. Results: Decrease in the size of the lesions was significantly greater in the study group after six months, but this difference was not significant in relationship to the pain experienced and the kind of lesion. Spearman's correlation coefficient analysis demonstrated that, in the sixth month, there was a significant and direct relationship between recovery from the psychiatric disorders and response to treatment of OLP lesions, particularly as it pertained to the kind of lesion. Conclusion: The present study indicates that the combination of psychiatric drug therapy and routine treatment methods were effective in reducing the size of the lesions, but did not have any significant effect on the symptoms.

Prevalence of oral mucosal disorders in institutionalized and non-institutionalized psychiatric patients: a study from AVBR Hospital in central India

“…Hence, on the basis of the available literature, the reasons for increased prevalence of BMS and OLP in psychiatric patients may be multiple and involve the interaction of biological and psychological systems. Thus, Delavarian et al (20) suggested the use of a combination of psychotherapy and conventional treatment in OLP.…”

Psychiatric Comorbidity and Pharmacotherapy in Patients with Oral Lichen Planus

“…Different studies have been done for the evaluation of the relationship OLP and psychiatric disorders. These studies used various psychiatric questionnaires, but any treatment intervention has not been used but in our study, after diagnosis of psychiatric disorders by psychiatric interview, we treated these disorders with psychiatric pharmacotherapy (Delavarian 2010). Among different studies, some found a positive correlation between OLP and psychiatric disorders; however other studies did not establish such a relationship.…”

“…In another study, combination of amitriptyline, ketokonazole, and clobetasole in mouthwash form was useful in OLP patients (Javadzadeh 2008). For the first time, in one study, we evaluated the effects of concurrent routine treatment of OLP lesions with topical corticosteroid and psychiatric therapy of patients with psychiatric disorders (Delavarian 2010) .…”

“…The patients filled out informed written consent forms. The subjects having the inclusion criteria were chosen for the study (Delavarian 2010). Inclusion criteria include: 1. patients with oral lichen planus (all forms) with or without skin involvement; 2. affliction with psychiatric disorders.…”

“…The patients in the case group were evaluated for possible side effects of the medication(s) 2 weeks after the initiation of the study and afterwards were monthly examined by the psychologist, too. Treatment of patients continued until remission of signs and symptoms (Delavarian 2010). The recovery rate (response to treatment) in each patient was evaluated according to Tables 1 and 2, based on the percentage of the area involved, form of the lesion and the severity of the pain.…”