The evaluation of retinal and choroidal structural changes by optical coherence tomography in patients with chronic obstructive pulmonary disease

Gök, Mustafa; Özer, Murat Atabey; Özen, Serkan; Yıldırım, Berna Botan

doi:10.1080/02713683.2017.1373824

Cited by 27 publications

(41 citation statements)

References 31 publications

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“…This is in line with findings from the study of Gok et al. (), in which no significant difference was found in choroidal thickness of patients with mild to very severe COPD compared to matched controls. They also found no relationship between choroidal thickness and COPD severity (Gok et al.…”

Section: Methodssupporting

confidence: 93%

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Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients

Vaes

Spruit

Theunis

et al. 2018

Acta Ophthalmologica

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Chronic obstructive pulmonary disease (COPD) is a complex disease with many patients suffering from cardiovascular comorbidity. However, cardiovascular diseases remain often undiagnosed in COPD. Assessment of the retinal microvasculature can provide value in cardiovascular profiling of these patients. Retinal microvascular assessment carried out via a noninvasive eye exam represents an easy to use tool when examining patients with COPD. The purpose of this review was to provide an overview of studies assessing structural and functional changes in the retinal microvasculature of patients with COPD. Findings demonstrated that structural and functional microvascular changes were more common and severe in COPD patients as compared to non-COPD controls, although few retinal investigations have been performed in patients with COPD. As cardiovascular comorbidities are highly prevalent in COPD, we advocate more research to investigate the value of an eye exam for microvascular phenotyping of COPD patients.

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Section: Methodssupporting

confidence: 93%

“…They also found no relationship between choroidal thickness and COPD severity (Gok et al. ). Ugurlu and coworkers reported no significant difference in choroid thickness between a group of male COPD patients and male controls (Ugurlu et al.…”

Section: Methodsmentioning

confidence: 98%

Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients

Vaes

Spruit

Theunis

et al. 2018

Acta Ophthalmologica

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show abstract

“…Ozcimen et al and Gok et al found the mean RNFL thickness in patients with COPD to be significantly lower . Ugurlu et al also detected lower RNFL thickness in all segments in COPD patients but a significant thinning was only present in the inferior segment .…”

Section: Discussionmentioning

confidence: 90%

“…EDI mode, which is a newly defined method in OCT uses longer wavelength to investigate the choroidal tissues can detect the thickness of choroid tissue peripapillary or subfoveally . In the study by Gok et al; macular choroid thickness values in all COPD stages were reported to be lower than in the control group at all locations, but no statistically significant difference was present . Ugurlu et al reported no statistically significant difference in terms of SFCT between COPD patients and the control group .…”

Section: Discussionmentioning

confidence: 98%

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Correlatıon of neutrophyle/lymphocyte ratio and pulmonary parameters with optic coherence tomography findings in stable chronic obstructive pulmonary disease

Özer

Ogan

2020

Clinical Respiratory J

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Introduction To examine the correlation of pulmonary functions and neutrophyle/lymphocyte ratio (NLR) with optic coherence tomography findings in stable chronic obstructive pulmonary disease (COPD). Methods Fifty‐five COPD (110 eyes) and 48 control cases (96 eyes) were enrolled. COPD patients were grouped as Group 1 (mild‐moderate) and Group 2 (severe) according to GOLD classification. Subfoveal choroidal thickness (SFCT), ganglion cell‐inner plexiform layer (GCIP) and retinal nerve fiber layer (RNFL) analysis by SD‐OCT were performed in follow up. NLR was calculated by blood cell count. Results Inferior RNFL and average GCIP of COPD were lower than control during the initial and sixth month examination (P = .002, P < .001, respectively). Average RNFL and SFCT were lower in COPD patients in sixth month examination (P = .020, P = .015, respectively). Average, temporal, inferior, nasal RNFL and SFCT in sixth month examination were significantly lower in severe COPD (P < .05 for all), but average GCIP were similar (P = .015). Disease duration, Modified Medical Research Council (mMRC) and attacks/year showed significant negative correlations, whereas forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC) showed significant positive correlations with OCT values. NLR was significantly higher in COPD cases compared to control (P < .001) and had a negative correlation with GCIP values. Conclusion Chronic obstructive pulmonary disease severity is shown to have a negative effect on OCT measurements. SD‐OCT can reflect severity of inflammation, and suggested to be used in follow up of COPD cases. NLR may have a role to predict the ganglion cell damage in COPD patients.

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Association of retinal microvascular density and complexity with incident coronary heart disease

Fu¹,

Yusufu²,

Wang³

et al. 2023

Atherosclerosis

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The evaluation of retinal and choroidal structural changes by optical coherence tomography in patients with chronic obstructive pulmonary disease

Abstract: The study results revealed significant average, nasal RNFL, global GCL+ loss, and a nonsignificant choroidal thinning in patients with COPD compared to healthy subjects. The eye seems to be one of the affected tissues during the natural course of the COPD.

Cited by 27 publications

References 31 publications

Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients

Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients

Correlatıon of neutrophyle/lymphocyte ratio and pulmonary parameters with optic coherence tomography findings in stable chronic obstructive pulmonary disease

Association of retinal microvascular density and complexity with incident coronary heart disease

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