The Evaluation of Retinal Nerve Fiber Layer Thickness in Patients with Obstructive Sleep Apnea Syndrome

Adam, Mehmet; Okka, Mehmet; Yosunkaya, Şebnem; Bozkurt, Banu; Kerimoğlu, Hürkan; Turan, Meydan

doi:10.1155/2013/292158

Cited by 38 publications

(42 citation statements)

References 30 publications

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“…However, the results of studies using OCT to compare the RNFL thickness in patients with OSAHS and healthy controls have been inconsistent. Some studies reported a decrease in RNFL thickness in patients with OSAHS [7,9,10], whereas others found no statistically significant difference in RNFL thickness [11,12]. The aim of this study was to use a meta-analysis to evaluate changes in RNFL thickness in patients with OSAHS.…”

Section: Introductionmentioning

confidence: 99%

Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis

Mei

Feng

et al. 2016

Ophthalmic Res

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Purpose: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). Methods: The Cochrane Library, Medline, and Embase were screened using our key words. Results were carefully reviewed to ensure that the included studies met the inclusion/exclusion criteria, and the quality of the studies was assessed using the Newcastle-Ottawa Scale. All included studies categorized patients with OSAHS into 3 groups (mild, moderate, and severe), and measured average and 4-quadrant (temporal, superior, nasal, and inferior) RNFL thickness. All studies included a healthy control group. The weighted mean differences and 95% confidence intervals were calculated for the continuous outcomes. Results: Ten case-control studies were included in the meta-analysis, consisting of a total of 811 OSAHS group and 868 healthy eyes. A meta-analysis of the data showed that the average RNFL thicknesses in the mild, moderate, and severe OSAHS groups were significantly decreased compared to healthy controls. Additionally, RNFL thickness was significantly reduced in all but the temporal quadrant in the moderate and severe OSAHS groups when compared to healthy controls. Conclusions: On the basis of these results, we suggest that peripapillary RNFL thickness as measured by optical coherence tomography could be a useful tool to monitor and assess the severity of OSAHS in patients. Further studies are required in order to differentiate these RNFL changes from glaucomatous changes. This has not been properly examined in any of the studies we were able to identify.

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Section: Introductionmentioning

confidence: 99%

Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis

Mei

Feng

et al. 2016

Ophthalmic Res

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“…Degeneration after ischemia causes thinning of the RNFL. Adam, et al [33] reported that RNFL thickness was not different between the control and OSAS groups. Moghimi, et al [34] suggested that thinning of the RNFL has been associated with elevated intraocular pressure.…”

Section: Discussionmentioning

confidence: 95%

“…Thinning of RNFL may be related to ageing or may accompany ocular disorders. Histopathological studies reported RNFL thinning in various systemic diseases [33].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Retinal Nerve Fiber Layer and Optic Nerve Function in Patients with Obstructive Sleep Apnea Syndrome

Mualla¹,

Selma²,

Boynueğri³

et al. 2018

Int J Neurol Neurother

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Objective: To evaluate retinal nerve fiber layer thickness (RNLF) with optical coherence tomography (OCT) and optic nerve function with visual evoked potential (VEP) in patients with obstructive sleep apnea syndrome (OSAS). Methods:Fifty-one eyes of 30 newly diagnosed OSAS patients who received no treatment were included. The RNFL analysis with OCT and pattern VEP test (120',30',15',7' pattern size) was performed to all patients. Results:Of 30 patients, 20 were females and 10 were males. None of the patients were obese with a body mass index of (BMI) < 30 kg/m 2 . The mean Apnea Index of the patients was 42.5 ± 24.3. All patients had severe OSAS with an Apne Index of ≥ 30. Visual acuity was 20/20, intraocular pressure and optic disc were within natural limits in the all of the eyes included in the study. A statistically significant decrease (p < 0.05) was detected in the all parameters of p100 wave amplitude of VEP tests. Compared to the standard data of the healthy individuals at the same age, there was no significant difference in the p100 latency. Although there was thinning of the RNFL thickness, there was no statistically significant difference (p > 0.05). Conclusion:In patients with OSAS, ischemia during deep sleep causes optic nerve dysfunction which can be detected by electrophysiological test, even in asymptomatic patients. In this study, the importance of early diagnosis and treatment is emphasized, and particularly early treatment may halt the progression of the optic nerve dysfunction. For a better understanding of these diseases and ocular manifestations, further long-term studies are needed.

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“…43 OUAS'lu ve 40 kontrol hastasının MKK'ını değerlendirdikleri çalışmalarında gruplar arasında fark olmadığını belirtirken, Ekinci ve ark., 107 OUAS hastasını incelemiş ve uyku apnesinin MKK'de incelmeye neden olduğunu bildirmişler-dir. 9,18 Araştırmacılar, OUAS'daki kornea incelmesinin apne atakları sırasında oluşan hipoksi ve hiperkapniye bağlı olarak meydana gelebileceğini belirtmişlerdir.…”

Section: İstati̇sti̇ksel Anali̇zunclassified

Evaluation of Anterior Segment Parameters Using Corneal Topography in Obstructive Sleep Apnea Syndrome

Bayhan¹,

Muhafız²,

Bayhan³

et al. 2015

Turkiye Klinikleri J Ophthalmol

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Ö ÖZ ZE ET T A Am ma aç ç: : Obstrüktif uyku apne sendromu (OUAS) olan hastaların ön segment parametrelerinin kornea topografisi ile değerlendirilmesi ve sağlıklı bireyler ile karşılaştırılmasıdır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu prospektif çalışma kapsamında, 45 OUAS hastasının 45 gözü (OUAS grubu) ve 43 sağlıklı bireyin 43 gözü (kontrol grubu) değerlendirilmiştir. Tüm katılımcıların tanısı göğüs hastalıkları kliniği uyku laboratuvarında polisomnografi yapılarak konulmuştur. Hastaların rutin göz muayenelerinin ardından kornea topografisi ile ön segment ölçümleri yapılmıştır. Grupların merkezi kornea kalınlığı (MKK), dik ve düz keratometri değerleri, ön kamara derinliği (ÖKD), ön kamara hacmi (ÖKH), ön kamara açısı (ÖKA), kornea hacmi (KH), görülebilir horizontal iris çapı (GHİÇ) ve horizontal ön kamara çapı (HÖKÇ) verileri karşılaştırılmıştır. B Bu ul lg gu ul la ar r: : Gruplar arasında yaş ve cinsiyet açısından fark yok idi (p>0,05). Ortalama apne hipopne indeksi (AHI) değeri OUAS grubunda 26,78±23,56 iken, kontrol grubunda 3,00±1,64 idi (p<0,001). Gruplar arasında aksiyel uzunluk, göz içi basıncı, refraksiyon değeri ve görme keskinliği açısından anlamlı fark yok idi (p>0,05). MKK OUAS grubunda 529,28±27,63 µm, kontrol grubunda 522,17±34,17 µm idi (p=0,29). Düz ve dik keratometri değerleri OUAS grubunda sırasıyla 43,21±1,71 D ve 43,87±1,74 D, kontrol grubunda aynı sırayla 42,02±1,35 D ve 43,75±1,84 D olarak bulundu (p=0,23 ve p=0,74). Gruplar arasında ÖKA, ÖKD, ÖKH, KH, GHİÇ, HÖKÇ açısından istatistiksel anlamlı fark bulunmadı (p>0,05). S So on nu uç ç: : OUAS'ta ön segment parametrelerinin normal bireylerden farklılık göstermediği saptanmıştır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Uyku apnesi, tıkayıcı; anterior göz segmenti; kornea topografisi A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To evaluate the anterior segment parameters of obstructive sleep apnea syndrome (OUAS) patients using corneal topography and to compare them with those of healthy individuals. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : 45 eyes of 45 OUAS patients (OUAS group) and 43 eyes of 43 healthy individuals (control group) were evaluated in this prospective study. Diagnostic polysomnography was performed to all subjects in department of chest disease. After routine ophthalmological examination, anterior segment assesment using corneal topography was performed to the control and OUAS groups. Central corneal thickness (CCT), steep and flat keratometry, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), corneal volume (CV), horizontal visible iris diameter (HVID) and horizontal anterior chamber diameter (HACD) of groups were compared. R Re es su ul lt ts s: : There was no difference in age and sex between the groups (p>0.05). Mean apnea hypopnea index (AHI) value was 26.78±23.56 in the OUAS group and 3.00±1.64 in the control group (p<0,001). There was no difference in axial length, intraocular pressure, refraction, visual acui...

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The Evaluation of Retinal Nerve Fiber Layer Thickness in Patients with Obstructive Sleep Apnea Syndrome

Cited by 38 publications

References 30 publications

Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis

Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis

Evaluation of Retinal Nerve Fiber Layer and Optic Nerve Function in Patients with Obstructive Sleep Apnea Syndrome

Evaluation of Anterior Segment Parameters Using Corneal Topography in Obstructive Sleep Apnea Syndrome

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