The evaluation of salivary oxidative stress in patients with familial Mediterranean fever and chronic periodontitis

Dinç, Gözde; Fentoğlu, Özlem; Doğru, Atalay; İlhan, İlter; Kırzıoğlu, Fatma Yeşim; Orhan, Hikmet

doi:10.1002/jper.17-0638

Cited by 6 publications

(5 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, the MEFV mediated activation of inflammatory pathways leads to an increase in serum acute phase reactants, resulting in periodontal disease. These mechanisms have also been supported by studies reporting higher clinical periodontal indices in patients with FMF 28,41 …”

Section: Discussionmentioning

confidence: 71%

Plasminogen gene polymorphisms [c.924C>T and IVS 8+14 G>A] in periodontitis and familial Mediterranean fever: A case‐control study

Fentoğlu

Tülüceoğlu

Orhan

2021

J of Periodontal Research

Self Cite

View full text Add to dashboard Cite

Background and objective The plasminogen (PLG) activation system plays an essential role in severe inflammation based diseases such as periodontitis, destructive membranous periodontal disease (ligneous periodontitis), familial Mediterranean fever (FMF), and amyloidosis. We have aimed to evaluate variations in PLG and the associations between PLG and MEFV genotypes in patients with FMF/ FMF‐related secondary amyloidosis and periodontitis. Material and methods A total of 247 individuals who were either diagnosed with FMF or systemically healthy were recruited to this human observational study with a cross‐sectional design. All individuals were also diagnosed with periodontitis or periodontally healthy. Blood samples were obtained from patients with FMF and systemically healthy controls. Clinical periodontal indicators were recorded. All polymorphisms located in exons 6 and 8 of PLG and mutations located on exons 2 and 10 of the MEFV gene were analyzed by DNA Sanger Sequencing. Genotypes and allele frequencies of PLG and MEFV were detected and tested by the Hardy‐Weinberg equilibrium. Serum levels of amyloid A (SAA), high‐sensitive C‐reactive protein (hs‐CRP), PLG, and salivary PLG levels were determined by using enzyme‐linked immunosorbent assay (ELISA). Results Two polymorphisms were identified in PLG: G to A polymorphism on the 14th nucleotide of intron 8 and C to T polymorphism on the 924th nucleotide of the coding region (IVS 8+14 G>A and c.924C>T, respectively). In IVS 8+14 G>A polymorphisms, wild‐type genotype: GG, heterozygote genotype: GA and homozygote genotype: AA. In c.924C>T polymorphism, wild‐type genotype: CC, heterozygote genotype: CT and homozygote genotype: TT. The frequency of the heterozygous polymorphisms of PLG was significantly increased (17.6%) in FMF patients with periodontitis (p = .027). A large proportion of the test group that was heterozygous for MEFV‐R202Q also had heterozygous PLG polymorphisms. Remarkable exacerbation in periodontal parameters was observed in patients with FMF and amyloidosis. SAA and hs‐CRP levels were significantly correlated with salivary PLG levels in patients with periodontitis and heterozygous PLG. Conclusions The current study describes IVS 8+14 G>A (rs2295368) and c.924C>T (rs1380916375) polymorphisms for the first time in the periodontal literature, which might play an important role in the pathogenesis of periodontitis, FMF, or amyloidosis. The elucidation of PLG polymorphisms is beneficial from a public health perspective by increasing the quality of life in these patients and reducing the mortality and morbidity associated with inflammatory diseases such as periodontal disease, FMF, and FMF‐related amyloidosis.

show abstract

Section: Discussionmentioning

confidence: 71%

Plasminogen gene polymorphisms [c.924C>T and IVS 8+14 G>A] in periodontitis and familial Mediterranean fever: A case‐control study

Fentoğlu

Tülüceoğlu

Orhan

2021

J of Periodontal Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…The absence of a correlation between the volumes of Peyronie’s plaque and the systemic OSI indices indicates that, to be truly meaningful, the study of OS must be performed by taking a sample directly from the site of the disease, as has already been carried out in other studies for other pathologies [ 49 , 50 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

“…Since OS plays an important role in PD, it is our opinion that, to obtain a more precise evaluation of OS in the disease under consideration, it is more appropriate to evaluate the oxidative state in both the penile corpora cavernosa and peripheral blood. There are already studies in the literature that have evaluated OSI in secretions (tears, saliva) taken from disease sites (ocular rosacea, periodontitis) [ 49 , 50 ].…”

Section: Introductionmentioning

confidence: 99%

Measurement of Oxidative Stress Index (OSI) in Penile Corpora Cavernosa and Peripheral Blood of Peyronie’s Disease Patients: A Report of 49 Cases

Paulis,

De Giorgio

et al. 2024

Metabolites

View full text Add to dashboard Cite

Peyronie’s disease (PD) is a chronic inflammatory disease affecting the penile albuginea. Oxidative stress (OS) is important for the development of the disease; therefore, it seemed interesting to us to directly measure OS at both the site of the disease and in peripheral blood. For a precise OS study, it is necessary to evaluate not only the single results of the total oxidant status (TOS) and total antioxidant status (TAS) but also their ratio: OS index (OSI) (arbitrary unit) = TOS/TAS × 100. This study included 49 PD patients examined and diagnosed in our Peyronie’s care center and a control group of 50 cases. We collected blood samples from both the penis and a vein in the upper extremity; we used d-ROMs and PAT-test (FRAS kit) for OS measurement. Pearson’s study found a statistical correlation between penile OSI values and PD plaque volumes: p-value = 0.002. No correlation was found between systemic OSI values and PD plaque volumes: p-value = 0.27. Penile OSI values were significantly reduced after the elimination of the PD plaque (p < 0.00001). The mean value of the penile OSI indices in the PD patients after plaque elimination corresponded to 0.090 ± 0.016 (p = 0.004). The comparison between the penile OSI values of the PD patients (with plaque elimination) and the control group revealed no statistically significant differences (p = 0.130). The absence of a correlation between Peyronie’s plaque volume and systemic OSI values indicates that it is preferable to carry out the OS study by taking a sample directly from the site of the disease. By carrying out a penile OSI study, it would be possible to obtain a precise plaque-volume-dependent oxidative marker. Even if the study did not demonstrate any correlation between OSI indices and anxious–depressive state, we detected a high prevalence of anxiety (81.6%) and depression (59.1%) in PD patients.

show abstract

“…Lipid peroxidation (LP) causes the formation of reactive hydroperoxides and their subsequent decomposition products, such as malondialdehyde (MDA). MDA has been shown to be an accurate biomarker for oxidative stress in patients with FMF [3,4,8,9]. Increased carotid artery intima media thickness (CIMT) [10,11] and impaired flow-mediated dilatation (FMD) have been reported in FMF patients [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory, Antioxidant, and Anti-Atherosclerotic Effects of Natural Supplements on Patients with FMF-Related AA Amyloidosis: A Non-Randomized 24-Week Open-Label Interventional Study

Romano

Garcia‐Bournissen

Piskin

et al. 2022

Life

View full text Add to dashboard Cite

We aimed to evaluate the effect of a combination of natural products on parameters related to inflammation, endothelial dysfunction, and oxidative stress in a cohort of familial Mediterranean fever (FMF) patients with Serum Amyloid A amyloidosis, in a non-randomized, 24-week open-label interventional study. Morinda citrifolia (anti-atherosclerotic-AAL), omega-3 (anti-inflammatory-AIC), and extract with Alaskan blueberry (antioxidant-AOL) were given to patients with FMF-related biopsy-proven AA amyloidosis. Patients were >18 years and had proteinuria (>3500 mg/day) but a normal estimated glomerular filtration rate (eGFR). Arterial flow-mediated dilatation (FMD), carotid intima media thickness (CIMT), and serum biomarkers asymmetric dimethylarginine (ADMA), high sensitivity C-reactive protein (hs-CRP), pentraxin (PTX3), malondialdehyde (MDA), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), and glutathione peroxidase (GSH-Px) were studied at baseline and after 24 weeks of treatment. A total of 67 FMF-related amyloidosis patients (52 male (77.6%); median age 36 years (range 21–66)) were enrolled. At the end of a 24-week treatment period with AAL, AIC, and AOL combination therapy, ADMA, MDA, PTX3, hsCRP, cholesterol, and proteinuria were significantly decreased compared to baseline, while CuZn-SOD, GSH-Px, and FMD levels were significantly increased. Changes in inflammatory markers PTX3, and hsCRP were negatively correlated with FMD change, and positively correlated with decreases in proteinuria, ADMA, MDA, cholesterol, and CIMT. Treatment with AAL, AIC and AOL combination for 24 weeks were significantly associated with reduction in inflammatory markers, improved endothelial functions, and oxidative state. Efficient control of these three mechanisms can have long term cardiovascular and renal benefits for patients with AA amyloidosis.

show abstract

The evaluation of salivary oxidative stress in patients with familial Mediterranean fever and chronic periodontitis

Cited by 6 publications

References 47 publications

Plasminogen gene polymorphisms [c.924C>T and IVS 8+14 G>A] in periodontitis and familial Mediterranean fever: A case‐control study

Plasminogen gene polymorphisms [c.924C>T and IVS 8+14 G>A] in periodontitis and familial Mediterranean fever: A case‐control study

Measurement of Oxidative Stress Index (OSI) in Penile Corpora Cavernosa and Peripheral Blood of Peyronie’s Disease Patients: A Report of 49 Cases

Anti-Inflammatory, Antioxidant, and Anti-Atherosclerotic Effects of Natural Supplements on Patients with FMF-Related AA Amyloidosis: A Non-Randomized 24-Week Open-Label Interventional Study

Contact Info

Product

Resources

About