The disruption era placed the digital industrial world as the paradigm and the new reference in the order of life that caused significant changes known as the Industrial Revolution 4.0. It also affects the laboratory as an integral part of science learning that contains teaching materials, media, facilities, strategies and assessment systems. To optimize the real laboratory as the development of hands-on science, it should be supported by a laboratory based on virtual instrument system (Lab-Vis) model to facilitate various practicums with interactive animation to emphasize the inquiry approach or syntax of "Observing", "Asking", "Testing", "Analyzing" and "Delivering". This study aims at producing the Lab-Vis model as the learning media of the Nature of Science (NOS). The Research and Development (R&D) method in this study employed the Five Phases of the Spiral Teaching Model adapted from the "Five Phases of Instructional Design" by Cennamo and Kalk, [1]. The syntax of this spiral model was done through 5 (five) development phases, i.e. (1) define, (2) design, (3) demonstrate, (4) develop, and (5) deliver. The results of this study were the laboratory model based on virtual instrument system as the learning media for NOS that was feasible based on the assessment results from the material and media experts. This developed product was also considered practical according to junior high school teachers and students who joined science courses.