The evaluation of the acute toxicity and long term safety of hydroalcoholic extract of Sapthaparna (Alstonia scholaris) in mice and rats

Baliga, Manjeshwar Shrinath; Jagetia, Ganesh Chandra; Ulloor, Jagadish; Baliga, Manjeshwar Poonam; Venkatesh, Ponemone; Reddy, R.L.; Rao, K. V. Nageswara; Baliga, Bantwal Shivanada; Devi, Sulochana; Raju, S; Veeresh, V.P.; Reddy, Tiyyagura Koti; Bairy, Laxminarayana Kurady

doi:10.1016/j.toxlet.2004.01.015

Cited by 62 publications

(36 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our work, we observed discrete biochemical and histological changes after the administration of dolabelladienotriol, showing that some injuries might occur and might not be completely reversible. In fact, others have shown that applications of plant extracts or their products can cause changes in the tissues of organs such as the liver, kidney and others (Baliga et al, 2004;Lima et al, 2009;Mariz et al, 2006;Mukinda & Syce, 2007;Omar et al, 1996;Rauber et al, 2006). The rationale for choosing acyclovir (de Miranda et al, 1981) as the control (50 mg/kg) was to compare dolabelladienotriol with a drug already used as an antiviral agent against HSV-1 in the clinical setting.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Garrido¹,

Teixeira²,

Teixeira³

et al. 2011

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Dolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples taken at three different times (Bs.0, Bs.1 and Bs.2) and optical microscopic examination of organs like liver, kidney, stomach and small intestine. Mice deaths were not observed at any dose during the ten day period. There were some changes in the biochemical analysis results for urea nitrogen (BUN) and alanine aminotransferase (ALT), but the changes were not significantly different from the reference levels of the animals before administration of the substance. Histological analyses of tissues were very similar for all animals. The alterations in liver and kidney tissues did not affect the animals´ behavior at any concentration, not even at 50 mg/kg, where the most significant changes in tissues were seen. This study indicates that dolabelladienotriol has low toxicity in administered dose range.

show abstract

Section: Resultsmentioning

confidence: 99%

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Garrido¹,

Teixeira²,

Teixeira³

et al. 2011

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…The renal function was assessed by measuring the concentrations of urea and plasma creatinine (Baliga et al, 2004;Tahraoui et al, 2010;Harizal et al, 2010;Atsamo et al, 2011). Concerning the biochemical data, all blood biochemical parameters examined in this study were in physiological limits as reported by Quinton (2003).…”

Section: Sub-chronic Oral Toxicity Of the Vegetable Oil Of Pistacia Lmentioning

confidence: 70%

Physicochemical Characteristics and Sub Chronic Oral Toxicity of <i>Pistacia lentiscus</i> L. Vegetable Oil in Rabbits

Maameri¹,

Djerrou²,

Habibatni³

et al. 2016

OnLine Journal of Biological Sciences

View full text Add to dashboard Cite

Pistacia lentiscus vegetable oil is a well known natural product in Algerian traditional medicine. It is widely used in the treatment of back pain, respiratory problems and skin burns. The aim of this study was the determination of some physicochemical parameters and the investigation of sub-chronic oral toxicity of this fatty oil in rabbits. The physico-chemical parameters obtained for this oil were similar to those reported for similar oils [density: 0.915, refractive index: 1.46; acid value (mg KOH/g): 8.4; saponification value (mg KOH/g): 187.5]. The sub-chronic toxicity test conducted in rabbits at different doses (0.5, 1 and 2 mL kg −1 ) for 28 days via oral route did not result in any signs of toxicity. The biochemicals results indicate that this oil maintain rates of ALT and AST in the physiological norms. A significant decrease in blood glucose was registered, but always within the physiological standards. Other experimental studies are required to accomplish the pharmacotoxicological profile of this vegetable oil which is in spreading use.

show abstract

“…22 A scholaris is used as a tonic, antiperiodic, anthelminthic, stimulant, carminative, stomachic, and expectorant. 23,24 The ripe fruits are used to treat insanity, which was earlier thought to be caused by epilepsy and syphilis. The most extensively used part of the plant is the bark, which is a component of many herbal formulations.…”

Section: Discussionmentioning

confidence: 99%

“…The bark extract of the powdered stem bark is a bitter tonic and febrifuge, useful for the treatment of malaria, diarrhea, and dysentery. 23 The bark decoction is also used to treat asthma, hypertension, lung cancer, and pneumonia. 24 It has been reported that A scholaris bark contains the alkaloids alstonidine, alstonin, alstovenine, chlorogenic acid, chlorogenine, ditain, ditaine, echicaoutchin, echicerin, echiretin, echitamine, echaitein, echitinin, echitin, porphyrine, porphyrosine, and reserpine.…”

Section: Discussionmentioning

confidence: 99%

Anticancer Activity of an Indian Medicinal Plant, Alstonia scholaris, on Skin Carcinogenesis in Mice

2009

View full text Add to dashboard Cite

Alstonia scholaris, commonly known as sapthaparna, has been used for centuries in Ayurvedic medicine for treatment of various disorders. The objective of this study was to investigate the possible chemopreventive and anti-oxidative properties of this medicinal plant on two-stage process of skin carcinogenesis induced by a single application of 7, 12-dimethyabenz(a)anthrecene (100 ìg/100 ìl acetone), and two weeks later, promoted by repeated application of croton oil (1% in acetone/thrice a week) till the end of the experiment (16 weeks) in Swiss albino mice. The tumor incidence, tumor yield, tumor burden and cumulative number of papillomas were found to be higher in the carcinogen treated control (without ASE treatment) as compared to experimental animals (ASE treated). Furthermore, a significant increase in reduced glutathione, superoxide dismutase and catalase but decrease in lipid peroxidation was measured in ASE administered experimental groups than the carcinogen treated control. The present study demonstrates the chemopreventive potential of Alstonia scholaris bark extract in DMBA-induced skin tumorigenesis in Swiss albino mice.

show abstract

The evaluation of the acute toxicity and long term safety of hydroalcoholic extract of Sapthaparna (Alstonia scholaris) in mice and rats

Cited by 62 publications

References 21 publications

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Physicochemical Characteristics and Sub Chronic Oral Toxicity of <i>Pistacia lentiscus</i> L. Vegetable Oil in Rabbits

Anticancer Activity of an Indian Medicinal Plant, Alstonia scholaris, on Skin Carcinogenesis in Mice

Contact Info

Product

Resources

About