The evaluation of the biomedical effectiveness of poly(amido)amine dendrimers generation 4.0 as a drug and as drug carriers: A systematic review and meta-analysis

Jędrych, Marian; Borowska, Katarzyna; Galus, Ryszard; Jodłowska‐Jędrych, Barbara

doi:10.1016/j.ijpharm.2013.12.033

Cited by 24 publications

(15 citation statements)

References 31 publications

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“…The PAMAM dendrimers used in this study are comprised of an ethylenediamine core and four amidoamine dendron arms, and terminated with amine groups, and therefore, bear positive charges [16]. For PEG-PAMAM, 10% terminal amine groups are replaced by PEG (MW 5000) [17], which not only confers the PEG-PAMAM higher biocompatibility and lower toxicity than PAMAM, but also leaves enough positive charges on the PEG-PAMAM to facilitate their binding to negatively charged lipid compartments of the PB-NLCs through static interaction [18].…”

Section: Introductionmentioning

confidence: 99%

G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol

Chen

et al. 2015

Journal of Controlled Release

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Section: Introductionmentioning

confidence: 99%

G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol

Chen

et al. 2015

Journal of Controlled Release

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“…We used two related biophysical techniques to study the binding behaviour of anionic PAMAM G4.5 and cationic PAMAM G5 to zwitterionic DPPC and anionic DPPG monolayers. To our knowledge, existing membrane studies of PAMAM dendrimers have been mainly focussing on cationic dendrimers [26,27,29] as due to their charge they have been proven good agents for drug [3,4] and gene delivery [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Poly (amidoamine) (PAMAM) dendrimers are monodispersed polymeric systems characterised by a well-defined molecular architecture [1,2]. In the context of polymer therapeutics, PAMAM dendrimers have been explored for multiple purposes: as drug/gene carriers [3,4,5] and as biologically active polymers per se. In particular, full generation PAMAM dendrimers have been investigated for use in gene delivery [6] as the positive charges conferred by the primary amino groups on the surface of the dendrimer make them ideal for complexing with negatively charged DNA [7,8].…”

Section: Introductionmentioning

confidence: 99%

Biophysical studies in polymer therapeutics: the interactions of anionic and cationic PAMAM dendrimers with lipid monolayers

Wilde

Green

Sanders

et al. 2017

Journal of Drug Targeting

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Understanding how polymers interact with biological membranes is important for the development of polymer-based therapeutics and wider biomedical applications. Here, biophysical methods (surface pressure measurements, external reflection FTIR) have been used to investigate the interaction between PAMAM dendrimers (Generation 5 or 4.5) and anionic (DPPG) or zwitterionic (DPPC) model membranes. We observed a concentration-dependent binding behaviour of both PAMAM species to both model membranes; however, equivalent levels of penetration into DPPC monolayers required approximately 10-fold higher dendrimer concentrations than for penetration into DPPG monolayers. Overall, the anionic PAMAM G4.5 showed a slightly better penetration ability which could be caused by repulsive forces towards the lipid layers. In comparison, increasing concentration of cationic PAMAM G5 leads to saturation of adsorption at the anionic lipid surface before penetration into the lipid layer likely driven by electrostatic attraction. Our studies also showed that physiologically relevant concentrations of sodium chloride (144 mM) decreased PAMAM penetration into DPPG monolayers but did not significantly affect the dendrimer-DPPC interaction. These results provide an insight into the mechanism of interaction between charged dendritic polymers with a lipid interface and show that the nature of such interactions are affected by lipid headgroup, dendrimer charge and solution salinity.

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“…Dendrimer were able to penetrate the skin through intercellular lipids and hair follicles. With iontophoresis, dendrimer was also found in localized skin regions (Jędrych, Borowska, Galus, & Jodłowska-Jędrych, 2014;Venuganti, Sahdev, Hildreth, Guan, & Perumal, 2011).…”

Section: Dendrimersmentioning

confidence: 99%

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

Damiani

Pacifico

Linder

et al. 2019

Dermatologic Therapy

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Nanodermatology is an emerging, multidisciplinary science, arising from the convergence of nanotechnology, pharmacology, physics/biophysics, chemistry/biochemistry, chemical engineering, material science, and clinical medicine. Nanodermatology deals with (a) skin biology, anatomy, and physiology at the nanoscale (“skin nanobiology”), (b) diagnosis performed by means of novel diagnostic devices, assisted by nanobiotechnologies (“nanodiagnosis”), and (c) treatment through innovative therapeutic agents, including phototherapy (“photonanotherapy”/“photonanodermatology”) and systemic/topical drug administration (“nanotherapy”) at the nanoscale, and drug delivery—such as transdermal or dermal drug delivery (TDDD/DDD)—enhanced and improved by nanostructures and nanodrugs (“nanodrug delivery”). Nanodermatology, as a super‐specialized branch of dermatology, is a quite recent specialty: the “Nanodermatology Society” founded by the eminent dermatologist Dr. Adnan Nasir, was established in 2010, with the aim of bringing together different stakeholders, including dermatologists, nanotechnology scientists, policy‐makers and regulators, as well as students and medical residents. Psoriasis has a prevalence of 2–3% worldwide and imposes a severe clinical and societal burden. Nanodermatology‐based solutions appear promising for the proper treatment and management of psoriasis, assisting and enhancing different steps of the process of health‐care delivery: from the diagnosis to the therapeutics, paving the way for a personalized approach, based on the specific dysregulated biomarkers.

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The evaluation of the biomedical effectiveness of poly(amido)amine dendrimers generation 4.0 as a drug and as drug carriers: A systematic review and meta-analysis

Cited by 24 publications

References 31 publications

G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol

G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol

Biophysical studies in polymer therapeutics: the interactions of anionic and cationic PAMAM dendrimers with lipid monolayers

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

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