The evaluation of the role of CCK in the opioid modulation of the motility of the gastrointestinal tract in sheep

Bf, Kania; Brikas, P.; Buéno, Lionel; Fioramonti, Jean; Zaremba-Rutkowska, M

doi:10.1046/j.1365-2885.1999.00190.x

Cited by 11 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further study showed that CCK antagonist L-364,718 could induce the premature phase 3 in ovine duodenum thus confirming indirectly the previous suggestion (Onaga et al, 1997). The opposite effect after central administration of CCK antagonist was obtained by Kania et al (1999). Thus, the aim of this study was to assess the precise effect of CCK-octapeptide (CCK-OP) on the MMC in the entire small intestine of conscious sheep.…”

Section: Introductionsupporting

confidence: 81%

The effect of cholecystokinin octapeptide upon the migrating myoelectric complex in the ovine small bowel

Romanski¹

2007

Acta vet. (Beogr.)

View full text Add to dashboard Cite

There is no evident and precise data regarding the effect of cholecystokinin octapeptide (CCK-OP) on the migrating myoelectric complex (MMC) in sheep. Thus, in five rams seven bipolar platinum electrodes were implanted in the abomasal antrum and entire small intestine. The strain gauge force transducer was also attached near the duodenal electrode in three of these animals. During the experiments the myoelectric and motor activity was continuously recorded in fasted and non-fasted sheep. During the recordings two normal consecutive phases 3 of the MMC were recorded. Then, slow injections of CCK-OP of 0.02; 0.2 and 2.0 _g/kg of body weight were given intravenously during phase 1, 2a or 2b of the MMC, identified in the duodenum, until next two consecutive phases 3 MMC were recorded. The moderate dose of CCK-OP administered during phase 2a in non-fasted animals shortened the MMC cycles significantly while the highest dose of the hormone increased the cycle duration and inhibited phase 3 MMC in the duodenum. No such effect was observed in the jejunum. However, duration of phase 3 in this region was decreased mostly by the highest dose of CCK-OP. It can be concluded that CCK inhibits the MMC in ovine small bowel and its effect in the duodenum is most pronounced

show abstract

Section: Introductionsupporting

confidence: 81%

The effect of cholecystokinin octapeptide upon the migrating myoelectric complex in the ovine small bowel

Romanski¹

2007

Acta vet. (Beogr.)

View full text Add to dashboard Cite

show abstract

“…The results obtained were nonsignificant in comparison with the results obtained after the intraduodenal balloon placed and no influencing on the interpretation of the results obtained. Mechanical duodenal distension by balloon 10 cm in length with 40 mL of warm water (DD40) provoked during and after 5 min total inhibition of spiking activity [30,32] or contraction of the rumen and duodenum during 8-12 min (p ≤ 0.01, Figure 2), approximately 85%. These effects, lasting 20 min after DD termination (average 47.3%) were statistically significant (p ≤ 0.05) in comparison to the control values (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…The analysis of mechanograms and calculations of results were performed similarly as in a case of electromyographic recording [32]. The number of the rumen motor activity was determined by the frequency on mechanograms, with 5 min intervals before and after the DD40.…”

Section: Mechanographymentioning

confidence: 99%

Voltage-Gated Calcium Channel Antagonists: Potential Analgesics for Jejunal Pains

Feliks¹,

Wrońska²

2017

Pain Relief - From Analgesics to Alternative Therapies

View full text Add to dashboard Cite

The significant role of voltage-gated calcium channel (VGCC) L-type antagonists used concomitantly with opioids in attenuation of clinical pain has been confirmed. The aim of this study is to evaluate the comparable effect of intracerebroventricularly (i.c.v.) administered diltiazem, nifedipine and/or verapamil -specific antagonists of VGCCsin the dose of 1.0 and 2.0 mg in toto on behavioral signs, clinical symptoms, rumen motor activity and biochemical (plasma cortisol and catecholamine-CA) parameters in sheep that have undergone experimental duodenal distension (DD) and to determine whether voltage-gated calcium channel inhibitors (VGCCIs) exert any anti-nociceptive effects under these conditions. The study was carried out using 24 mature, behind reproductive season crossbred ewes, each weighing 32-42 kg. DD was managed by inclusion and the distension of stretching balloon (having 40 mL of water 39°C temperature-DD40). After 5 min of DD40, the signs were observed: an important augmentation of behavioral nociceptive signs, particularly looking around, defecation, head movement, stretching, grinding, lying down, tachycardia, hyperventilation, inhibition of ruminal contractions (70% approximately, during 15 min) and an increase in plasma catecholamine concentration (over sevenfold increase of epinephrine (E): from 0.24 ± 0.12 in control to 2.98 ± 0.21 mM L −1 during 2 h following DD, 2-times norepinephrine (NE): from 1.29 ± 0.23 in control to 2.51 ± 0.30 mM L −1 and 124% increase of dopamine (DA): from 0.94 ± 0.02 in control to 2.10 ± 0.35 mM L −1 ). VGCCI infusion administered 10 min before duodenal distension diminished severity of jejunal nociceptive reactions, for instance, behavioral symptoms, cardiac acceleration, increase in the number of respiration, inhibition of the reticulum and rumen hypomotility, and effortlessly abolished the increasing presence of plasma cortisol and biogenic amines (CA) release. We suggest that the increase and insistence of visceral hyperalgesia stimulate the flow of Ca 2+ ion flow, provoking neurohormones/neuromediators liberatione and cytoplasmic membrane responsiveness modulation. This result confirmed analgesic effects of VGCCIs L-and/or R-type (nimodipine, lercanidipine, SNX-482) obtained by other authors and also suggests that these channels play a crucial role in the modulation of acute visceral hyperalgesia in sheep and may be a therapeutic target for new drugs.

show abstract

“…However, the morphine can stimulate motilin release, thus its action can be, at least in part, independent of the nervous system (Poitras et al., 1985). In sheep, CCK can interfere with the opioid modulation of the gastrointestinal motility, which suggests that CCK may exert its gastrointestinal motor effects mainly through the neural mechanisms (Kania et al., 1999). In monogastrics it is well known that the nervous system participates in the action of CCK on gastrointestinal motility (Grider, 1994).…”

Section: Discussionmentioning

confidence: 99%

Regional differences in the effects of various doses of cerulein upon the small‐intestinal migrating motor complex in fasted and non‐fasted sheep

Romanski¹

2006

Animal Physiology Nutrition

View full text Add to dashboard Cite

There are no precise data concerning the effect of cerulein on the small-intestinal migrating motor complex (MMC) in sheep. Thus, the effort was directed towards the elucidation of the role of cerulein, a cholecystokinin (CCK) amphibian analogue, in the regulation of MMC cycle in conscious fasted and non-fasted sheep in various regions of the small intestine. In six sheep, equipped with bipolar electrodes in the entire small intestine and with one duodenal strain gauge force transducer in four of these animals, the continuous myoelectric and motor activity recordings were performed. During control period, two normal consecutive MMC cycles were recorded in fasted and non-fasted animals and then cerulein was slowly injected at the dose 1 (during 30 s), 10 (during 30 s or 60 s) or 100 ng/kg (during 30 s, 60 s or 120 s) or infused at the dose 0.5 or 1.5 ng/kg/min during 60 min. After cerulein administration at least two consecutive MMC cycles were also recorded. It was found that cerulein in moderate and higher doses injected in both fasted and non-fasted animals, especially during phase 2a or 2b MMC, inhibited phase 3 in the duodenum in at least one-third of the experiments and significantly increased the MMC cycle duration. The application of 100 ng/kg of cerulein during 120 s in the course of phase 2b MMC prolonged cycle duration from 70 +/- 21 to 113 +/- 19 min (p < 0.05) or from 51 +/- 18 to 113 +/- 19 min (p < 0.01) in fasted and non-fasted sheep respectively. The first phase 3 MMC arriving after cerulein administration at the highest dose was usually abnormal in approximately 60% of the experiments. The second phase 3 observed following the hormone injection was abnormal much less frequently and to the lesser extent. Furthermore, both cerulein doses significantly shortened the duration of phase 3 MMC either in fasted (from approximately 5.5-6.5 cpm to 4-5 cpm) or in non-fasted sheep (from approximately 4.5-5.5 to 3-4.5 cpm). The effects of cerulein exhibited the dose-response character. They were more pronounced when cerulein was injected during phase 2b or 2a MMC when compared with phase 1 MMC. The effects of cerulein on the ileal MMC were less evident, although the inhibition of the ileal phase 3 in response to both higher injected doses was observed occasionally. Infusions of cerulein in non-fasted sheep exerted similar effects as cerulein injections. It was stated that cerulein exerts marked regulatory effect upon the small-intestinal MMC in sheep. Although it remains uncertain whether the efficient doses of cerulein used in the present study correspond to physiological or pharmacological doses of CCK it seems likely that most of these doses were physiological. Thus, it is concluded that cerulein participates in the control of MMC cycles in the digestive and interdigestive states in sheep. It is possible that CCK is a physiological regulator of the ovine small-intestinal MMC.

show abstract

The evaluation of the role of CCK in the opioid modulation of the motility of the gastrointestinal tract in sheep

Cited by 11 publications

References 20 publications

The effect of cholecystokinin octapeptide upon the migrating myoelectric complex in the ovine small bowel

The effect of cholecystokinin octapeptide upon the migrating myoelectric complex in the ovine small bowel

Voltage-Gated Calcium Channel Antagonists: Potential Analgesics for Jejunal Pains

Regional differences in the effects of various doses of cerulein upon the small‐intestinal migrating motor complex in fasted and non‐fasted sheep

Contact Info

Product

Resources

About