The evaluation of viscous ophthalmic vehicles by slit lamp fluorophotometry in humans

Ludwig, Annick; Ooteghem, M. Van

doi:10.1016/0378-5173(89)90328-1

Cited by 27 publications

(5 citation statements)

References 15 publications

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“…They suggested that HA interacts directly with the cell membranes of the corneal tissue. Ludwig et al confirmed those results . They showed that high molecular weight HA (Healon) prolongs the retention of fluorescein in the precorneal area of human eyes.…”

Section: 11 Ophthalmologymentioning

confidence: 83%

“…Ludwig et al confirmed those results. 243 They showed that high molecular weight HA (Healon) prolongs the retention of fluorescein in the precorneal area of human eyes. They compared the HA solutions with equiviscous hydroxyethylcellulose solutions and found that both polymers improved significantly the residence of fluorescein in the tear film.…”

Section: Ophthalmologymentioning

confidence: 99%

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Hyaluronan: Preparation, Structure, Properties, and Applications

Lapčík

Smedt²,

Demeester³

et al. 1998

Chem. Rev.

671

313

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under Prof. S. Claesson. Holding 24 industrial patents and author of more than 120 publications, he has lectured at several European universities. His current interest is in the photochemistry and physical chemistry of polymers. He is a member of the Czech Chemical Society. Stefaan De Smedt was born in Geraardsbergen, Belgium, in 1967. He studied pharmacy at the University of Ghent, Belgium, and received his M.S. degree in pharmaceutical sciences in 1990. As a scholar of the Belgian Institute for the Encouragement of Scientific Research in Industry and Agriculture, he enrolled in a Ph.D. program at the University of Ghent, under the direction of Prof. J. Demeester. He studied rheology at the Catholic University of Leuven. He received the Scott Blair Biorheology Award in 1993−1995 for his work on the structural characterization of hyaluronan solutions. To study diffusion phenomena in polymer solutions, he collaborated with Prof. Y. Engelborghs at the Laboratory of Biomolecular Dynamics of the Catholic University of Leuven. In 1995, he joined the pharmaceutical development group of Janssen Research Foundation. Since 1997 he has been a postdoctoral fellow of F.W.O.-Vlaanderen at the Laboratory of General Biochemistry and Physical Pharmacy of the University of Ghent. He is a member of the Controlled Release Society, the European Federation for Pharmaceutical Sciences, the Belgian Society for Pharmaceutical Sciences, the European Society of Rheology, the Belgian Biophysical Society, and the Polymer Networks Group. He is a consultant to the Journal of Controlled Release and to Pharmaceutical Research. His current research interests include the mobility and interactions of macromolecular drugs in pharmaceutical polymer matrixes and biological polymer systems.

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Section: 11 Ophthalmologymentioning

confidence: 83%

Section: Ophthalmologymentioning

confidence: 99%

Hyaluronan: Preparation, Structure, Properties, and Applications

Lapčík

Smedt²,

Demeester³

et al. 1998

Chem. Rev.

671

313

View full text Add to dashboard Cite

show abstract

“…The increased viscosity value can increase the retention time of formulations on the application area especially for topical formulations [36]. However, it has been proved that the addition of water-soluble polymer excipient into eye drops only delayed the elimination of drugs in the first few minutes, but not improve local bioavailability significantly [37]. Therefore, it is necessary to investigate the rheology behaviors of AZI-SH and AZI-HPMC eye formulations to evaluate whether the viscosity of these two formulations affects the retention time of the formulations and the bioavailability of AZI.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Evaluation of Topically Applied Azithromycin Based on Sodium Hyaluronate in Treatment of Conjunctivitis

Chen

Yin

et al. 2019

Pharmaceutics

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Azithromycin (AZI) eye drops containing sodium hyaluronate (SH) were developed to improve the bioavailability of AZI. Interaction between AZI and SH in the AZI-SH formulation was investigated by differential scanning calorimetry, X-ray diffraction, and 1H-nuclear magnetic resonance spectroscopy analyses. Moreover, advantages of using SH as an excipient were investigated by comparing physiological properties and pharmacokinetic behaviors of SH-containing AZI eye drops with that of hydroxypropyl methylcellulose (HPMC)-containing formulation. In addition, safety of the developed AZI-SH eye drops was evaluated by in vitro 3-(4,5-dimethyl-2-Thiazyl)-2, 5-diphenyl-2H-tetrazolium bromide assay (MTT assay) and neutral red uptake assay as well as in vivo eye irritation test and acute toxicity test. The results indicated that AZI formed a complex with SH under a slightly acidic condition. The area under the curve (AUC) of AZI in SH-containing formulation was 1.58-fold higher (P<0.01) than that in HPMC-containing formulation due to the interaction between the amine group of AZI and the carboxyl group of SH, despite of the higher viscosity of HPMC-containing formulation. Safety evaluation showed that AZI-SH eye drops caused no obvious eye irritation and acute toxicity. In conclusion, the developed SH-containing AZI formulation possessing advantages of longer retention time and higher drug availability was a promising drug formulation for topical ocular therapy.

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“…0 administration. [48] For buccal medication administration, starch-based Mucoadhesive patches and tablets are frequently used. The oral mucosa is adhered to by these formulations, which guarantees extended contact with the mucosal surface and improves medication absorption.…”

Section: Starchmentioning

confidence: 99%

Mucoadhesive Drug Delivery System and There Future Prospective: Are a Promising Approach for Effective Treatment?

Singh,

Chaurasia,

Rajput

et al. 2023

CJAP

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Mucoadhesive polymers are a new and exciting development in drug delivery systems that have the potential to significantly increase therapeutic efficacy. These polymers stick to mucosal surfaces, increasing the amount of time that medications stay at the site of absorption and improving their bioavailability. These mechanisms include longer contact times with the mucosal surface, better drug solubility, and defence against enzymatic degradation of pharmaceuticals. Mucoadhesive polymers also provide a number of benefits over traditional drug delivery methods, including less frequent dosage, better patient compliance, and fewer adverse effects. Due to their adaptability, Mucoadhesive polymers may be used in the rectal, vaginal, ophthalmic, nasal, and oral routes of drug delivery. Mucoadhesive polymers have advantages now, but they also have potential for the future of medication delivery. Mucoadhesion offers excellent possibilities for the delivery of a range of substances through the nasal, vaginal, buccal, and ocular routes of administration. Furthermore, mucoadhesion facilitates the achievement of an extended local or systemic pharmacological effect. In this study, we covered the mechanisms behind mucoadhesion, possible uses for Mucoadhesive polymers in drug administration, and techniques for assessing Mucoadhesive drug delivery systems. The goal of current research is to create innovative Mucoadhesive polymers that have better biodegradability, biocompatibility, and adhesive qualities. Moreover, it is anticipated that the effectiveness of Mucoadhesive polymers would be increased when combined with other cutting-edge drug delivery technologies, such as micro particles and nanoparticles.

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The evaluation of viscous ophthalmic vehicles by slit lamp fluorophotometry in humans

Cited by 27 publications

References 15 publications

Hyaluronan: Preparation, Structure, Properties, and Applications

Hyaluronan: Preparation, Structure, Properties, and Applications

Preparation and Evaluation of Topically Applied Azithromycin Based on Sodium Hyaluronate in Treatment of Conjunctivitis

Mucoadhesive Drug Delivery System and There Future Prospective: Are a Promising Approach for Effective Treatment?

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