The evidence for clinical efficacy of rose hip and seed: a systematic review

Chrubasik, C; Duke, Rujee K.; Chrubasik, Sigrun

doi:10.1002/ptr.1729

Cited by 81 publications

(55 citation statements)

References 17 publications

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“…Two authors (CC and SC) extracted the data independently and evaluated the quality of the studies and the strength of the evidence of clinical effectiveness using the same criteria as in previous reviews , Gagnier et al, 2004, Chrubasik et al, 2006, 2007a,b, 2008, Vlachojannis et al, 2009, 2010a.…”

Section: Methodsmentioning

confidence: 99%

The clinical effectiveness of chokeberry: a systematic review

Chrubasik

2010

Phytotherapy Research

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Products derived from the black chokeberry, Aronia melanocarpa, are claimed to be beneficial in disorders or diseases associated with oxidative stress. The claims are based on evidence from in vitro studies and animal experiments. The active principle – a mixture of procyanidins, anthocyanins and phenolic acids – constitutes one of the most potent natural antioxidants. A systematic review was carried out of the quality of the clinical trials on chokeberry products that had been published up to December 2009, and conventionally established criteria were used to assess the strength of the evidence for their clinical effectiveness. Thirteen studies were identified. The quality of most of the trials and, correspondingly, the evidence of effectiveness for Aronia products is poor. Though laboratory and clinical data indicate that chokeberry products may well be useful as ‘functional food’ for disorders or diseases related to oxidative stress, these promising indications need to be confirmed in more rigorous studies before putative therapeutic uses can be confidently recommended for chokeberry products. Copyright © 2010 John Wiley & Sons, Ltd.

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Section: Methodsmentioning

confidence: 99%

The clinical effectiveness of chokeberry: a systematic review

Chrubasik

2010

Phytotherapy Research

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132

101

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“…(2017) 14(2):1-8 doi:10.21010/ajtcam.v14i2.1 et al, 2010, 2011). In addition, other clinical trial reported that the antioxidant activity could contribute to the pharmaceutical effect of Rosa canina rose hips preparation (Chrubasik et al, 2006.…”

Section: Ferric Reducing Potentialmentioning

confidence: 99%

Antioxidant Activity and Α -Amylase Inhibitory Potential of Rosa Canina L

Jemaa

Jemia

Sarra

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Diabetes mellitus is one of the most common endocrinal disorders and medicinal plants continue to play an important role in the management of this disease. In this study, Rosa canina was investigated for the antioxidant and α-amylase inhibition activities. Materials and Methods: Methanolic extract of Rosa canina was investigated for its potential antioxidant activity. The extracts' total phenolic and flavonoid contents and scavenging capacity for free radicals were evaluated. The α-amylase inhibition assay was also carried. Results: Rosa canina extract exhibits a total Phenolic and flavonoid levels respectively (21.918 mg GAE/g and 2.647mg ER/g). The free radical scavenging activity was found to be prominent against DPPH with an IC50 of 0.668 mg/ml and against ABTS with an IC50 of 0.467 mg/ml. Extract showed a significant ferric ion reducing activities with an IC50 of4.962 mg/ml. Conclusion: Rosa canina exerted a higher inhibitory activity against α-amylase. The obtained results support the antidiabetic use of rosa canina.

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“…Rosehip has a particularly high vitamin C content compared with other fruits and vegetables (14,15), and contains other vitamins, minerals, sugars, fatty acids and flavonoids (14). Rosehip has traditionally been administered for the treatment of colds, infectious diseases and inflammatory diseases (16). In support of its traditional uses, various studies have reported that rosehip exhibited bioactivity, including antioxidant (17,18), anti-inflammatory (19)(20)(21)(22), hepatoprotective (23), anti-diabetic (17) and anti-obesity (24) effects.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, rosehip may be considered a functional food that promotes health. Although rosehip has traditionally been administered for treating uric acid (urate) metabolism disorders (16), its effects have not been characterized in detail.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, it has previously been demonstrated that beverages and food, such as beer, red wine, black and herbal tea, garlic, spices, mace, nutmeg, fruit and fruit juice, tomato juice, and licorice root inhibited enzyme-mediated drug metabolism (9,10,(35)(36)(37)(38)(39). Although rosehip has been used as a food and as a traditional medicine (16), to the best of our knowledge, there is no evidence of an interaction between rosehip and CYP3A4-metabolizing drugs.…”

Section: Introductionmentioning

confidence: 99%

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Rosehip inhibits xanthine oxidase activity and reduces serum urate levels in a mouse model of hyperuricemia

et al. 2017

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Abstract. Rosehip, the fruit of Rosa canina L., has traditionally been used to treat urate metabolism disorders; however, its effects on such disorders have not been characterized in detail. Therefore, the present study investigated the effects of hot water, ethanol and ethyl acetate extracts of rosehip on xanthine oxidase (XO) activity in vitro. In addition, the serum urate lowering effects of the rosehip hot water extract in a mouse model of hyperuricemia (male ddY mice, which were intraperitoneally injected with potassium oxonate) were investigated. Furthermore, the influence of rosehip hot water extract on CYP3A4 activity, which is the most important drug-metabolizing enzyme from a herb-drug interaction perspective, was investigated. Rosehip extracts of hot water, ethanol and ethyl acetate inhibited XO activity [half maximal inhibitory concentration (IC 50 ) values: 259.6±50.6, 242.5±46.2 and 1,462.8±544.2 µg/ml, respectively]. Furthermore, the administration of 1X rosehip hot water extract significantly reduced the levels of serum urate at 8 h, which was similar when compared with the administration of 1 mg/kg allopurinol. Rosehip hot water extract only marginally affected CYP3A4 activity (IC 50 value, >1 mg/ml). These findings indicate that rosehip hot water extract may present as a functional food for individuals with a high urate level, and as a therapeutic reagent for hyperuricemic patients.

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The evidence for clinical efficacy of rose hip and seed: a systematic review

Abstract: Moderate evidence exists for the use of a powder of the seeds and husks of a Rosa canina subspecies in patients suffering from osteoarthritis.

Cited by 81 publications

References 17 publications

The clinical effectiveness of chokeberry: a systematic review

The clinical effectiveness of chokeberry: a systematic review

Antioxidant Activity and Α -Amylase Inhibitory Potential of Rosa Canina L

Rosehip inhibits xanthine oxidase activity and reduces serum urate levels in a mouse model of hyperuricemia

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