1998
DOI: 10.1016/s1078-5884(98)80066-x
|View full text |Cite
|
Sign up to set email alerts
|

The evidence for exercise-induced inflammation in intermittent claudication: Should we encourage patients to stop walking?

Abstract: Further studies are needed to determine the effect of long-term exercise training on exercise-induced inflammation in claudication. Early work suggests, in fact, that exercise attenuates this inflammatory response. If this were confirmed then it would support the clinical impression that exercise training is beneficial in terms of symptomatic improvement and cardiovascular health in patients with intermittent claudication.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
45
1

Year Published

2000
2000
2016
2016

Publication Types

Select...
8
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 54 publications
(46 citation statements)
references
References 96 publications
0
45
1
Order By: Relevance
“…Recent evidence suggests that intermittent claudication sustains an inflammatory state of the muscle. 25 However, it is unknown whether such an inflammatory state creates the conditions for cytokines to exert an angiogenic effect, how long after exercise the inflammatory state persists, and whether it occurs in proximity to occluded arteries, in which neovascularization may be beneficial, or in tissues remote and downstream from diseased arteries. Thus, it is important that angiogenesis may be induced in normoperfused skeletal muscles, in the absence of an inflammatory state that may result from intermittent episodes of arterial insufficiency.…”
Section: Discussionmentioning
confidence: 99%
“…Recent evidence suggests that intermittent claudication sustains an inflammatory state of the muscle. 25 However, it is unknown whether such an inflammatory state creates the conditions for cytokines to exert an angiogenic effect, how long after exercise the inflammatory state persists, and whether it occurs in proximity to occluded arteries, in which neovascularization may be beneficial, or in tissues remote and downstream from diseased arteries. Thus, it is important that angiogenesis may be induced in normoperfused skeletal muscles, in the absence of an inflammatory state that may result from intermittent episodes of arterial insufficiency.…”
Section: Discussionmentioning
confidence: 99%
“…In patients with moderate ischaemia, blood flow and oxygenation are sufficient. However, exercise to the onset of calf pain may cause temporary ischaemia and the phenomenon of the ischaemia reperfusion injury with free radical formation [22].…”
Section: Discussionmentioning
confidence: 99%
“…Certainly, too small amounts of physical exercise means that 3 the human body atrophies and that the risks of several diseases, including coronary heart disease, hypertension, stroke, diabetes, depression, osteoporosis, and cancers of the breast and colon, increase (Garrett et al, 2004). However, too much or too intensive physical exercise means that the human body will wear down and/or that the risk of injury increases (Tisi and Shearman, 1998;Locke, 1999;Ji, 2001;Randolph, 2007;Howatson G and van Someren, 2008;Morton et al, 2009). A varied and balanced diet is emphasised in guidelines on healthy eating; see, for instance (Swedish National Food Agency, 2012).…”
Section: Figure 1 About Herementioning
confidence: 99%