2022
DOI: 10.15406/ijfcm.2022.06.00255
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The evolution and global impact of Covid-19 and Omicron: the way forward?

Abstract: Coronaviruses are a family of pathogenic viruses that including MERS, SARS, and SARS-Cov-2, and are known to cause respiratory and other illnesses in man and animals. The SARS-CoV-2 virus, responsible for the COVID-19 virus is a monopleiotropic clade of the coronavirus family first reported in Wuhan, China in December 2019 where it was found to cause a previously unreported form of viral pneumonia. The virus readily spreads by airborne microdroplet infection, and within a month of its report to the WHO in Dece… Show more

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Cited by 2 publications
(14 citation statements)
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“…Once the adipose tissue becomes infected, it initiates the release of inflammatory cytokines including IL-6, TNF and others which can lead to a serious and an often-fatal cytokine storm. 12 Since human obesity develops via hyperplasia and hypertrophy of preadipocytes, the adipocytes once differentiated retain their cell surface receptor domains and intracellular biosynthetic functions thereafter, similar to the receptive surfaces of tissues of other organs. The increased adipose mass thus formed, especially when combined increasing BMI, glucose intolerance, and an increased visceral adipose tissue mass and additional comorbidities often including NIDDM, IT appears to reflect a proportionately greater risk of cytokine mediated COVID-19 complications.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…Once the adipose tissue becomes infected, it initiates the release of inflammatory cytokines including IL-6, TNF and others which can lead to a serious and an often-fatal cytokine storm. 12 Since human obesity develops via hyperplasia and hypertrophy of preadipocytes, the adipocytes once differentiated retain their cell surface receptor domains and intracellular biosynthetic functions thereafter, similar to the receptive surfaces of tissues of other organs. The increased adipose mass thus formed, especially when combined increasing BMI, glucose intolerance, and an increased visceral adipose tissue mass and additional comorbidities often including NIDDM, IT appears to reflect a proportionately greater risk of cytokine mediated COVID-19 complications.…”
Section: Discussionmentioning
confidence: 99%
“…8,10 Once receptive tissues become infected with the virus, the intracellular viral replication occurs rapidly and may spread to other receptive tissues including adipose and other tissues, while immune responses tend to lag behind the viral replicative events. 5,12 In severe cases, death may occur due to a combination of the additive impact of the virus and comorbidities, and the more advanced the individual or multiple comorbidities, the more severe magnitude of illness may occur. 8,21 Restoration of a healthy BMI in obesity is typically a gradual and often unrewarding process, and often only temporary in duration as weight regain occurs easily when therapeutic regimens are discontinued.…”
Section: Discussionmentioning
confidence: 99%
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“…23--25 The complete numbers of individuals confirmed to have become infected or died from the virus may never be known for sure, however due to presumed incomplete reporting and inadequate availability of reliable diagnostics in concert with strained economic and medical resources by some countries, in addition to the recognition of prolonged symptoms, now designated as a 'long covid' complication of COVID-19. 11,25,27 Of interest, multiple vaccines were developed and marketed in less than a year from the outset of their development, marking this the shortest time to develop, test and release a new vaccine in history in any nation. 10…”
Section: The Covid-19 Pandemic Is the First Pandemic Of The 21 St Cen...mentioning
confidence: 99%