The Evolution of a Biodegradable Membrane for Use in Urological Surgery A summary of 109 <i>in vivo</i> Experiments

Scott, Robert N.; Mohammed, Rabab Ahmed Ahmed; Gorham, S. D.; French, D. A.; Monsour, Michael; Shivas, A A; Hyland, T.P.

doi:10.1111/j.1464-410x.1988.tb04259.x

Cited by 39 publications

(20 citation statements)

References 18 publications

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“…In our studies, no attempt was made to divert urine from the urinary tract, and hence a normal physiological movement of the bladder was able to take place. Blocks prepared for histology in our two series of experiments [1,2] were serially sectioned to show that islets of smooth muscle present in the repair area were not arising from the pre-existing detrusor muscle. Our results therefore show that, under the conditions of our experiments, when a full thickness defect of the urinary bladder is replaced by a biodegradable membrane, smooth muscle regeneration can occur within the granu lation tissue of the repair site, presumably as a result of myoblastic differentiation.…”

Section: Resultsmentioning

confidence: 99%

“…The repair of full thickness defects in the urinary bladder of 43 mature rabbits has already been described [1,2], From these two series of experiments, samples were obtained in which there was clear evidence of smooth muscle regeneration both at the margins and within the repair site. By re-examining the material already produced, the samples used to illustrate this paper were obtained.…”

Section: Methodsmentioning

confidence: 99%

“…In the present study we re-examined some of our find ings in which we used a composite membrane of collagen and Vicryl to repair full thickness defects created in the wall of the urinary bladder of rabbits [1,2], A full thick ness section of bladder tissue was removed and replaced by a 1.5 X 1.5 cm piece of collagen/Vicryl composite membrane. While healing was taking place, no attempt was made to divert the urine from the urinary tract dur ing these experiments.…”

Section: Introductionmentioning

confidence: 99%

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Some Observations on the Regeneration of Smooth Muscle in the Repaired Urinary Bladder of the Rabbit

Gorham

French²,

Shivas³

et al. 1989

Eur Urol

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Some Observations on the Regeneration of Smooth Muscle in the Repaired Urinary Bladder of the Rabbit

Gorham

French²,

Shivas³

et al. 1989

Eur Urol

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“…[4][5][6][7][8] Collagenrich biodegradable materials such as placenta, amnion and pericardium have been used with more success than nonbiodegradable materials. [9][10][11][12] However, none of these materials has been found to be suitable for clinical use.…”

Section: Discussionmentioning

confidence: 99%

Penile enhancement using a porcine small intestinal submucosa graft in a rat model

2005

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Several biodegradable materials have been experimented for penile enhancement, but none show the potential for clinical use. This study was designed to use porcine small intestinal submucosa (SIS) augmenting the normal tunica albuginea to increase the functional girth of the rat penis. In all, 20 adult male Sprague-Dawley rats constituted the study population. The animals were divided into two groups: group 1 consisted of the control (n ¼ 10) and group 2 (n ¼ 10) consisted of rats that underwent penile enhancement by a longitudinal I-shaped incision of the tunica albuginea on both sides, and the dissection of the plane between tunica albuginea and cavernosal tissue was carried out (n ¼ 10). The incision was then patched with a 3 Â 10 mm 2 piece of SIS, using a 6/0 nylon suture material. The penile length and mid-circumference were then measured using a Vernier Caliper before and 2 months after surgery. All rat penises underwent histological examination using Masson's trichome and Verhoff's van Giesen's stain for collagen and elastic fibers. The penile length, mid-circumference and degree of fibrosis score were expressed as mean7s.e. (standard error) and analyzed using a Wilcoxon rank-sum test. A statistical significance was accepted at P-value p0.05. Our results showed similar preoperative penile length and circumference in both groups. However, 2 months after the surgery, the mean penile circumference of the SIS group has grown significantly larger than the control group, while the mean penile length remained unchanged. The histological study of the rat penises revealed minimal amounts of fibrosis under the graft, and the elastic fibers of the graft showed orientation in a circular manner. In conclusion, SIS appears promising for material use in a penile enhancement.

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“…However, these grafts were quickly encrusted, prone to infection and subject to host-foreign body reactions. [1][2][3][4][5] The unfavourable outcomes related to these materials led to the development of grafts that were biodegradable, minimally immunogenic and demonstrated the ingrowth of native cells necessary for successful tissue regeneration. Omentum, peritoneum, placenta, pericardium and dura have served as alternatives for the bladder wall.…”

Section: Introductionmentioning

confidence: 99%

Tissue engineering in urology

Matoka

Cheng

2013

CUAJ

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Tissue engineering encompasses a multidisciplinary approach geared toward the development of biological substitutes designed to restore and maintain normal function in diseased or injured tissues. This article reviews the basic technology that is used to generate implantable tissue-engineered grafts in vitro that will exhibit characteristics in vivo consistent with the physiology and function of the equivalent healthy tissue. We also examine the current trends in tissue engineering designed to tailor scaffold construction, promote angiogenesis and identify an optimal seeded cell source. Finally, we describe several currently applied therapeutic modalities that use a tissue-engineered construct. While notable progress has clearly been demonstrated in this emerging field, these efforts have not yet translated into widespread clinical applicability. With continued development and innovation, there is optimism that the tremendous potential of this field will be realized.Can Urol Assoc J 2009;3(5):403-8 Résumé L'ingénierie tissulaire englobe une approche multidisciplinaire axée sur le développement de substituts biologiques en vue de rétablir et de maintenir la fonction normale de tissus lésés. L'article qui suit passe en revue la technologie fondamentale utilisée pour générer des greffons implantables produits par ingénierie in vitro et possédant des caractéristiques in vivo correspondant aux tissus sains équivalents sur les plans physiologique et fonctionnel. Nous examinons également les tendances actuelles en ingénierie tissulaire visant à adapter des échafaudages tissulaires, à promouvoir l'angiogenèse et à dégager une source optimale de cellules implantables. Enfin, nous décrivons plusieurs modalités thérapeu-tiques actuellement mises en application utilisant un échafaudage créé par ingénierie tissulaire. En dépit de progrès remarquables dans ce domaine en effervescence, les efforts déployés ne se sont pas encore traduits par une applicabilité clinique étendue. Des développements et des percées continus permettent d'être optimiste face au potentiel prodigieux de ce domaine.

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The Evolution of a Biodegradable Membrane for Use in Urological Surgery A summary of 109 in vivo Experiments

Cited by 39 publications

References 18 publications

Some Observations on the Regeneration of Smooth Muscle in the Repaired Urinary Bladder of the Rabbit

Some Observations on the Regeneration of Smooth Muscle in the Repaired Urinary Bladder of the Rabbit

Penile enhancement using a porcine small intestinal submucosa graft in a rat model

Tissue engineering in urology

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