The evolution of a pleural nodule into a giant fibrous tumor associated with hypoglycemic coma

D’Andrilli, Antonio; Andreetti, Claudio; Ibrahim, Mohsen; Rendina, Erino Angelo

doi:10.1016/j.ejcts.2007.01.039

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…On the other hand, the most common symptoms are cough and chest pain (11,12). Other rare symptoms are fever, more than 10% body weight loss, pleural effusion, hypertrophic osteoarthropathy, clubbing, galactorrhea, and hypoglycemia that disappears in 3 to 4 days after surgery (3,(16)(17)(18). None of these rare symptoms and laboratory findings was seen in our patients.…”

Section: Discussionmentioning

confidence: 61%

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

et al. 2016

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IntroductionPrimary tumors of the pleura are classified as diffuse and solitary. The solitary form was thought to be a form of mesothelioma and received different names such as localized mesothelioma, subpleural fibroma, benign mesothelioma, and subserous fibroma (1,2). It is recognized that the solitary fibrous tumor of the pleura (SFTP), which is rare and grows slowly, originates from mesenchymal cells of the submesothelial tissue of the pleura (3,4). No reports have demonstrated a correlation between SFTP and exposure to asbestos or any other carcinogens (5,6). Over 80% of these tumors are benign (1,4,7). They mostly appear between the 4th and 7th decades of life, half of them are asymptomatic, and they manifest as rounded, homogeneous masses with smooth margins on routine radiograms (8,9). Preoperative diagnosis is difficult because of nonspecific radiographic findings, and complete resection is the best prognostic factor (10-13).The aim of the present study was to identify any common or remarkable etiological factor or any biochemical abnormality or clinical presentation of SFTP, as well as to examine the best appropriate surgical approach and the results of long-term follow-up, and to compare these parameters with those reported in the literature. Materials and methodsBetween January 2001 and October 2014 the clinical and long-term follow-up records of 14 patients who had had surgery for SFTP were reviewed retrospectively. Common etiological factors, diagnostic procedures, and the clinical courses and outcomes for these patients were evaluated. The diagnosis of SFTP was confirmed by histomorphologic and immunohistochemical staining with hematoxylin/ eosin, CD34, vimentin, and cytokeratin. Malignancy criteria were described by England et al. (14) as more than 4 mitoses per 10 high-power fields, the presence of necrosis, and nuclear crowding and overlapping, which was defined as high cellularity and nuclear atypia. When one or more of these criteria was found histologically, the fibrous tumor was categorized as malignant (2,4). The classification of staging was based on de Perrot et al. Background/aim:The aim of the present study was to evaluate the etiology and clinical and pathological behavior of solitary fibrous tumors of the pleura (SFTPs), as well as the most appropriate surgical approach and the results of long-term follow-up of this condition.Materials and methods: Clinical and long-term follow-up records of 14 patients who had surgery for SFTP between 2001 and 2014 were reviewed retrospectively. Etiological factors, diagnostic procedures, and clinical courses and outcomes for these patients were studied.Results: Of the 14 patients, 8 were male (57%) and 6 were female (43%) patients. The mean age was 54.14 ± 10.35 (41-75) years. There was no remarkable common etiological factor. Preoperative diagnosis was achieved only in 2 patients. Predominant symptoms were cough and chest pain. Complete resection was achieved in all patients. Video-assisted thoracic surgery (VATS) was performed in 8 patients. All ...

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Section: Discussionmentioning

confidence: 61%

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

et al. 2016

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“…The best and the only demonstrated effective treatment of SFTP is surgical resection removing pulmonary parenchyma compression and allowing the reexpansion of the lung. [ 1 3 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 ] The best therapy for SFTP is complete surgical resection with a long-term follow-up. [ 1 3 ] We present two cases of SFTP in two different patients, a new mother with a polyarticular paraneoplastic syndrome and an old man with obstructive pulmonary disease who had underestimated the occasional finding on the chest x-ray of a pulmonary small peripheral mass 4 years before.…”

Section: Introductionmentioning

confidence: 99%

Different clinical and radiological features of solitary fibrous tumor of the pleura: Report of two cases

et al. 2016

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We report two cases of solitary fibrous tumor of the pleura (SFTP). The first appeared in a young, new mother as a large mass in the upper lobe of the left lung that caused compression of lung parenchyma without significant respiratory symptoms but with polyarticular paraneoplastic syndrome; the other was documented by an occasional chest x-ray in a man affected by chronic obstructive pulmonary disease (COPD) as a small peripheral mass 4 years before and no longer controlled. Both patients underwent surgical resection with quick and full recovery. SFTP is a benign, slow growing neoplasm that is mostly localized. It appears in adult or elderly patients often with few symptoms. The computed tomography (CT) of the chest with contrast medium is important in order to see the shape of the mass and relationships with adjacent structures but only histology can provide the diagnosis. Surgery is the best treatment.

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Giant Solitary Fibrous Tumor of the Pleura (SFTPs) associated with paraneoplastic Doege Potter Syndrome

Marla

Swethadri

Naik

et al. 2011

Indian J Thorac Cardiovasc Surg

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The evolution of a pleural nodule into a giant fibrous tumor associated with hypoglycemic coma

Cited by 5 publications

References 8 publications

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

Different clinical and radiological features of solitary fibrous tumor of the pleura: Report of two cases

Giant Solitary Fibrous Tumor of the Pleura (SFTPs) associated with paraneoplastic Doege Potter Syndrome

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