The evolution of bone marrow signal changes at the skull base in nasopharyngeal carcinoma patients treated with radiation therapy

Parlak, Şafak; Yazıcı, Gözde; Dolgun, Anıl; Özgen, Burçe

doi:10.1007/s11547-021-01342-y

Cited by 4 publications

(7 citation statements)

References 27 publications

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“…In addition to assisting in determining the nature of the lesion, another important role of enhanced MRI is to help clinicians predict the extent of the tumor invasion and observe the relationship between the tumor and surrounding important structures [ 34 ]. It is important to note that patients with a suspected possibility of tumor recurrence have generally received radiation therapy, and sometimes there is a post-radiation effect that causes non-tumor tissues to appear as high-signal images in enhanced MRI, which may affect the clinician’s diagnosis [ 35 ]. Enhanced MRI also plays an important role in the post-treatment review process [ 36 ].…”

Section: Clinical Symptom and Diagnosis Of Recurrent Npcmentioning

confidence: 99%

Treatment of Recurrent Nasopharyngeal Carcinoma: A Sequential Challenge

Peng

Wang

Fan

et al. 2022

Cancers

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Recurrent nasopharyngeal carcinoma (NPC), which occurs in 10–20% of patients with primary NPC after the initial treatment modality of intensity-modulated radiation therapy (IMRT), is one of the major causes of death among NPC patients. Patients with recurrent disease without distant metastases still have a chance to be saved, but re-treatment often carries more serious toxicities or higher risks. For this group of patients, both otolaryngologists and oncologists are committed to developing more appropriate treatment regimens that can prolong patient survival and improve survival therapy. Currently, there are no international guidelines for the treatment of patients with recurrent NPC. In this article, we summarize past publications on clinical research and mechanistic studies related to recurrent NPC, combined with the experience and lessons learned by our institutional multidisciplinary team in the treatment of recurrent NPC. We propose an objective protocol for the treatment of recurrent NPC.

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Section: Clinical Symptom and Diagnosis Of Recurrent Npcmentioning

confidence: 99%

Treatment of Recurrent Nasopharyngeal Carcinoma: A Sequential Challenge

Peng

Wang

Fan

et al. 2022

Cancers

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Section: Discussionmentioning

confidence: 97%

“…OC invasion at initial diagnosis is a poor factor for survival of T3 stage NPC patients [ 6 ]. Previously studies found the signal intensity of OC is related to age and gender [ 9 ], and abnormal residual OC signal could persist several years after radiotherapy without recurrence [ 27 ], which make the identification of OC invasion and recurrence somewhat difficult. In addition, according to the criteria reported in studies [ 26 – 28 ], contrast-enhanced sequences are an indispensable examination, so false-positive is more likely to occur in people who only performed non-enhanced scans.…”

Section: Discussionmentioning

confidence: 99%

“…The OC invasion was considered positive in cases: low-intensity on T1WI, hyperintensity on T2WI and enhancement on contrast-enhanced T1WI with fat-suppressed, as well as erosion or sclerosis of the bone cortex on CT [26][27][28]. The diagnosis obtained from MRI imaging was used when there had difference among CT and MR image findings for bone marrow invasion.…”

Section: Image Processing and Segmentationmentioning

confidence: 99%

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The utility of texture analysis based on quantitative synthetic magnetic resonance imaging in nasopharyngeal carcinoma: a preliminary study

Yang

et al. 2023

BMC Med Imaging

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Background Magnetic resonance imaging (MRI) is commonly used for the diagnosis of nasopharyngeal carcinoma (NPC) and occipital clivus (OC) invasion, but a proportion of lesions may be missed using non-enhanced MRI. The purpose of this study is to investigate the diagnostic performance of synthetic magnetic resonance imaging (SyMRI) in differentiating NPC from nasopharyngeal hyperplasia (NPH), as well as evaluating OC invasion. Methods Fifty-nine patients with NPC and 48 volunteers who underwent SyMRI examination were prospectively enrolled. Eighteen first-order features were extracted from VOIs (primary tumours, benign mucosa, and OC). Statistical comparisons were conducted between groups using the independent-samples t-test and the Mann–Whitney U test to select significant parameters. Multiple diagnostic models were then constructed using multivariate logistic analysis. The diagnostic performance of the models was calculated by receiver operating characteristics (ROC) curve analysis and compared using the DeLong test. Bootstrap and 5-folds cross-validation were applied to avoid overfitting. Results The T1, T2 and PD map-derived models had excellent diagnostic performance in the discrimination between NPC and NPH in volunteers, with area under the curves (AUCs) of 0.975, 0.972 and 0.986, respectively. Besides, SyMRI models also showed excellent performance in distinguishing OC invasion from non-invasion (AUC: 0.913–0.997). Notably, the T1 map-derived model showed the highest diagnostic performance with an AUC, sensitivity, specificity, and accuracy of 0.997, 96.9%, 97.9% and 97.5%, respectively. By using 5-folds cross-validation, the bias-corrected AUCs were 0.965–0.984 in discriminating NPC from NPH and 0.889–0.975 in discriminating OC invasion from OC non-invasion. Conclusions SyMRI combined with first-order parameters showed excellent performance in differentiating NPC from NPH, as well as discriminating OC invasion from non-invasion.

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“…MRI has now become a fundamental tool in oncology research and in the clinical management of cancer patients. Among imaging modalities, MRI provides unique and multiparametric access to anatomic, physiologic, biochemical, and molecular details of tumors with excellent spatial and temporal resolution [ 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ].…”

Section: Introductionmentioning

confidence: 99%

Advanced Magnetic Resonance Imaging (MRI) Techniques: Technical Principles and Applications in Nanomedicine

Bruno

Granata

Bellisari

et al. 2022

Cancers

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In the last decades, nanotechnology has been used in a wide range of biomedical applications, both diagnostic and therapeutic. In this scenario, imaging techniques represent a fundamental tool to obtain information about the properties of nanoconstructs and their interactions with the biological environment in preclinical and clinical settings. This paper reviews the state of the art of the application of magnetic resonance imaging in the field of nanomedicine, as well as the use of nanoparticles as diagnostic and therapeutic tools, especially in cancer, including the characteristics that hinder the use of nanoparticles in clinical practice.

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The evolution of bone marrow signal changes at the skull base in nasopharyngeal carcinoma patients treated with radiation therapy

Cited by 4 publications

References 27 publications

Treatment of Recurrent Nasopharyngeal Carcinoma: A Sequential Challenge

Treatment of Recurrent Nasopharyngeal Carcinoma: A Sequential Challenge

The utility of texture analysis based on quantitative synthetic magnetic resonance imaging in nasopharyngeal carcinoma: a preliminary study

Advanced Magnetic Resonance Imaging (MRI) Techniques: Technical Principles and Applications in Nanomedicine

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