The evolution of dengue over a decade in Delhi, India

Pandey, Avinash; Diddi, Kavita; Dar, Lalit; Bharaj, Preeti; Chahar, Harendra Singh; Guleria, Randeep; Kabra, S. K.; Broor, Shobha

doi:10.1016/j.jcv.2007.05.011

Cited by 17 publications

(13 citation statements)

References 3 publications

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“…The low incidence of seropositivity may be due to a delay in the development of adaptive immune responses in the study subjects. The greater proportion of patients with secondary infection in this study is because Delhi is endemic for DENVs and dengue fever outbreaks had occurred in 2010 and 2006 . Four of forty samples were found to be positive with CHIKV‐specific IgM capture ELISA.…”

Section: Discussionmentioning

confidence: 81%

“…Thousands of cases of dengue fever are reported every year in Delhi. Dengue fever epidemics have occurred in Delhi in 1967, 1970, 1982, 1988, 1996, 2003, 2006 and 2010 . Many cases of chikungunya fever are also reported from Delhi; however, the true burden of the disease is largely under‐appreciated because of the similarity of its clinical symptoms to those of dengue fever.…”

Section: Introductionmentioning

confidence: 99%

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Molecular characterization of dengue and chikungunya virus strains circulating in New Delhi, India

Afreen

Deeba

Khan

et al. 2014

Microbiology and Immunology

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Dengue and chikungunya are acute viral infections with overlapping clinical symptoms. Both diseases are transmitted by common mosquito vectors resulting in their co-circulation in a region. Molecular and serological tests specific for both dengue and chikungunya infections were performed on 87 acute phase blood samples collected from patients with suspected dengue/chikungunya infections in Delhi from September to December, 2011. RT-PCR and IgM ELISA were performed to detect dengue virus (DENV) and chikungunya virus (CHIKV). NS1 and IgG ELISA were also performed to detect DENV specific antigen and secondary DENV infection. DENV infection was detected in 49%, CHIKV infection in 29% and co-infection with DENV and CHIKV in 10% of the samples by RT-PCR. DENV serotypes 1, 2 and 3 were detected in this study. Nine DENV-1 strains, six DENV-2 strains and 20 CHIKV strains were characterized by DNA sequencing and phylogenetic analysis of their respective envelope protein genes. DENV-1 strains grouped in the American African genotype, DENV-2 strains in the Cosmopolitan genotype and CHIKV strains in the East Central South African genotype by phylogenetic analysis. This is one of the few studies reporting the phylogeny of two dengue virus serotypes (DENV-1 and DENV-2) and CHIKV. Surveillance and monitoring of DENV and CHIKV strains are important for design of strategies to control impending epidemics.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Molecular characterization of dengue and chikungunya virus strains circulating in New Delhi, India

Afreen

Deeba

Khan

et al. 2014

Microbiology and Immunology

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“…Headache is also one of common presentation 53% but retro-orbital pain which is a classical feature of dengue was seen only in 6% of cases which is much less than other studies but similar to Kapoor at al, 19,22,23 Our clinical findings were similar to that of other previous studies. [8][9][10][11][12] These were GI manifestations like loose stools (17%) and abdominal pain (21%). Rash, mostly of maculo-papular variety, rarely pruritic, seen in extremities and trunk was found in 14 cases (14%).…”

Section: Discussionmentioning

confidence: 99%

“…10 It has also spread from urban to rural regions. 11 Dengue is transmitted by bite of female. Aedes mosquito, Adesaegypti and Aedes albopictus main vectors in India.…”

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confidence: 99%

Clinical spectrum of dengue at a tertiary care hospital in Eastern India

et al. 2019

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Background: Dengue is a vector borne disease by four different serotypes of dengue virus transmitted by bite of female Aedes mosquito. It is an acute febrile illness characterised by myalgia, joint pain, gastrointestinal manifestations. Complications like dengue hemorrhagic fever (DHF) and Dengue shock syndrome (DSS) , Extended Dengue Syndrome(EDS) may be fatal for patients. Authors analyse different clinical spectrum of of manifestations, complications and correlation bleeding to platelet level.Methods: This study conducted from July 2017 to December 2018 comprising of 100 dengue patients of age more than 15 years in IMS & SUM Hospital.Result: Out of 100 dengue patients’ males 73% and females 27%. From the patients 57% were NS1 Antigen positive, 29% IgM positive, 9% NS1 and IgM positive, 4% IgM and IgG positive and 2 % with all NS1, IgM, IgG positive. In our series in clinical manifestations, all cases (100%) presented with fever, myalgia (78%), headache (53%), rashes (14%), nausea, pain abdomen (21%) loose motion (17%), and Retro-orbital pain (6%). Bleeding manifestations in any form was seen in 39% cases like Purpura or Petechie (23%), malena (18%), hematemesis ( 2% ), epixtasis (6%), Gum bleeding (2%), Hematuria (1%), and Ophthalmic bleeding like sub conjunctival hemorrhage, intra-vitreal hemorrhage in 8% cases. Complications detected e.g. hepatopathy in 53%, nephropathy. 4%, ascites 8%, pneumonia 7%, DSS (4%), Multi Organ Dysfunction (MODS) (4%), DHF (8%) and EDS in 2% cases. It was observed that 95.8% of patients with platelet counts between 20,000-50,000/cu.mm and 61% of patients less than 25000 had bleeding manifestations.Conclusion: Wide clinical spectrum of manifestations and complications makes it common differential diagnosis of acute febrile illnesses and bleeding manifestation does not always corelate with lower platelet count.

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“…To date, not many cases of mixed infection with dengue and leptospirosis have been described. Only 4 reports of triple co-infections have been reported [ 2,9,10,11]. ; however, the concurrent rise of leptospirosis during a dengue outbreak has been reported [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Quadruple Co-Infections due to Leptospira, Dengue, Hepatitis E & Round Worm: A Window to Urban Insanitary

2015

IJSR

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Co-infection in a immune competent host is rare. Leptospirosis, Dengue, Hepatitis E and Ascariasis are diseases commonly transmitted in locales with poor hygiene and sanitation and overcrowding. Not too many cases of quadruple co-infection in an immune competent host have been reported. We report a case of mixed infection due to leptospira, dengue, hepatitis E and Ascariasis. Like clinical presentation and simultaneous transmission of these diseases, especially during the monsoon often leads to a dilemma in diagnosis. Early detection of the disease by appropriate laboratory tests and timely institution of therapy is pivotal and life saving.

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The evolution of dengue over a decade in Delhi, India

Cited by 17 publications

References 3 publications

Molecular characterization of dengue and chikungunya virus strains circulating in New Delhi, India

Molecular characterization of dengue and chikungunya virus strains circulating in New Delhi, India

Clinical spectrum of dengue at a tertiary care hospital in Eastern India

Quadruple Co-Infections due to Leptospira, Dengue, Hepatitis E & Round Worm: A Window to Urban Insanitary

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