The Evolution of Human Probiotics: Challenges and Prospects

New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?

“…These approaches attempt to modulate the microbial communities in a way that is beneficial to human health. However, several important questions related to these new clinical strategies remain unresolved, such as indication for prescription, comparative efficacy of monostrain and multistrain probiotics, choice of excipients, and methods of administration and delivery [134]. Furthermore, procedures to develop reliable and reproducible microbiome-based therapeutic approaches represent a challenge [136].…”

“…Furthermore, procedures to develop reliable and reproducible microbiome-based therapeutic approaches represent a challenge [136]. Currently, the pharmacological mechanisms of probiotics and prebiotics' action are poorly understood, providing not enough evidence to support the use of probiotics for medicinal purposes [134]. Of those commercially available probiotics, it is especially difficult to prove their clinical efficacy as they are based on studies on a small sample size, and the heterogeneity in strains of bacteria used, duration of treatment and the lifestyle of patients, which can also influence the effects of probiotic supplementation [167].…”

“…Probiotic bacteria produce bioactive molecules that could act on the body and promote good health. These formulations might be a safe and effective alternative to antibiotics in restoring the imbalance of the uterine microbiota as seen in female urogenital disorders [133,134]. In the clinical setting, there is a high interest and demand to improve aberrant endometrial microbial environment in order to overcome dysbiosis and to enhance infertility treatment outcomes.…”

Technological Characterisation of Probiotic Lactic Acid Bacteria as Starter Cultures for Dry Fermented Sausages

“…Probiotics are defined as 'live microbial food supplements that, when administered in adequate amounts confer a health benefit on the host' [4]. Such probiotic microorganisms are capable of contributing to the balance of the host's intestinal microbiota, modulate immune response and can act in various other ways as health promoters [5]. Until now, the most common use of these microorganisms is in fermented dairy products but some authors propose the use of probiotic lactic acid bacteria (LAB) as starter cultures for fermented meat products [2,[6][7][8][9][10][11].…”

Optimization of process parameters for pickle masala flavored probiotic Greek yoghurt

“…Several species of LAB are industrially formulated to produce fermented food as starter cultures and enhance human health through probiotics. Probiotics alter the intestinal microflora balance, inhibit the growth of pathogen (Wulandari et al 2020), modulate immune response and can act in various other ways as health promoters (Trush et al 2020). Probiotics strains of lactobacillus are usually given generally regarded as safe (GRAS) status, since most are isolated either from traditional dairy products or the gastrointestinal tract of healthy individuals (Salminnen et al 1998).…”