The Evolution of <i>Helicobacter pylori</i> Antibiotics Resistance Over 10 Years in Beijing, China

Gao, Wen; Cheng, Hong; Hu, Fu-lian; Jiang, Li; Wang, Lihui; Yang, Glen; Xu, Lanfang; Zheng, Xiaoli

doi:10.1111/j.1523-5378.2010.00788.x

Cited by 132 publications

(129 citation statements)

References 31 publications

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“…Secondary resistance to levofloxacin (LEV) increased from 38% in 2006 to 82% in 2009. Resistance to ampicillin (AMP) and tetracycline (TET) was consistently negligible (3). A similar trend was observed in a European cohort between 2004 and 2007 where, altogether, secondary CLR resistance was 68%, MET resistance was 75%, and quinolone resistance was 20% (4).…”

Section: Espite 30 Years Of Experience In Treatingsupporting

confidence: 51%

Trends in Secondary Antibiotic Resistance of Helicobacter pylori from 2007 to 2014: Has the Tide Turned?

et al. 2015

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The current guidelines recommend culture and antibiotic susceptibility testing of Helicobacter pylori following two failed eradication attempts. Where testing is unavailable, epidemiological data for secondary H. pylori resistance are essential to allow for the rational use of antibiotics. The aim of this study was to describe the temporal changes in antibiotic resistance among adults previously treated for H. pylori infections and to identify predictors of resistance. Between 2007 and 2014, consecutive patients undergoing gastroscopy with H. pylori culture and susceptibility testing at our institution following at least two treatment failures were retrospectively identified. Antibiotic susceptibilities were recorded and linked to the demographic data. A total of 1,042 patients were identified, including 739 (70.9%) males, aged 39.3 ؎ 18.9 years. Resistance to clarithromycin, metronidazole, and levofloxacin was found in 57.2%, 64.4%, and 5.1% of isolates, respectively. Dual resistance to clarithromycin and metronidazole was seen in 39.9%. Over the study period, clarithromycin resistance increased annually in a linear manner (odds ratio [OR], 1.09; 95% confidence interval [CI], 1.03 to 1.14; P < 0.01), levofloxacin resistance decreased annually (OR, 0.78; 95% CI, 0.61 to 0.92; P < 0.01), and metronidazole resistance was nonlinear. Age was an independent predictor of resistance to all antibiotics. Time elapsed predicted resistance for clarithromycin and levofloxacin and dual resistance for clarithromycinmetronidazole. Secondary resistance of H. pylori to clarithromycin and metronidazole remains high. The low secondary resistance to levofloxacin makes it an attractive treatment option in our region for patients following two failed eradication attempts.

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Section: Espite 30 Years Of Experience In Treatingsupporting

confidence: 51%

Trends in Secondary Antibiotic Resistance of Helicobacter pylori from 2007 to 2014: Has the Tide Turned?

et al. 2015

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“…En nuestro estudio se demostró que el 66% de los aislados presentaba resistencia, valores muy superiores al 12% reportado para América Latina (17) y al 9,5% en el Ecuador, reportado en el 2003 (18). No obstante, Raymont y colaboradores demostraron un incremento en la prevalencia de aislados resistentes a la claritromicina llegando al 68% en pacientes con antecedentes de antibioticoterapia previa (19); un porcentaje similar de resistencia lo demostraron Gao y colaboradores (20).…”

Section: Discussionunclassified

Susceptibilidad antibiótica de Helicobacter pylori: un estudio de prevalencia en pacientes con dispepsia en Quito-Ecuador

Reyes

Guzmán

Morales

et al. 2017

Rev. Colomb. Gastroenterol.

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Introducción: Helicobacter pylori se lo asocia a patologías gastro-intestinales, el incremento en la resistencia a los antibióticos utilizados para su erradicación es alarmante a nivel mundial. En este estudio se determinó la susceptibilidad a cinco antibióticos utilizados en la terapia de erradicación de H. pylori aislado de una población adulta con dispepsia recurrente en Quito-Ecuador.Materiales y métodos: Previa aceptación del consentimiento informado, se tomaron biopsias de cuerpo y fondo gástrico de 210 pacientes con dispepsia, mediante cultivo se recuperaron los aislados de H. pylori identificado mediante pruebas bioquímicas. La susceptibilidad al metronidazol, claritromicina, amoxicilina, tetraciclina y levofloxacina se realizó por concentración mínima inhibitoria (CMI). Todos los cultivos se correlacionaron con el estudio histopatológico.Resultados: Se recuperaron 89 aislados de H. pylori. Se obtuvo un kappa de 0.9 entre el cultivo y el estudio histopatológico. El porcentaje de cepas con resistencia antibiótica fue: metronidazol (63 %), claritromicina (66 %), amoxicilina (43%), tetraciclina (36%) y levofloxacina (54%).Conclusión: Estos hallazgos demuestran la alta resistencia a los antibióticos usados para la erradicación de H. pylori, varios factores como consumo indiscriminado de antibióticos, terapia previa, etc. podrían estar involucrados.Palabras clave: Helicobacter pylori; resistencia antibiótica; concentración mínima inhibitoria.

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“…Prevalence of bacterial resistance to antibiotics varies in different geographic areas and it has been correlated with the consumption of antibiotics in the general population [4,5]. For example, MNZ resistance varies from 10 to 80% among geographic regions [6][7][8][9]. In developing countries antibiotic resistance is considered to be higher than in developed countries.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance of Helicobacter pylori in Mongolia

Bolor-Erdene

Namdag

Yamaoka

et al. 2017

J Infect Dev Ctries

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Introduction.The resistance of Helicobacter pylori to recently available antibiotic treatment regimens has been recognized as a growing problem. Therefore, the aim of this study was to determine the prevalence of antibiotic resistance among H. pylori strains isolated from Mongolians. Methodology. All gastric biopsy specimens were obtained during upper gastrointestinal endoscopy from patients referred for the exploration of dyspepsia. The urease positive samples by rapid urease test were cultured according to standard microbiological procedures and H. pylori were grown under microaerophilic conditions on selective Pylori agar. H. pylori antibiotic sensitivity was examined using E-test. In addition, the mutations of the corresponding gene were studied by GenoType HelicoDR DNA strip testing. Results. Three hundred twenty patients, 216 female and 104 male in the ages range of 18 to 83 years were included in this study. Rapid urease test yielded positive results for 65.9% (211/320). Among them, we have successfully obtained 72% H. pylori isolates. The antibiotic resistance rates were 35.5% for clarithromycin, 68.4% metronidazole, 23.0% amoxicillin, 25.0% tetracycline, 28.2% erythromycin and 14.5% nitrofuranton. Resistance for 2 drugs was 34.5% and that of 3 drugs was observed in 14.5% of isolates. The most prevalent mutation was A2147G followed by A2146G and D91Y. The prevalence of H. pylori infection increased among Mongolian population and the prevalence of resistance of H. pylori is very high to metronidazole, and moderate to clarithromycin. Conclusion. The data on antimicrobial susceptibilities provided by the present study is may assist the clinicians on the effectiveness of treatment regimens.

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The Evolution of Helicobacter pylori Antibiotics Resistance Over 10 Years in Beijing, China

Cited by 132 publications

References 31 publications

Trends in Secondary Antibiotic Resistance of Helicobacter pylori from 2007 to 2014: Has the Tide Turned?

Trends in Secondary Antibiotic Resistance of Helicobacter pylori from 2007 to 2014: Has the Tide Turned?

Susceptibilidad antibiótica de Helicobacter pylori: un estudio de prevalencia en pacientes con dispepsia en Quito-Ecuador

Antibiotic resistance of Helicobacter pylori in Mongolia

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