The evolution of magnetic resonance enterography in the assessment of motility disorders in children

Menys, Alex; Saliakellis, Efstratios; Borrelli, Osvaldo; Thapar, Nikhil; Taylor, Stuart A.; Watson, Tom

doi:10.1016/j.ejrad.2018.08.017

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…Some manual 21 and semiautomated 22 MRI methods give meaningful bowel motility metrics, but these can be labour‐intensive and can require bowel preparation. Several recent reviews 17,23,24 have made a case for the development of quantitative and noninvasive measures of bowel function. However, MRI measures of bowel motility and transit are challenging, being subject to many of the same limitations as cardiac MRI methods, 25 and there are obstacles to the widespread adoption of these techniques.…”

Section: Introductionmentioning

confidence: 99%

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A novel method for measuring bowel motility and velocity with dynamic magnetic resonance imaging in two and three dimensions

et al. 2021

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Increasingly, dynamic magnetic resonance imaging (MRI) has potential as a noninvasive and accessible tool for diagnosing and monitoring gastrointestinal motility in healthy and diseased bowel. However, current MRI methods of measuring bowel motility have limitations: requiring bowel preparation or long acquisition times; providing mainly surrogate measures of motion; and estimating bowel‐wall movement in just two dimensions. In this proof‐of‐concept study we apply a method that provides a quantitative measure of motion within the bowel, in both two and three dimensions, using existing, vendor‐implemented MRI pulse sequences with minimal bowel preparation. This method uses a minimised cost function to fit linear vectors in the spatial and temporal domains. It is sensitised to the spatial scale of the bowel and aims to address issues relating to the low signal‐to‐noise in high‐temporal resolution dynamic MRI scans, previously compensated for by performing thick‐slice (10‐mm) two‐dimensional (2D) coronal scans. We applied both 2D and three‐dimensional (3D) scanning protocols in two healthy volunteers. For 2D scanning, analysis yielded bi‐modal velocity peaks, with a mean antegrade motion of 5.5 mm/s and an additional peak at ~9 mm/s corresponding to longitudinal peristalsis, as supported by intraoperative data from the literature. Furthermore, 3D scans indicated a mean forward motion of 4.7 mm/s, and degrees of antegrade and retrograde motion were also established. These measures show promise for the noninvasive assessment of bowel motility, and have the potential to be tuned to particular regions of interest and behaviours within the bowel.

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Section: Introductionmentioning

confidence: 99%

“…Some manual 21 and semiautomated 22 MRI methods give meaningful bowel motility metrics, but these can be labour-intensive and can require bowel preparation. Several recent reviews 17,23,24 have made a case for the development of quantitative and noninvasive measures of bowel function.…”

Section: Introductionmentioning

confidence: 99%

A novel method for measuring bowel motility and velocity with dynamic magnetic resonance imaging in two and three dimensions

et al. 2021

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Simultaneous assessment of colon motility in children with functional constipation by cine-MRI and colonic manometry: a feasibility study

et al. 2021

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Background Colonic manometry is the current reference standard for assessing colonic neuromuscular function in children with intractable functional constipation (FC). Recently, cine magnetic resonance imaging (cine-MRI) has been proposed as a non-invasive alternative. We compared colonic motility patterns on cine-MRI with those obtained by manometry in children, by stimulating high-amplitude propagating contractions (HAPCs) with bisacodyl under manometric control while simultaneously acquiring cine-MRI. Methods After Institutional Review Board approval, adolescents with FC scheduled to undergo colonic manometry were included. A water-perfused 8-lumen catheter was used for colonic manometry recordings. After an intraluminal bisacodyl infusion, cine-MRI sequences of the descending colon were acquired for about 30 min simultaneously with colonic manometry. Manometry recordings were analysed for HAPCs. MRI images were processed with spatiotemporal motility MRI techniques. The anonymised motility results of both techniques were visually compared for the identification of HAPCs in the descending colon. Results Data regarding six patients (three males) were analysed (median age 14 years, range 12–17). After bisacodyl infusion, three patients showed a total of eleven HAPCs with colonic manometry. Corresponding cine-MRI recorded high colonic activity during two of these HAPCs, minimal activity during seven HAPCs, while two HAPCs were not recorded. In two of three patients with absent HAPCs on manometry, colonic activity was recorded with cine-MRI. Conclusions Simultaneous acquisition of colonic cine-MRI and manometry in children with FC is feasible. Their motility results did not completely overlap in the identification of HAPCs. Research is needed to unravel the role of cine-MRI in this setting.

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Functional constipation in children: What physicians should know

Tran¹,

Sintusek²

2023

World J Gastroenterol

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The evolution of magnetic resonance enterography in the assessment of motility disorders in children

Cited by 3 publications

References 67 publications

A novel method for measuring bowel motility and velocity with dynamic magnetic resonance imaging in two and three dimensions

A novel method for measuring bowel motility and velocity with dynamic magnetic resonance imaging in two and three dimensions

Simultaneous assessment of colon motility in children with functional constipation by cine-MRI and colonic manometry: a feasibility study

Functional constipation in children: What physicians should know

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