The evolution of MHC diversity in house mice

Penn, Dustin J.; Musolf, Kerstin

doi:10.1017/cbo9781139044547.011

Cited by 5 publications

(4 citation statements)

References 185 publications

(253 reference statements)

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“…Female and male house mice have been reported to use odor cues to differentiate between +/ t and +/+ in Y‐maze choice tests (Egid and Lenington ; Lenington and Egid ). There is evidence for MHC‐dependent mate choice in several species including house mice (Roberts ; Penn and Musolf ), but not every study finds such evidence (Milinski ; Penn and Musolf ). Where effects are found, they are typically weak (Milinski ).…”

Section: Discussionmentioning

confidence: 99%

Mate choice for genetic compatibility in the house mouse

Lindholm

Musolf

Weidt

et al. 2013

Ecology and Evolution

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103

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In house mice, genetic compatibility is influenced by the t haplotype, a driving selfish genetic element with a recessive lethal allele, imposing fundamental costs on mate choice decisions. Here, we evaluate the cost of genetic incompatibility and its implication for mate choice in a wild house mice population. In laboratory reared mice, we detected no fertility (number of embryos) or fecundity (ability to conceive) costs of the t, and yet we found a high cost of genetic incompatibility: heterozygote crosses produced 40% smaller birth litter sizes because of prenatal mortality. Surprisingly, transmission of t in crosses using +/t males was influenced by female genotype, consistent with postcopulatory female choice for + sperm in +/t females. Analysis of paternity patterns in a wild population of house mice showed that +/t females were more likely than +/+ females to have offspring sired by +/+ males, and unlike +/+ females, paternity of their offspring was not influenced by +/t male frequency, further supporting mate choice for genetic compatibility. As the major histocompatibility complex (MHC) is physically linked to the t, we investigated whether females could potentially use variation at the MHC to identify male genotype at the sperm or individual level. A unique MHC haplotype is linked to the t haplotype. This MHC haplotype could allow the recognition of t and enable pre- and postcopulatory mate choice for genetic compatibility. Alternatively, the MHC itself could be the target of mate choice for genetic compatibility. We predict that mate choice for genetic compatibility will be difficult to find in many systems, as only weak fertilization biases were found despite an exceptionally high cost of genetic incompatibility.

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Section: Discussionmentioning

confidence: 99%

Mate choice for genetic compatibility in the house mouse

Lindholm

Musolf

Weidt

et al. 2013

Ecology and Evolution

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103

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“…Several studies have analysed the influence of MHC on partner choice for house mice. They mostly support the hypothesis of disassortative mating [23, 24] and raised evidence for familial imprinting [23, 25]. Familial imprinting is the non-genetical transmission (i.e.…”

Section: Introductionmentioning

confidence: 70%

No speed dating please! Patterns of social preference in male and female house mice

Linnenbrink

Merten

2017

Front Zool

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BackgroundIn many animal species, interactions between individuals of different sex often occur in the context of courtship and mating. During these interactions, a specific mating partner can be chosen. By discriminating potential mates according to specific characteristics, individuals can increase their evolutionary fitness in terms of reproduction and offspring survival. In this study, we monitored the partner preference behaviour of female and male wild house mice (Mus musculus domesticus) from populations in Germany (G) and France (F) in a controlled cage setup for 5 days and six nights. We analysed the effects of individual factors (e.g. population origin and sex) on the strength of preference (selectivity), as well as dyadic factors (e.g. neutral genetic distance and major histocompatibility complex (MHC) dissimilarity) that direct partner preferences.ResultsSelectivity was stronger in mice with a pure population background than mixed individuals. Furthermore, female mice with a father from the German population had stronger selectivity than other mice. In this group, we found a preference for partners with a larger dissimilarity of their father’s and their partner’s MHC, as assessed by sequencing the H2-Eß locus. In all mice, selectivity followed a clear temporal pattern: it was low in the beginning and reached its maximum only after a whole day in the experiment. After two days, mice seemed to have chosen their preferred partner, as this choice was stable for the remaining four days in the experiment.ConclusionsOur study supports earlier findings that mate choice behaviour in wild mice can be paternally influenced. In our study, preference seems to be potentially associated with paternal MHC distance. To explain this, we propose familial imprinting as the most probable process for information transfer from father to offspring during the offspring’s early phase of life, which possibly influences its future partner preferences. Furthermore, our experiments show that preferences can change after the first day of encounter, which implies that extended observation times might be required to obtain results that allow a valid ecological interpretation.Electronic supplementary materialThe online version of this article (doi:10.1186/s12983-017-0224-y) contains supplementary material, which is available to authorized users.

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“…Proteins encoded by MHC genes bind peptides derived from pathogens and present them on the cell surface for recognition by T cells. MHC genes were first discovered in classical inbred strains of house mice (reviewed in Klein, 1981 , 1986 ; Penn and Musolf, 2012 ). Wild house mice have also played a major role in advancing our understanding of the MHC.…”

Section: Insights From Wild House Micementioning

confidence: 99%

“…One area of particular interest is mate choice. Data suggest that individual mice prefer mates with dissimilar MHC haplotypes, a form of disassortative mating (e.g., Penn and Potts, 1998 ; reviewed in Penn and Musolf, 2012 ). Such mating preferences could function to improve offspring resistance to pathogens, reduce inbreeding, or both.…”

Section: Insights From Wild House Micementioning

confidence: 99%

Insights into mammalian biology from the wild house mouse Mus musculus

Phifer‐Rixey

Nachman

2015

eLife

169

127

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The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.DOI: http://dx.doi.org/10.7554/eLife.05959.001

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The evolution of MHC diversity in house mice

Cited by 5 publications

References 185 publications

Mate choice for genetic compatibility in the house mouse

Mate choice for genetic compatibility in the house mouse

No speed dating please! Patterns of social preference in male and female house mice

Insights into mammalian biology from the wild house mouse Mus musculus

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