The evolution of mitral valve prolapse: insights from the Framingham Heart Study

Abstract

The Framingham Heart Study group has described the non-diagnostic variants may evolve into mitral valve prolapse over time. These non-diagnostic variants include minimal systolic displacement, and abnormal anterior coaptation which is measured on surface echocardiography. Computed tomography and cardiac magnetic resonance imaging are evolving and can assess the degree of mitral regurgitation (MR); imaging techniques aside, genetic and proteomic detection of mitral prolapse is also evolving. However, the genetic basis for mitral prolapse is complex and likely involves multiple genetic loci. The same is also true for work determining possible biomarkers associated with mitral prolapse. The present study may be useful in counseling patients with a family history of mitral prolapse. Registry data is therefore of paramount importance in providing unbiased insight into this common disease.

Propensity-matched analysis of outcomes after mitral valve surgery between trainees and consultants (institutional report)

“…Mitral valve (MV) surgery is the recommended intervention in patients who have severe mitral regurgitation (MR) or mitral stenosis with signs and/or symptoms despite optimal therapy [1][2][3]. The Framingham study showed an estimated 2-3% prevalence of MV prolapse, a proportion of which will progress to severe MR requiring surgical intervention [4]. Keeping in mind this high burden of disease, it is imperative that the future cardiac surgeons are adequately trained in MV surgery.…”

The mitral insufficiency in connective tissue dysplasia. What should a doctor know today? A review

“…МН изучают давно, и достаточно длительный промежуток времени шли дискуссии по поводу этиологии, особенностей клинического течения, диагностики, лечебной тактики в отношении данного заболевания [1,6,16]. По результатам Фремингемского исследования, МН является самой частой клапанной патологией: умеренная и тяжелая степень в общей популяции встречаются в 1,7% случаев и составляют 60% изолированной хирургии МК [15,19], заболеваемость увеличивается с возрастом -у пациентов старше 75 лет аналогичная степень недостаточности имеет место в 9,3% случаев. Различий по частоте встречаемости в зависимости от пола и этнической принадлежности не обнаружено [23].…”

Mitral Regurgitation in Patients Undergoing Noncardiac Surgery

“…[9][10][11] In degenerative MV disease, MV prolapse (MVP), which is defined as leaflet protrusion by more than 2 mm above the mitral annular plane, is most often caused by myxomatous degeneration of the MV. 12 Most cases of myxomatous MVP are sporadic, though familial cases have been reported, and MVP is known to occur in association with connective tissue disorders like Marfan and Ehlers-Danlos syndrome. 13 Myxomatous valves demonstrate thickened and redundant leaflets, annular dilation, and elongation of the chordae tendineae, which may rupture over time.…”