The evolution of MRI probes: from the initial development to state‐of‐the‐art applications

Mulder, Willem J. M.; McMahon, Michael T.; Nicolay, Klaas

doi:10.1002/nbm.2976

Cited by 7 publications

(7 citation statements)

References 49 publications

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“…MRI is based on the spin-lattice relaxation (T 1 contrast) or the spin-spin relaxation (T 2 contrast) times of protons contained in different microstructures of the organs to create imaging contrast. As a powerful imaging modality in clinical medicine, MRI is a promising candidate for monitoring the biodistribution and site-specific accumulation of DDSs because it can produce non-invasive, tissue-depth-independent images with high spatial and temporal resolutions [112][113][114]. To improve its imaging sensitivity and resolution, paramagnetic ions, such as gadolinium (Gd III ) [115,116], manganese (Mn II ) [117], and iron (Fe III ) [118], are typically used as MRI contrast agents to provide magnetic functionality.…”

Section: Mri For Drug Release Monitoringmentioning

confidence: 99%

Recent advances in drug release monitoring

et al. 2019

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Monitoring drug release in vitro and in vivo is of paramount importance to accurately locate diseased tissues, avoid inappropriate drug dosage, and improve therapeutic efficiency. In this regard, it is promising to develop strategies for real-time monitoring of drug release inside targeted cells or even in living bodies. Thus far, many multi-functional drug delivery systems constructed by a variety of building blocks, such as organic molecules, polymeric nanoparticles, micelles, and inorganic nanoparticles, have been developed for drug release monitoring. Especially, with the advancements in imaging modalities relating to nanomaterials, there has been an increasing focus on the use of non-invasive imaging techniques for monitoring drug release and drug efficacy in recent years. In this review, we introduce the application of fluorescence imaging, magnetic resonance imaging (MRI), surface-enhanced Raman scattering (SERS), and multi-mode imaging in monitoring drug release, involving a variety of nanomaterials such as organic or inorganic nanoparticles as imaging agents; their design principles are also elaborated. Among these, a special emphasis is placed on fluorescence-based drug release monitoring strategies, followed by a brief overview of MRI, SERS, and multi-mode imaging-based strategies. In the end, the challenges and prospects of drug release monitoring are also discussed.

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Section: Mri For Drug Release Monitoringmentioning

confidence: 99%

Recent advances in drug release monitoring

et al. 2019

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“…Gd 3 + complexes combinedw ith therapeutic approaches have been widely investigated in this context,b oth in the class of nanoparticles and molecular probes. [8][9] For all applications, particular attention should be paid to ensure high thermodynamic stability and kinetic inertness of the chelates.T his aspecti se specially important for the systemst hat change coordination environment (change in the hydration number)u pon external stimuli.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, small‐molecule theranostic agents hold promise for easier characterization and better control of the physical‐chemical properties. Gd 3+ complexes combined with therapeutic approaches have been widely investigated in this context, both in the class of nanoparticles and molecular probes . For all applications, particular attention should be paid to ensure high thermodynamic stability and kinetic inertness of the chelates.…”

Section: Introductionmentioning

confidence: 99%

Lanthanide Complexes in Molecular Magnetic Resonance Imaging and Theranostics

Lacerda

Tóth

2017

ChemMedChem

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Lanthanide complexes have attracted much attention in the biomedical field, and today various imaging applications make use of their versatile magnetic and luminescence properties. In this minireview, we give insight into the mechanistic aspects that allow modulation of the relaxation or chemical exchange saturation transfer (CEST) features, and thus the magnetic resonance imaging (MRI) efficiency of paramagnetic lanthanide chelates in order to create agents that are capable of providing an MRI response as a function of a specific biomarker. We focus on the detection of neurotransmitters, enzymatic activities, and amyloid peptides. We also describe two selected theranostic strategies: 1) a novel approach directed at monitoring drug release from liponanoparticles and 2) molecular or nanoparticle probes for the MRI visualization of photosensitizer delivery in photodynamic therapy.

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Section: Introductionmentioning

confidence: 99%

“…11 Typically, to generate HDL biomimetic nanoparticles, apolipoprotein APOA1 is incubated with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1-myristoyl-2-hydroxy-sn-glycero-3phosphocholine (MHPC), 12 although the use of alternative lipids and peptides has also been reported for HDL-like nanoparticles. 13 The introduction of paramagnetic magnetic resonance imaging (MRI) probes (e.g., gadolinium ions) in molecules of biomedical interest is an extended practice in the field of molecular imaging, allowing the tracking of the in vivo fate of the molecules by noninvasive means. 9,14 Paramagnetic compounds influence the physicochemical environment of nearby water molecules, shortening the magnetic resonance longitudinal (T1) or transversal (T2) relaxation times (i.e., increasing the relaxation rates, defined as R1 = 1/T1 and R2 = 1/T2).…”

Section: ■ Introductionmentioning

confidence: 99%

Conformational Changes in High-Density Lipoprotein Nanoparticles Induced by High Payloads of Paramagnetic Lipids

et al. 2016

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High-density lipoprotein (HDL) nanoparticles doped with gadolinium lipids can be used as magnetic resonance imaging diagnostic agents for atherosclerosis. In this study, HDL nanoparticles with different molar fractions of gadolinium lipids (0 < xGd-lipids < 0.33) were prepared, and the MR relaxivity values (r1 and r2) for all compositions were measured. Both r1 and r2 parameters reached a maximal value at a molar fraction of approximately xGd-lipids = 0.2. Higher payloads of gadolinium did not significantly increase relaxivity values but induced changes in the structure of HDL, increasing the size of the particles from dH = 8.2 ± 1.6 to 51.7 ± 7.3 nm. High payloads of gadolinium lipids trigger conformational changes in HDL, with potential effects on the in vivo behavior of the nanoparticles.

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The evolution of MRI probes: from the initial development to state‐of‐the‐art applications

Abstract: Watch a video introduction to this special issue.

Cited by 7 publications

References 49 publications

Recent advances in drug release monitoring

Recent advances in drug release monitoring

Lanthanide Complexes in Molecular Magnetic Resonance Imaging and Theranostics

Conformational Changes in High-Density Lipoprotein Nanoparticles Induced by High Payloads of Paramagnetic Lipids

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